Karayanık, Gizem

Profile URL
https://hdl.handle.net/11147/15949
Name Variants
Job Title
Email Address
Main Affiliation
01. Izmir Institute of Technology
Status
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
Research Products
GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
1
Research Products
QUALITY EDUCATION4
QUALITY EDUCATION
0
Research Products
GENDER EQUALITY5
GENDER EQUALITY
0
Research Products
CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
0
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
Research Products
SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
CLIMATE ACTION13
CLIMATE ACTION
0
Research Products
LIFE BELOW WATER14
LIFE BELOW WATER
0
Research Products
LIFE ON LAND15
LIFE ON LAND
0
Research Products
PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
Research Products
This researcher does not have a Scopus ID.
This researcher does not have a WoS ID.
No records found in other affiliations.
Scholarly Output

1

Articles

0

Views / Downloads

1639/818

Supervised MSc Theses

1

Supervised PhD Theses

0

WoS Citation Count

0

Scopus Citation Count

0

Patents

0

Projects

0

WoS Citations per Publication

0.00

Scopus Citations per Publication

0.00

Open Access Source

1

Supervised Theses

1

Journals data is not available

Scopus Quartile Distribution

Quartile distribution chart data is not available

Competency Cloud

GCRIS Competency Cloud

Filters

20211

Settings

Author of Publication: search.filters.isAuthorOfPublication.2dbaeb2b-bb54-479a-9f14-13683588e42b

Scholarly Output Search Results

Now showing 1 - 1 of 1
  • Master Thesis
    Discovery of Biological Pathways That Have a Role in the Etiopathogenesis of Macular Degeneration by Genetic Investigations
    (01. Izmir Institute of Technology, 2021) Karayanık, Gizem; Sezgin, Efe; Karayanık, Gizem; Sezgin, Efe; 01. Izmir Institute of Technology; 03.08. Department of Food Engineering; 03. Faculty of Engineering
    Macular Degeneration is a common, progressive, multifactorial, and complex eye disorder among people over 50 years old. The etiology of Macular Degeneration is still not known. The main hypothesis of this thesis is that chronic inflammation and oxidative stress are the major factors for the development of AMD. Therefore, we focused on firstly an overview of the current Literatureto understand risk factors of AMD development, transcriptomic of Retina, and molecules that changing with aging. The genetic, and nongenetic factors associated with AMD are reviewed. Age, smokinghistory, gender, race, cardiovascular disease, hypertension, diabetes, hyperlipidemia, kidney disease, and HIV infection status were chosen as non-genetic factors. Genetic factors included ARMS2, C2, C3, CFH, CFI, CX3CR1, IL10RA, IL28B, LIPC, and SYN3. Secondly, the influence of these factors on early AMD development was investigated by focusing on patients with chronic HIV infection. Based on the idea that patients with acquired immunodeficiency syndrome (AIDS) can be a good model for Aging. Older age was observed to be the primary risk factor for AMD development. Smoking, cardiovascular disease, hypertension, diabetes and injection drug use, CFH (RS800292), IL10RA (RS3135932) and IL10RA (RS2229113) were also observed to be significantly associated with AMD development. According to pathway enrichment analyses, complement activation pathways, lipid metabolism pathways, cholesterol transport, receptor-mediated endocytosis, and extracellular matrix organization mechanism can be involved in AMD development. Multivariable modelsaccounting for other variables identified IL10RA (RS3135932) and injection drug as risk factors for AMD. For the first time, a significant association betweenIL10RA(RS3135932)and AMD is observed. As a conclusion, chronic inflammation and oxidative stress can be mainly risk factor for AMD development.