Sezgin, Efe

Profile URL
https://hdl.handle.net/11147/15854
Name Variants
Sezgin, E
Sezgin, E.
Job Title
Email Address
efesezgin@iyte.edu.tr
Main Affiliation
03.08. Department of Food Engineering
Status
Current Staff
Website
https://food.iyte.edu.tr/wp-content/uploads/sites/89/2019/04/Efe_Sezgin_CV_2016.pdf
ORCID ID
0000-0002-8000-7485
Scopus Author ID
7003392648
Turkish CoHE Profile ID
Google Scholar ID
L_OzpkMAAAAJ
WoS Researcher ID
B-8418-2012

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
9
Research Products
GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
44
Research Products
QUALITY EDUCATION4
QUALITY EDUCATION
7
Research Products
GENDER EQUALITY5
GENDER EQUALITY
0
Research Products
CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
6
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
6
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
4
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
9
Research Products
REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
Research Products
SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
1
Research Products
RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
5
Research Products
CLIMATE ACTION13
CLIMATE ACTION
7
Research Products
LIFE BELOW WATER14
LIFE BELOW WATER
4
Research Products
LIFE ON LAND15
LIFE ON LAND
2
Research Products
PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
Research Products
Documents

69

Citations

1976

h-index

23

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Documents

92

Citations

1857

Go to WoS profile
Scholarly Output

82

Articles

41

Views / Downloads

59211/19046

Supervised MSc Theses

21

Supervised PhD Theses

2

WoS Citation Count

838

Scopus Citation Count

910

Patents

0

Projects

6

WoS Citations per Publication

10.22

Scopus Citations per Publication

11.10

Open Access Source

54

Supervised Theses

23

JournalCount
Annals of Surgical Oncology12
Lymphatic Research and Biology4
Frontiers in Genetics3
Ophthalmology Science2
Heredity2
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Scholarly Output Search Results

