Hoşer, Ezgi

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https://hdl.handle.net/11147/16125
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01. Izmir Institute of Technology
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Sustainable Development Goals

NO POVERTY1
NO POVERTY
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ZERO HUNGER2
ZERO HUNGER
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GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
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QUALITY EDUCATION4
QUALITY EDUCATION
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GENDER EQUALITY5
GENDER EQUALITY
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CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
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AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
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DECENT WORK AND ECONOMIC GROWTH8
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INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
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REDUCED INEQUALITIES10
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SUSTAINABLE CITIES AND COMMUNITIES11
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RESPONSIBLE CONSUMPTION AND PRODUCTION12
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CLIMATE ACTION13
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LIFE BELOW WATER14
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LIFE ON LAND15
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
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PARTNERSHIPS FOR THE GOALS17
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Supervised PhD Theses

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  • Doctoral Thesis
    Investigation of Compensatory Effect of Copper Mineral and Iron-Protein Complexes on Iron Deficiency Anemia in Human Enterocyte Cell Culture Model
    (Izmir Institute of Technology, 2021) Hoşer, Ezgi; Yemenicioğlu, Ahmet; Güleç, Şükrü; Hoşer, Ezgi; Evcan, Ezgi; Güleç, Şükrü; Yemenicioğlu, Ahmet; 03.08. Department of Food Engineering; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    Iron deficiency is the most encountered worldwide nutritional disease, affecting women, babies, and children. When dietary iron absorption is insufficient to fulfill physiological demands, nutritional iron insufficiency arises. Legumes are a low-cost source of protein that are also beneficial for human health. From a nutritional standpoint, the iron-chelating ability of legume proteins is of importance since they may have high iron mineral stability against in vitro digestion because they are bound to proteins. Legume proteins extracts are commonly utilized as functional components; however, their functionality must be proved in a cell culture system by assessing their physiological activity. Furthermore, during iron deprivation disturbances in copper homeostasis have been observed repeatedly in the literature. And this pointed out that copper might have a compensatory effect on anemia caused by iron deficiency dependant cellular signaling mechanisms. Within this context, the main objectives of this Ph.D. thesis were (i) to develop highly bioavailable, edible protein-iron complex hydrolysates from legumes that can be used as an additive in food products and investigate their functional properties against iron deficiency anemia. Also, (ii) investigating the compensatory effects of copper mineral on iron deficiency anemia and, (iii) its main application for functional food development were other driving forces for the experiments. It was revealed that protein (peptide)-iron complexes derived from lentil (10:1 ratio) and soybean (20:1 and 40:1 ratios) significantly influenced the iron-dependent gene regulation in enterocyte cells compared to the anemic group. Moreover, intracellular gene regulation was mainly affected by copper treatment in the basolateral side of enterocyte cells during IDA, indicating that blood copper level might have the ability to control the enterocyte iron metabolism at molecular and genetic levels during iron deficiency anemia.