Aydın, Beyza Sultan

Profile URL
https://hdl.handle.net/11147/16545
Name Variants
Job Title
Email Address
Main Affiliation
04.03. Department of Molecular Biology and Genetics
Status
Current Staff
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Scopus Author ID
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WoS Researcher ID

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Scholarly Output

2

Articles

2

Views / Downloads

6287/807

Supervised MSc Theses

0

Supervised PhD Theses

0

WoS Citation Count

14

Scopus Citation Count

14

Patents

0

Projects

0

WoS Citations per Publication

7.00

Scopus Citations per Publication

7.00

Open Access Source

2

Supervised Theses

0

JournalCount
Acta Chromatographica1
Journal of Chemical Metrology1
Current Page: 1 / 1

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Author of Publication: search.filters.isAuthorOfPublication.a946c109-9cfb-41bf-97ed-58dee4c19238

Scholarly Output Search Results

Now showing 1 - 2 of 2
  • Article
    Citation - WoS: 6
    Citation - Scopus: 6
    A Comparative Study of Hplc and Uv Spectrophotometric Methods for Oseltamivir Quantification in Pharmaceutical Formulations
    (Akademiai Kiado, 2022) Güngör, Serdar; Aydın, Beyza Sultan; Aydın, Beyza Sultan; İlikçi Sağkan, Rahşan; 04.03. Department of Molecular Biology and Genetics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Oseltamivir is an antiviral drug and is used in the treatment of all influenza viruses. It is the most effective antiviral option against all influenza viruses that can infect humans. UV and LC methods have been developed and validated according to ICH guidelines for various parameters like selectivity, linearity, accuracy, precision, LOD and LOQ, robustness for the quantitative determination of oseltamivir in pharmaceutical formulations. LC method has been performed using reverse phase technique on a C-18 column with a mobile phase consisting of 20 mM potassium dihydrogen phosphate solution and acetonitrile (60:40, v/v) at 25 8C. The mobile phase flow rate was 1.2 mL min-1. For the determination of oseltamivir, UV spectrum has been recorded between 200 and 800 nm using methanol as solvent and the wavelength of 215 nm has been selected. Both methods have demonstrated good linearity, precision and recovery. No spectral and chromatographic interferences from the capsule excipients were found in UV and LC methods. In both methods, correlation coefficients were greater than 0.999 within a concentration range of 10???60 mg mL-1 using UV and LC. Intra-day and inter-day precision with low relative standard deviation values were observed. The accuracy of these methods was within the range 99.85???100.17% for LC and from 99.26 to 100.70% for UV. Therefore UV and LC methods gave the most reliable outcomes for the determination of oseltamivir in pharmaceutical formulation.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 8
    Simple High-Performance Liquid Chromatographic Method for Determination of Donepezil Hcl in Pharmaceutical Formulations
    (ACG Publications, 2020) Aydın, Beyza Sultan; Aydın, Beyza Sultan; 04.03. Department of Molecular Biology and Genetics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Donepezil HCl is a hydrochloride salt of a piperidine derivative acetylcholinesterase inhibitor and, it uses in treatment demantia of Alzheimer’s disease. In this study, a sensitive and rapid HPLC-UV method was developed and validated for determination of Donepezil HCl in API and tablet dosage forms. Chromatographic separation was performed using a Ace 5 C18 (5 ?m, 250 x 4.6 mm) by using isocratic phosphate buffer at pH:2.0 and acetonitrile (55:45, v/v) mobile phase was used at the rate of 1.2 mL/min. The column temperature was set at 30 ?C and the UV detection was recorded at 268 nm. The method was validated with respect to specificity, precision, accuracy, linearity, repeatability and reproducibility parameters in a concentration range of 25-125 µg/mL. The limit of detection (LOD) and limit of quantification (LOQ) were determined as 1.40 and4.20 µg/mL, respectively. The uncertainty budget of the measurement for Donepezil HCl was estiamted as 5.80 % at 95% confidence level (k = 2).