Didikoğlu, Altuğ
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Didikoglu, Altug
Didikoglu, A.
Didikoglu, A.
Job Title
Email Address
altugdidikoglu@iyte.edu.tr
Main Affiliation
04.06. Department of Neurosciences
Status
Current Staff
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ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
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WoS Researcher ID
Sustainable Development Goals
1NO POVERTY
0
Research Products
2ZERO HUNGER
1
Research Products
3GOOD HEALTH AND WELL-BEING
2
Research Products
4QUALITY EDUCATION
1
Research Products
5GENDER EQUALITY
0
Research Products
6CLEAN WATER AND SANITATION
0
Research Products
7AFFORDABLE AND CLEAN ENERGY
1
Research Products
8DECENT WORK AND ECONOMIC GROWTH
1
Research Products
9INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
10REDUCED INEQUALITIES
0
Research Products
11SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
12RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
13CLIMATE ACTION
0
Research Products
14LIFE BELOW WATER
1
Research Products
15LIFE ON LAND
0
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16PEACE, JUSTICE AND STRONG INSTITUTIONS
1
Research Products
17PARTNERSHIPS FOR THE GOALS
0
Research Products
Documents
22
Citations
283
h-index
9
Documents
22
Citations
269
Scholarly Output
13
Articles
13
Views / Downloads
1287/190
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
86
Scopus Citation Count
87
Patents
0
Projects
0
WoS Citations per Publication
6.62
Scopus Citations per Publication
6.69
Open Access Source
7
Supervised Theses
0
| Journal | Count |
|---|---|
| Journal of Perinatal Medicine | 2 |
| BMC Public Health | 1 |
| Building and Environment | 1 |
| Clocks & Sleep | 1 |
| Communications Medicine | 1 |
Current Page: 1 / 3
Scopus Quartile Distribution
Competency Cloud
13 results
Scholarly Output Search Results
Now showing 1 - 10 of 13
Article Citation - WoS: 5Citation - Scopus: 6Beyond Lux: Methods for Species and Photoreceptor-Specific Quantification of Ambient Light for Mammals(Bmc, 2024) McDowell, Richard J.; Didikoğlu, Altuğ; Didikoglu, Altug; Woelders, Tom; Gatt, Mazie J.; Moffatt, Finn; Notash, Saba; Lucas, Robert J.BackgroundLight is a key environmental regulator of physiology and behaviour. Mistimed or insufficient light disrupts circadian rhythms and is associated with impaired health and well-being across mammals. Appropriate lighting is therefore crucial for indoor housed mammals. Light is commonly measured in lux. However, this employs a spectral weighting function for human luminance and is not suitable for 'non-visual' effects of light or use across species. In humans, a photoreceptor-specific (alpha-opic) metrology system has been proposed as a more appropriate way of measuring light.ResultsHere we establish technology to allow this alpha-opic measurement approach to be readily extended across mammalian species, accounting for differences in photoreceptor types, photopigment spectral sensitivities, and eye anatomy. We develop a high-throughput method to derive spectral sensitivities for recombinantly expressed mammalian opsins and use it to establish the spectral sensitivity of melanopsin from 13 non-human mammals. We further address the need for simple measurement strategies for species-specific alpha-opic measures by developing an accessible online toolbox for calculating these units and validating an open hardware multichannel light sensor for 'point and click' measurement. We finally demonstrate that species-specific alpha-opic measurements are superior to photopic lux as predictors of physiological responses to light in mice and allow ecologically relevant comparisons of photosensitivity between species.ConclusionsOur study presents methods for measuring light in species-specific alpha-opic units that are superior to the existing unit of photopic lux and holds the promise of improvements to the health and welfare of animals, scientific research reproducibility, agricultural productivity, and energy usage.Article Citation - WoS: 1Citation - Scopus: 1Assessment of the Validity and Reliability of Edinburgh Postpartum Depression Scale in Turkish Men(Walter de Gruyter GmbH, 2024) Alkan, C.; Didikoǧlu, A.; Çöme, O.; Yllmaz, B.; Mevsim, V.Objectives: Perinatal depression (PD) affects individuals during pregnancy and early parenthood, resembling major depression. Recent research highlights paternal perinatal depression (PPD) in fathers. PPD has adverse effects on fathers and their children. This study assesses the Turkish version of the Edinburgh Postnatal Depression Scale (EPDS) for Turkish fathers, aiming to provide a tool for PPD identification. Methods: This methodological study validates the EPDS for Turkish fathers and explores associations with demographic and psychosocial factors. The study involved 295 fathers with infants aged 2 weeks to 12 months. The EPDS, originally designed for perinatal depression and validated in Turkish women, was used. Fathers completed a participant information questionnaire, the EPDS, and the Beck Depression Inventory (BDI) during clinic visits. Data on sociodemographic factors, paternal roles, and pregnancy and postpartum support were collected. Mothers also completed the EPDS. Descriptive statistics, exploratory factor analysis, confirmatory factor analysis, and correlation tests were used. Results: The study included fathers with an average age of 30.5 years, mostly with a high school education or higher. The