Now showing 1 - 10 of 82
  • Article
    Citation - WoS: 1
    Aso Visual Abstract: Intervention for Hepatic and Pulmonary Metastases in Breast Cancer Patients-Prospective, Multi-Institutional Registry Study: Imet; Protocol Mf 14-02
    (Springer, 2022) Soran, Atilla; Özbaş, Serdar; Özçınar, Beyza; Işık, Arda; Doğan, L.; Şenol, Kazım; Dağ, Ahmet; Karanlık, Hasan; Aytaç, Özgür; Karadeniz Çakmak, Güldeniz; Dalcı, Kubilay; Doğan, Mutlu; Sezer, Atakan Y.; Gökgöz, Şehsuvar; Özyar, Enis; Sezgin, Efe
    The aim of our prospective, multicenter registry study was to investigate the importance of interventions for operable lung and/or liver metastasis for breast cancer (BC) survival (https://doi.org/10.1245/s10434-022-12239-z). The results reveal that surgical resection or ablative interventions may contribute to survival in patients with BC with limited number and operable metachronous hepatic/pulmonary metastases. Ultimately, randomized studies will determine whether intervention on lung and liver metastatic sites should be performed. In the meantime, such interventions can be considered on select patients.
  • Article
    Citation - WoS: 16
    Citation - Scopus: 16
    Secular Trends in Opportunistic Infections, Cancers and Mortality in Patients With Aids During the Era of Modern Combination Antiretroviral Therapy
    (John Wiley and Sons Inc., 2018) Sezgin, Efe; Van Natta, Mark L.; Thorne, Jennifer E.; Puhan, M. A.; Jabs, D. A.
    Objectives: The aim of the study was to estimate the incidence of, determine risk factors for, and investigate the consequences of opportunistic infections (OIs) and malignancies among patients with the acquired immune deficiency syndrome (AIDS) in the era of modern combination antiretroviral therapy (cART). Methods: Three enrolment periods (1998–2002, 2003–2005 and 2006–2012), corresponding to changes in predominant cART regimens, were compared among 1889 participants enrolled in a prospective cohort study, the Longitudinal Study of Ocular Complications of AIDS (LSOCA). Incidences of AIDS-related OIs and cancers were estimated. Multivariate logistic and Cox regression models were used to determine the effect of demographic and clinical characteristics on OIs and mortality. Results: Between participants enrolled in the 1998–2002 and 2006–2012 enrolment periods, the incidence of OIs decreased from 27 per 1000 person-years (PY) to 11 per 1000 PY (P < 0.001), and mortality decreased from 41 per 1000 PY to 18 per 1000 PY (P < 0.0001), corresponding to improvements in cART regimens. Conclusions: Improvements in cART regimens led to a progressive decline in the incidence of OIs and mortality between 1999 and 2013 among patients with AIDS in the era of modern cART.
  • Conference Object
    The Importance of Loco-Regional Tumor Burden and Surgery on Survival in Patients With De Novo Stage Iv Breast Cancer; Post-Hoc Analyses of Protocol Mf07-01
    (American Association for Cancer Research, 2017) Özmen, Vahit; Özbaş, Serdar; Karanlık, Hasan; Müslümanoğlu, Mahmut; İğci, Abdullah; Cantürk, Z.; Sezgin, Efe
    Background: The MF07-01 trial is a multicenter phase III randomized controlled trial of treatment naive stage IV BC patients comparing loco-regional surgery (LRS) followed by appropriate systemic therapy (ST) versus ST alone. Aims: To evaluate the importance of loco-regional tumor burden and surgery on overall survival rate in patients with de novo stage IV breast cancer.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Diverse Selection Pressures Shaping the Genetic Architecture of Behçet Disease Susceptibility
    (Frontiers Media S.A., 2022) Sezgin, Efe; Kaplan, Elif
    Behçet disease (BD) is a polygenic, multifactorial, multisystem inflammatory condition with unknown etiology. Global distribution of BD is geographically structured, highest prevalence observed among East Asian, Middle Eastern, and Mediterranean populations. Although adaptive selection on a few BD susceptibility loci is speculated, a thorough evolutionary analysis on the genetic architecture of BD is lacking. We aimed to understand whether increased BD risk in the human populations with high prevalence is due to past selection on BD associated genes. We performed population genetics analyses with East Asian (high BD prevalence), European (low/very low BD prevalence), and African (very low/no BD prevalence) populations. Comparison of ancestral and derived alleles’ frequencies versus their reported susceptible or protective effect on BD showed both derived and ancestral alleles are associated with increased BD risk. Variants showing higher risk to and more