Yeşilırmak, Filiz

Profile URL
https://hdl.handle.net/11147/16205
Name Variants
Yesilirmak, F
Yeşilırmak, F.
Yeşilırmak, F
Yeşilirmak, Filiz
Yesilirmak, Filiz
Yesilirmak, F.
Job Title
Email Address
Main Affiliation
04.01. Department of Chemistry
Status
Former Staff
Website
ORCID ID
Scopus Author ID
34067911800
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID

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Documents

4

Citations

42

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1

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Scholarly Output

1

Articles

1

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725/446

Supervised MSc Theses

0

Supervised PhD Theses

0

WoS Citation Count

1

Scopus Citation Count

1

Patents

0

Projects

0

WoS Citations per Publication

1.00

Scopus Citations per Publication

1.00

Open Access Source

1

Supervised Theses

0

JournalCount
Turkish Journal of Biology1
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  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Comparative Proteomic Analysis of Bacillus Thuringiensis Wild-Type and Two Mutant Strains Disturbed in Polyphosphate Homeostasis
    (TUBITAK, 2018) Yeşilırmak, Filiz; Doruk, Tuğrul; Yılmaz, Şerif; Tunca Gedik, Sedef
    Polyphosphate polymer (polyP) plays a very important role in every living cell. Synthesis of this linear polymer of phosphate (Pi) residues is catalyzed by the polyphosphate kinase (PPK) enzyme. It was shown that high levels of intracellular polyphosphate stimulated endotoxin production by Bacillus thuringiensis subsp. israelensis (Bti). In this study, proteomic analysis of the wild-type and two mutant strains, overexpressing the ppk gene (Bti pHTppk) and without the ppk gene (Bti ∆ppk), were used to clarify the relation between polyP and endotoxin production. Intracellular proteins were separated by two-dimensional gel electrophoresis; 41 spots of interest (proteins differentially expressed) were obtained and 35 of them were identified by mass spectrometry. Analysis of the protein profiles showed that there is a general decrease in the expression levels of proteins related with energy metabolism, amino acid metabolism, and purine biosynthesis in both Bti pHTppk and Bti ∆ppk. Gluconeogenesis and fatty acid metabolism were also slowed down in both strains, whereas expression of stress response proteins increased compared to the wild-type. These results suggested that changes in polyP concentration cause a general stress condition inside the cell, which in turn stimulates secondary metabolite synthesis