EPDS had a mean total score of 3.1. Factor analysis suggested a three-factor structure for the EPDS in Turkish fathers, including anhedonia, anxiety, and depression. Confirmatory factor analysis validated the three-factor structure, with acceptable model fit indices. Positive correlations were found between fathers' EPDS scores, maternal EPDS scores, and paternal BDI scores. The EPDS effectively discriminated between different levels of depression severity. Various factors, such as education level and lack of support during pregnancy and after childbirth, were associated with higher EPDS scores. Conclusions: These findings emphasize the significance of assessing and addressing PPD in fathers, supporting the use of the EPDS as a valid tool in the Turkish context. The three-factor structure aligns with international research, highlighting the importance of a multi-dimensional approach to PPD assessment. Early intervention can mitigate PPD's impact on fathers, mothers, and children, benefiting mental health and well-being. © 2024 Walter de Gruyter GmbH, Berlin/Boston.Review Citation - WoS: 4Citation - Scopus: 7Optimizing Lighting Design in Educational Settings for Enhanced Cognitive Performance: a Literature Review(Elsevier Science Sa, 2025) Celik, Meric; Didikoglu, Altug; Kazanasmaz, TugceLighting has more functions than simply illuminating spaces. For humans, light is the main signal that aligns our body's internal clock, regulating circadian rhythms. This process instructs our bodies to wake up in the morning, become alert during the day, and feel sleepy at night. Disruption of these rhythms can impact neurological and psychiatric health, including cognitive performance. We can utilize light for mood improvements and better cognitive performance to create a suitable learning environment for students in educational buildings. These non-visual effects of light need to be considered from the beginning of the design process, making an interdisciplinary effort necessary. Even with adequate light and dark, the human eye reacts differently under various conditions, influenced by light's photometric and colorimetric properties. While natural sunlight is ideal for aligning with our biological clock, it is not always sufficient, making artificial lighting essential indoors. LED technology offers promising solutions, catering to our non-visual needs in the absence of natural light and providing energy efficiency. This study reviews the literature that includes students' cognitive performance and well-being, energy efficiency, running costs, and environment-related issues such as light pollution. It aims to explore the impact of lighting design in learning environments.Article Citation - WoS: 9Citation - Scopus: 8Depression in Older Adults and Its Associations With Sleep and Synaptic Density(Elsevier, 2024) Didikoglu, Altug; Guler, Esin Simge; Turk, Halil Kaan; Can, Kubilay; Erim, Aleyna Nur; Payton, Antony; Maharani, AsriBackground: Depression among older adults is a global concern, contributing to disability and overall illness burden. Understanding its trajectory, associated risk factors, and implications for mortality is essential for effective intervention. Moreover, the relationship between depression, sleep disturbances, and synaptic density in the ageing brain remains complex and poorly understood. Methods: Using data from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age cohort, comprising 6375 participants, we conducted comprehensive assessments of depression trajectories using generalized linear mixed models and mortality risks using Cox mixed-effects models. Generalized structural equation modelling was performed to explore longitudinal associations between sleep duration and depression. Lastly, associations between post-mortem synaptic density and depression were investigated. Results: Our findings revealed that depression rates declined until age 80 before increasing again. Depression was associated with a 10 % increased risk of mortality in older adults. Reduced sleep was correlated with depression, and depression measured early in the study predicted future reduced sleep. Post-mortem analysis showed a global reduction in synaptic density associated with depression, particularly pronounced in the frontal lobe. Limitations: Limitations include recall bias, limiting generalizability due to dominantly including White British participants and difficulty in establishing causation between synaptic density and depression. Conclusion: Our study underscores the significance of addressing depression in older adults, not only for mental health but also for mortality risk and neurobiological health. Early detection and intervention strategies are crucial for improving outcomes in elderly populations, potentially mitigating adverse effects on sleep, synaptic density, cognitive health, and longevity.Article Assessment of the Validity and Reliability of Edinburgh Postpartum Depression Scale in Turkish Men(2024) Alkan, Çiğdem; Didikoğlu, Altuğ; Çöme, Oğulcan; Yılmaz, Betül; Mevsim, VildanObjectives Perinatal depression (PD) affects individuals during pregnancy and early parenthood, resembling major depression. Recent research highlights paternal perinatal depression (PPD) in fathers. PPD has adverse effects on fathers and their children. This study assesses the Turkish version of the Edinburgh Postnatal Depression Scale (EPDS) for Turkish fathers, aiming to provide a tool for PPD identification. Methods This