significant association with BD had smaller allele frequency differences, and showed less population differentiation compared to variants that showed smaller risk and less significant association with BD. Results suggest BD alleles are not unique to East Asians but are also found in other world populations at appreciable frequencies, and argue against selection favoring these variants only in populations with high BD prevalence. BD associated gene analyses showed similar evolutionary histories driven by neutral processes for many genes or balancing selection for HLA (Human Leukocyte Antigen) genes in all three populations studied. However, nucleotide diversity in several HLA region genes was much higher in East Asians suggesting selection for high nucleotide and haplotype diversity in East Asians. Recent selective sweep for genes involved in antigen recognition, peptide processing, immune and cellular differentiation regulation was observed only in East Asians. We conclude that the evolutionary processes shaping the genetic diversity in BD risk genes are diverse, and elucidating the underlying specific selection mechanisms is complex. Several of the genes examined in this study are risk factors (such as ERAP1, IL23R, HLA-G) for other inflammatory diseases. Thus, our conclusions are not only limited to BD but may have broader implications for other inflammatory diseases.
  • Master Thesis
    Population Genomics of Crohn Disease Susceptibility
    (01. Izmir Institute of Technology, 2024) Narli, Bengisu; Sezgin, Efe; Büyükkileci, Ali Oğuz
    Crohn Hastalığı (CD), gastrointestinal sistemin kronik inflamasyonuna neden olan inflamatuar bir bağırsak hastalığıdır. Modern popülasyonlarda CD'ye yatkınlığı artıran genetik yapının, enfeksiyonlara ve patojenlere direnç gibi belirli çevresel stres faktörlerine karşı seçici avantaj sağlayan türetilmiş bir özellik olduğu iddia edilmektedir. Bu nedenle, CD ile ilişkili genlerde seçilim belirtileri olmalıdır. CD riskinin türetilmiş seçilmiş bir özellik olup olmadığını test etmek için, literatür taramaları yoluyla CD ile ilişkili genler ve varyantlar belirlenmiştir. Allen veriseti ve 1000 Genom Projesi aracılığıyla eski ve modern nüfus verileri toplanmıştır. Veriler Plink ve R kullanılarak analiz edilmiştir. 352 CD risk aleli tanımlanmıştır ve CD ile ilişkili alellerin hastalık risk durumu (koruyucu ve duyarlı) atasal ve türetilmiş durumlarıyla karşılaştırılmıştır. Dünya çapındaki dört metapopülasyonun bu alellere göre farklılaşması incelenmiştir. Ayrıca, eski ve modern popülasyonlar arasındaki alel frekansı farklılıkları karşılaştırılmıştır. Günümüz metapopülasyonları arasındaki genetik farklılaşma ve ayrımın, CD ile ilişkili PUS10 ve PPBP_CXCL5 genlerinin etkisine bağlı olduğu, antik ve modern metapopülasyonlardaki ayrımın ise PPP5C, PPBP_CXCL5 ve AIMP1P2 genlerinin etkisi olduğu gözlemlenmiştir. CD prevalansının daha yüksek olduğu popülasyonlarda daha yüksek risk alel frekanslarına sahip olduğu belirlenmiştir. CD ile ilişkili IRGM, OR2B11 ve IL10 genlerindeki varyantlar, atasal ve modern Avrupa popülasyonları karşılaştırıldığında zaman içinde yüksek alel frekansı değişiklikleri göstermiştir. Gen bazlı son seleksiyon analizleri, CD ile ilişkili HERC2, MACROD2, RBFOX1, ITLN1 ve RNFT1P2 genlerinde etkili olan olası pozitif seçilime işaret etmiştir.
  • Publication
    Geleneksel Fermente Ürünlerimizden İzole Edilen Laktik Asit Bakterileri İle; Angiotensin-ı Enzimi (ace)-inhibitörü Peptidleri ve Gama-aminobütirik Asit (gaba) İçeren; Fonksiyonel Peyniraltı Suyu İçeceği Geliştirilmesi
    (2023) Harsa, Hayriye Şebnem; Polat, Ferhat; Sezgin, Efe; Kaygısız, Meral; Ağırbaşlı, Zeynep; Aluz, Barkın; Esen, Berna
    Proje kapsamında gerçekleştirilen çalışmaların amacı Laktik Asit Bakterileri koleksiyonunun (LAB) antihipertansif yetenek potansiyellerinin değerlendirilmesine ve fermente peynir altı suyu içecek bazlarının geliştirilmesidir. Projenin amacı, antihipertansif özellikleri olan Laktik Asit Bakterileri koleksiyonunun (LAB) ve fermente peynir altı suyu içecek bazlarının geliştirilmesidir. Bu amaçla, 400'den fazla yağsız süt ortamında proteolitik aktiviteleri açısından 400'den fazla LAB incelenmiştir. LAB'lardan 39'u yüksek proteolitik kapasiteye sahiptir. Lactobacillus brevis D9 ve Lactococcus lactis ssp. lactis C24 gibi 34 en yüksek ACE inhibitor aktiviteli bakteriden 13'ü ikili kültürlü fermente peynir altı suyu oluşturmak için seçilmiştir. Fermente sütlerdeki proteolitik aktivite ve ACE inhibitor aktivite of 4.11-1,8 mg/L Lösin ve %49?86 aktivite olarak sırasıyla tespit edilmiştir. İkili kültür fermente peynir altı suyu bazlarında ACE inhibitör aktiviteler %80-97 aralığında bulunmuştur. Seçilen 11 LAB?