Revealing Genome-Wide Mrna and Microrna Expression Patterns in Leukemic Cells Highlighted “hsa-Mir as a Tumor Suppressor for Regain of Chemotherapeutic Imatinib Response Due To Targeting Stat5a
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Authors
Adan Gökbulut, Aysun
Baran, Yusuf
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Open Access Color
GOLD
Green Open Access
Yes
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67
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126
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Abstract
BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to be overcome. In this study, we aimed to determine differing genome-wide microRNA (miRNA) and messenger RNA (mRNA) expression profiles in imatinib resistant (K562/IMA-3 μM) and parental cells by targeting STAT5A via small interfering RNA (siRNA) applications. After determining possible therapeutic miRNAs, we aimed to check their effects upon cell viability and proliferation, apoptosis, and find a possible miRNA
Description
Keywords
Apoptosis, Imatinib resistance, siRNA, STAT5A, Transcriptome and miRNome array, Chronic myeloid leukemia, MicroRNAs, Blotting, Western, Apoptosis, Real-Time Polymerase Chain Reaction, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Biomarkers, Tumor, STAT5 Transcription Factor, Tumor Cells, Cultured, Humans, RNA, Messenger, Imatinib resistance, RNA, Small Interfering, Protein Kinase Inhibitors, Cell Proliferation, Oligonucleotide Array Sequence Analysis, Gene Expression Regulation, Leukemic, Genome, Human, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Chronic myeloid leukemia, Transcriptome and miRNome array, STAT5A, MicroRNAs, Drug Resistance, Neoplasm, siRNA, Imatinib Mesylate
Fields of Science
0301 basic medicine, 03 medical and health sciences, 0303 health sciences
Citation
Tezcanlı Kaymaz, B., Selvi Günel, N., Ceyhan, M., Bozok Çetintaş, V., Özel, B., Kartal Yandım, M., Kıpçak, S., Aktan, Ç., Adan Gökbulut, A., Baran, Y., and Kosova Can, B. (2015). Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted “hsa-miR-2278” as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A. Tumor Biology, 36(10), 7915-7927. doi:10.1007/s13277-015-3509-9
WoS Q
Scopus Q
Q3
OpenCitations Citation Count
24
Source
Tumor Biology
Volume
36
Issue
10
Start Page
7915
End Page
7927
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CrossRef : 12
Scopus : 29
PubMed : 15
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