Vural, Ezgi

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https://hdl.handle.net/11147/16037
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Main Affiliation
01. Izmir Institute of Technology
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Scholarly Output

2

Articles

1

Views / Downloads

1073/354

Supervised MSc Theses

1

Supervised PhD Theses

0

WoS Citation Count

4

Scopus Citation Count

4

Patents

0

Projects

0

WoS Citations per Publication

2.00

Scopus Citations per Publication

2.00

Open Access Source

1

Supervised Theses

1

JournalCount
Journal of Materials Chemistry B1
Current Page: 1 / 1

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Author of Publication: search.filters.isAuthorOfPublication.33faaa20-5395-4b1e-b56c-ae2eef4ff1e8

Scholarly Output Search Results

Now showing 1 - 2 of 2
  • Master Thesis
    Studies Toward the Asymmetric Synthesis of Novel Chiral 1,4-Oxazepan Derivatives
    (01. Izmir Institute of Technology, 2020) Vural, Ezgi; Çağır, Ali; Çağır, Ali; 01. Izmir Institute of Technology; 04.01. Department of Chemistry; 04. Faculty of Science
    Pharmacophore design to inhibit the interaction between p53 and MDM2 became a novel approach for cancer therapy. p53, known as the guardian of genome, controls the cell cycle arrest, apoptosis and DNA repair under stress. Nonetheless, when over-expressed, MDM2 causes proliferation in the cell and eventually tumorgenesis. The feedback mechanism between p53 and MDM2 arises from the interaction of p53 through the hydrophobic cleft which consists of Phe19, Trp23 and Leu26 aminoacids in the N-terminal of MDM2. In this study, it was aimed to synthesize a new, chiral 1,4-oxazepan-5-one derivatives by asymmetric synthesis. (R)-2-amino-2-(4-chlorophenyl)acetic acid was used as starting material. Amino group was protected by trityl group then the carboxylic acid part was reduced by LiAlH4 to produce N-trityl-protected amino alcohol. Dess Martin periodinane was used for the oxidation of the alcohol to the aldehyde, then 3-chlorophenylmagnesium bromide was added to the aldehyde by Grignard reaction. Deprotection of N-trityl was performed with TFA then, coupling reactions of produced aminoalcohol with different α,β-unsaturated carboxylic acids were performed by HATU and DIPEA. Despite all of the attempts, cyclization to seven membered 1,4-oxazepan-5-one ring was never achieved.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 4
    Tailored Bodipy-Based Fluorogenic Probes for Phosgene Detection: a Comparative Evaluation of Recognition Sites
    (Royal Soc Chemistry, 2024) Dartar, Suay; Emrullahoğlu, Mustafa; Kaya, Beraat Umur; Kaya, Beraat Umur; Yayak, Yanki Oncu; Vural, Ezgi; Vural, Ezgi; Dartar, Suay; Emrullahoglu, Mustafa; 01. Izmir Institute of Technology; 04.01. Department of Chemistry; 04.04. Department of Photonics; 04. Faculty of Science
    We constructed two novel boron-dipyrromethene (BODIPY)-based fluorescent probes, BOPD and BOBA, each equipped with the phosgene specific recognition units o-phenylenediamine (OPD) and o-aminobenzylamine (OBA) at the 2-position of the BODIPY core. BOPD and BOBA represent rare examples of BODIPY-based probes that operate by modulating an intramolecular charge transfer process (ICT), as validated by computational studies. We systematically compared the analytic performance of those recognition units while focusing on selectivity, fluorescence turn-on ratios and response times. Probe BOBA, equipped with OBA as the recognition unit, demonstrated a remarkably low detection limit (i.e., 1.40 nM) and a rapid response time (<10 s) for triphosgene. By comparison, BOPD, featuring an OPD unit, showed superior selectivity towards triphosgene, with a detection limit of 93 nM and a response time of up to 30 s. A portable sensing platform was developed by loading BOPD onto test strips made of TLC plates, nonwoven materials and small-headed cotton swabs, which were assessed for their effectiveness in detecting phosgene. We additionally performed the first successful application of a fluorescent probe, namely BOPD, for monitoring the accumulation of phosgene in plants.