ın fermentasyon surasındaki proteolitik aktiviteleri HPLC ve SDS-PAGE analizi ile peynir altı suyu proteinlerinin degredasyon profilleri ile değerlendirilmiştir. 300 LAB arasından modifiye sıvı besiyerinde 37 veya 42 oC?de 48 saat inkübasyon sonrası 33 suş GABA üretim kapasitesi gösterdiği ince tabaka kromatografisi (TLC) ile gözlemlenmiştir. Fermente whey içeceği bazı geliştirmek için 10 LAB türü, örneğin Lactiplantibacillus plantarum, Latilactobacillus curvatus and Levilactobacillus brevis, modifiye sıvı besiyerinde 50?367 mg/L konsantrasyonlarında verim göstermesi nedeniyle seçilmiştir. Buna göre, fermente peynir altı suyu bazlarında 24 saat 37 °C sonrası GABA konsantrasyonları 11?21mg/L aralığında hesaplanmıştır. L. brevis D9 suşu ile kakaolu PAS geliştirilmiş ve raf ömrü boyunca pH değişikliği, proteolitik aktivite, ACE inhibitör aktivite ve GABA konsantrasyonları ve mikrobiyal değişim takip edilmiştir. Proje kapsamında incelenen LAB bakterilerinin genomik DNA izolasyonu gerçekleştirilmiş, türe ve gene spesifik 15 farklı primer tasarlanmış, gad operonunda bulunan gadA, gadB, gadC ve gadR genlerinin varlığı PZR ile incelenmiştir. Peynirden izole edilen L. brevis ve L. garvieae suşlarında gad operonu tamamen gösterilmiştir. %1 oranında monosodyum glutamat içeren modifiye MRS ve PAS ortamında 24. ve 48. saat gen anlatımı L. brevis D9 suşunun gadA ve gadB genleri için gösterilmiştir.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    A Pragmatic Grouping Model for Bone-Only De Novo Metastatic Breast Cancer (MetS Protocol MF22-03)
    (MDPI, 2025) Goktepe, Berk; Demirors, Berkay; Senol, Kazim; Ozbas, Serdar; Sezgin, Efe; Lucci, Anthony; Soran, Atilla
    De novo metastatic breast cancer (dnMBC) accounts for 3-10% of newly diagnosed cases, with 20-40% presenting as a bone-only metastatic disease, which can achieve survival outcomes exceeding 10 years with multimodal therapy. However, the role of multimodal therapy remains controversial in the guidelines. Objective: This study aims to identify dnBOMBC subgroups to develop a pragmatic staging system for guiding locoregional therapy decisions. Materials and Methods: Data from the MF07-01 phase III randomized trial (2021, median follow-up time (mFT): 40 months (range 1-131)) and the BOMET prospective multi-institutional registry trial (2021, mFT: 34 months (range 25-45)) were combined for analysis, including only patients who presented with bone-only metastases. Exclusion criteria were patients under 18 and those with a history of prior cancer or cancer metastases. Patients with missing data and positive surgical margins were excluded. Out of 770 patients, 589 were included. Survival analyses were first conducted according to molecular subgroups, after which patients were further stratified by hormone receptor status, human epidermal human epidermal growth factor receptor 2 (HER2) status, tumor grade, and clinical T (cT) stage. Group A (GrA) included hormone receptor (HR)-positive, low- or intermediate-grade tumors at any cT; HR-positive, high-grade tumors with cT0-3; or any HER2-positive tumors. Group B (GrB) included HR-positive, high-grade tumors with cT4 disease or any triple-negative (TN) tumors. Results: The hazard of death (HoD) was 43% lower in GrA than in GrB. Median OS was 65 months (39-104) for GrA patients and 44 months (28-72) for GrB patients (HR 0.57, 95% CI 0.41-0.78, p = 0.0003). Primary tumor surgery (PTS) significantly improved OS in GrA patients, regardless of the number of metastases (solitary: HR, 0.375, 95% CI 0.259-0.543, p < 0.001; multiple: HR 0.435, 95% CI 0.334-0.615, p < 0.001). Conversely, GrB patients did not experience a significant benefit from PTS. Conclusions: This study demonstrates that GrA patients have better OS than GrB patients, and PTS reduces the HoD in GrA patients compared to systemic therapy alone. These findings support using a modified staging system in dnBOBMC to identify patients who may benefit from multimodal therapy including PTS.
  • Article
    Long-Term Outcomes of Türkiye's First Population-Based Mammography Screening Program: a Decade of Breast Cancer Detection and Survival Analysis in Bahçeşehir
    (Bmc, 2025) Ozcinar, Beyza; Aribal, Erkin; Cabioglu, Neslihan; Gurdal, Sibel Ozkan; Varol, Gamze; Akyurt, Nuran; Ozmen, Vahit