methodological study validates the EPDS for Turkish fathers and explores associations with demographic and psychosocial factors. The study involved 295 fathers with infants aged 2 weeks to 12 months. The EPDS, originally designed for perinatal depression and validated in Turkish women, was used. Fathers completed a participant information questionnaire, the EPDS, and the Beck Depression Inventory (BDI) during clinic visits. Data on sociodemographic factors, paternal roles, and pregnancy and postpartum support were collected. Mothers also completed the EPDS. Descriptive statistics, exploratory factor analysis, confirmatory factor analysis, and correlation tests were used. Results The study included fathers with an average age of 30.5 years, mostly with a high school education or higher. The EPDS had a mean total score of 3.1. Factor analysis suggested a three-factor structure for the EPDS in Turkish fathers, including anhedonia, anxiety, and depression. Confirmatory factor analysis validated the three-factor structure, with acceptable model fit indices. Positive correlations were found between fathers’ EPDS scores, maternal EPDS scores, and paternal BDI scores. The EPDS effectively discriminated between different levels of depression severity. Various factors, such as education level and lack of support during pregnancy and after childbirth, were associated with higher EPDS scores. Conclusions These findings emphasize the significance of assessing and addressing PPD in fathers, supporting the use of the EPDS as a valid tool in the Turkish context. The three-factor structure aligns with international research, highlighting the importance of a multi-dimensional approach to PPD assessment. Early intervention can mitigate PPD’s impact on fathers, mothers, and children, benefiting mental health and well-being.Review Citation - WoS: 24Citation - Scopus: 27Recommendations for Measuring and Standardizing Light for Laboratory Mammals To Improve Welfare and Reproducibility in Animal Research(Public Library Science, 2024) Lucas, Robert J.; Allen, Annette E.; Brainard, George C.; Brown, Timothy M.; Dauchy, Robert T.; Didikoglu, Altug; Peirson, Stuart N.Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals enter experiments in an appropriate physiological and behavioral state. Furthermore, proper consideration of light during experimentation is important both when it is explicitly employed as an independent variable and as a general feature of the environment. This Consensus View discusses metrics to use for the quantification of light appropriate for nonhuman mammals and their application to improve animal welfare and the quality of animal research. It provides methods for measuring these metrics, practical guidance for their implementation in husbandry and experimentation, and quantitative guidance on appropriate light exposure for laboratory mammals. The guidance provided has the potential to improve data quality and contribute to reduction and refinement, helping to ensure more ethical animal use. Lighting conditions for laboratory mammals is currently set according to the sensitivity of human vision. This Consensus View defines alternative 'animal-centric' metrics and provides guidance for their application to standardize experimental conditions, improve animal welfare and the quality of animal research.Article Citation - WoS: 33Citation - Scopus: 30Associations Between Light Exposure and Sleep Timing and Sleepiness While Awake in a Sample of Uk Adults in Everyday Life(Natl Acad Sciences, 2023) Didikoglu, Altug; Mohammadian, Navid; Johnson, Sheena; van Tongeren, Martie; Wright, Paul; Casson, Alexander J.; Lucas, Robert J.; Didikoğlu, AltuğExperimental and interventional studies show that light can regulate sleep timing and sleepiness while awake by setting the phase of circadian rhythms and supporting alertness. The extent to which differences in light exposure explain variations in sleep and sleepiness within and between individuals in everyday life remains less clear. Here, we establish a method to address this deficit, incorporating an open- source wearable wrist -worn light logger (SpectraWear) and smartphone-based online data collection. We use it to simultaneously record longitudinal light exposure (in melanopic equivalent daylight illuminance), sleep timing, and subjective alertness over seven days in a convenience sample of 59 UK adults without externally imposed circadian challenge (e.g., shift work or jetlag). Participants reliably had strong daily rhythms in light exposure but frequently were exposed to less light during the daytime and more light in pre- bedtime and sleep episodes than recommended [T. M. Brown et al., PLoS Biol. 20, e3001571 (2022)]. Prior light exposure over several hours was associated with lower subjective sleepiness with, in particular, brighter light in the late sleep episode and after wake linked to reduced early morning sleepiness (sleep inertia). Higher pre- bedtime light exposure was associated with longer sleep onset latency. Early sleep timing was correlated with more reproducible and robust daily patterns of light exposure and higher daytime/lower night -time light exposure. Our study establishes a method for collecting longitudinal sleep and health/performance data in everyday life and provides evidence of associations between light exposure and important determinants of sleep health and performance.Article Citation - WoS: 4Citation - Scopus: 3Protocol for a