    BackgroundThe Bah & ccedil;e & scedil;ehir population-based mammography screening program (BMSP) is an example of T & uuml;rkiye's first population-based screening program. This study aims to reveal the successful implementation of population-based secreening program in one of the low- and middle-income countries, T & uuml;rkiye and long-term results of patients diagnosed with breast cancer during BMSP. MethodsThis study was conducted between 2009 and 2019, in the Bah & ccedil;e & scedil;ehir county of Istanbul. Women between the ages of 40 and 69 living in this region were invited every two years to undergo clinical breast examination (CBE) and mammography screening. All data was recorded in a dedicated software program. Women diagnosed with breast cancer were followed as a separate cohort. ResultsDuring the 10-year screening period, 8,825 women were screened and 146 (1.7%) breast cancers were detected. The median age at diagnosis for these patients was 52.9 years (40-69). The risk of breast cancer was 1.39 times higher (95% CI: 1.01-1.93) in women aged >= 50 compared to those less than 50 years (p = 0.045). The Cox regression analysis revealed that age at first birth, and number of births were significant predictors of breast cancer risk (p < 0.001, and p = 0.011). The breast cancer rate tends to increase as the breast density category progresses from A to D (p < 0.001). The median follow-up time for 146 breast cancer patients was 95.3 months. The 10-year breast cancer specific survival rate was 85%. ConclusionsThis study demonstrates that with a committed team and sufficient infrastructure, screening mammography can be effectively carried out in T & uuml;rkiye, leading to early detection and lower mortality rates. The recommended age to commence screening is 40 years old.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 10
    Factors Associated With the Occurrence and Healing of Umbilical Pilonidal Sinus: a Rare Clinical Entity
    (Lippincott Williams and Wilkins Ltd., 2022) Işık, Arda; Wysocki, Arkadiusz Peter; Memiş, Ufuk; Sezgin, Efe; Yezhikova, Assel; Islambekov, Yersultan
    Objective: Pilonidal sinus disease (PSD) is a chronic inflammatory condition of skin that is thought to be related to implanted loose hair. Although PSD is most frequently seen in the sacrococcygeal region, it can also occur at the axilla, perineum, suprapubic regions, hands, and umbilicus. The aim of this project was to find factors influencing the development and treatment of umbilical PSD. Methods: In this retrospective study, the authors evaluated 82 patients (19 women, 63 men) with a history of umbilical PSD between 2012 and 2020 to determine predisposing factors and treatment modalities. Results: There was a 20% concordance with intergluteal PSD. Smoking was the only modifying factor for recurrence. The three different treatment methods studied (conservative treatment, surgical treatment, silver nitrate) did not differ in recurrence rate (P =.57). Conclusions: Because of its rare nature, umbilical PSD can be misdiagnosed or underdiagnosed. Key aspects of treatment include smoking cessation and a conservative approach.
  • Conference Object
    Citation - WoS: 83
    Citation - Scopus: 87
    Primary Surgery With Systemic Therapy in Patients With De Novo Stage Iv Breast Cancer: 10-Year Follow-Up; Protocol Mf07-01 Randomized Clinical Trial
    (Elsevier, 2021) Soran, Atilla; Özmen, Vahit; Özbaş, Serdar; Karanlık, Hasan; Müslümanoğlu, Mahmut; İğci, Abdullah; Cantürk, Nuh Zafer; Utkan, Zafer; Evrensel, Türkkan; Sezgin, Efe
    Background: The aim of this randomized clinical trial was to evaluate the overall survival (OS) data of patients diagnosed with de novo stage IV breast cancer (BC) who received locoregional treatment (LRT) over a 10-year follow-up. Study Design: The MF07-01 is a 1:1 multicenter, randomized clinical trial comparing the LRT with systemic therapy (ST), where ST was given to all patients either immediately after randomization or after surgical resection of the intact primary tumor. Results: A total of 278 patients were randomized and 265 patients were in the final analysis. At 10-year follow-up, survivals were 19% (95% CI 13%–28%) and 5% (95% CI 2%–12%) in the LRT group and ST group, respectively. Median survival was 46 months for the LRT group and 35 months for the ST group, and hazard of death was 29% lower in the LRT group compared with the ST group (hazard ratio [HR] 0.71; 95% CI 0.59–0.86; p = 0.0003). Conclusions: Patients with a diagnosis of de novo stage IV BC who underwent LRT followed by ST had a 14% higher chance of OS by the end of the 10-year follow-up compared with the patients who received only ST. The longer study follow-up revealed that LRT should be presented to patients when discussing treatment options. © 2021 American College of Surgeons