prospective, multicentre, cross-sectional cohort study to assess personal light exposure(Bmc, 2024) Guidolin, Carolina; Aerts, Sam; Agbeshie, Gabriel Kwaku; Akuffo, Kwadwo Owusu; Aydın, Sema Nur; Baeza-Moyano, David; Spitschan, Manuel; Didikoğlu, AltuğLight profoundly impacts many aspects of human physiology and behaviour, including the synchronization of the circadian clock, the production of melatonin, and cognition. These effects of light, termed the non-visual effects of light, have been primarily investigated in laboratory settings, where light intensity, spectrum and timing can be carefully controlled to draw associations with physiological outcomes of interest. Recently, the increasing availability of wearable light loggers has opened the possibility of studying personal light exposure in free-living conditions where people engage in activities of daily living, yielding findings associating aspects of light exposure and health outcomes, supporting the importance of adequate light exposure at appropriate times for human health. However, comprehensive protocols capturing environmental (e.g., geographical location, season, climate, photoperiod) and individual factors (e.g., culture, personal habits, behaviour, commute type, profession) contributing to the measured light exposure are currently lacking. Here, we present a protocol that combines smartphone-based experience sampling (experience sampling implementing Karolinska Sleepiness Scale, KSS ratings) and high-quality light exposure data collection at three body sites (near-corneal plane between the two eyes mounted on spectacle, neck-worn pendant/badge, and wrist-worn watch-like design) to capture daily factors related to individuals' light exposure. We will implement the protocol in an international multi-centre study to investigate the environmental and socio-cultural factors influencing light exposure patterns in Germany, Ghana, Netherlands, Spain, Sweden, and Turkey (minimum n = 15, target n = 30 per site, minimum n = 90, target n = 180 across all sites). With the resulting dataset, lifestyle and context-specific factors that contribute to healthy light exposure will be identified. This information is essential in designing effective public health interventions.Article Citation - WoS: 4Citation - Scopus: 4Measuring Light Exposure in Daily Life: a Review of Wearable Light Loggers(Pergamon-elsevier Science Ltd, 2025) van Duijnhoven, J.; Hartmeyer, S. L.; Didikoglu, A.; Stefani, O.; Houser, K. W.; Kalavally, V.; Spitschan, M.Wearable light loggers are increasingly available for various applications, including consumer, research and clinical contexts. This study employed a survey design to systematically outline available wearable light loggers, focusing on their key characteristics and usability. Through expert meetings and iterative discussions, we developed a comprehensive survey instrument covering device properties, sensor characteristics, calibration methods, and applications. Data were collected from manufacturer-provided information and public sources for 53 wearable light loggers. Our findings highlight the diversity among wearable light loggers in terms of their device characteristics. A notable increase in the number and sophistication of wearable light loggers is visible over the past decade. However, the variability in the quality and completeness of reported device performance and validation methods emphasizes the importance of standardized practices and improved collaboration between researchers and manufacturers to enhance the reliability and usability of wearable light logging technologies in scientific research.Article Citation - WoS: 1Citation - Scopus: 1Light-Dark and Activity Rhythm Therapy (l-Dart) To Improve Sleep in People With Schizophrenia Spectrum Disorders: a Single-Group Mixed Methods Study of Feasibility, Acceptability and Adherence(MDPI, 2023) Faulkner, Sophie; Didikoğlu, Altuğ; Byrne, Rory; Drake, Richard; Bee, PennyPeople with a diagnosis of schizophrenia often have poor sleep, even when their psychotic symptoms are relatively well managed. This includes insomnia, sleep apnoea, hypersomnia, and irregular or non-24 h sleep-wake timing. Improving sleep would better support recovery, yet few evidence-based sleep treatments are offered to this group. This paper presents a mixed methods feasibility and acceptability study of Light-Dark and Activity Rhythm Therapy (L-DART). L-DART is delivered by an occupational therapist over 12 weeks. It is highly personalisable to sleep phenotypes and circumstances. Ten participants with schizophrenia spectrum diagnoses and sleep problems received L-DART; their sleep problems and therapy goals were diverse. We measured recruitment, attrition, session attendance, and adverse effects, and qualitatively explored acceptability, engagement, component delivery, adherence, activity patterns, dynamic light exposure, self-reported sleep, wellbeing, and functioning. Recruitment was ahead of target, there was no attrition, and all participants received the minimum 'dose' of sessions. Acceptability assessed via qualitative reports and satisfaction ratings was good. Adherence to individual intervention components varied, despite high participant motivation. All made some potentially helpful behaviour changes. Positive sleep and functioning outcomes were reported qualitatively as well as in outcome measures. The findings above support testing the intervention in a larger randomised trial ISRCTN11998005.