The Roles of Thiol Oxidoreductases in Yeast Replicative Aging
| dc.contributor.author | Hacıoğlu, Elise | |
| dc.contributor.author | Esmer, Işıl | |
| dc.contributor.author | Fomenko, Dmitri E. | |
| dc.contributor.author | Gladyshev, Vadim N. | |
| dc.contributor.author | Koç, Ahmet | |
| dc.coverage.doi | 10.1016/j.mad.2010.09.006 | |
| dc.date.accessioned | 2016-12-14T12:07:10Z | |
| dc.date.available | 2016-12-14T12:07:10Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis. © 2010 Elsevier Ireland Ltd. | en_US |
| dc.description.sponsorship | DPT-2003K120690; TÜBA-GEBİP and NIH AG021518 | en_US |
| dc.identifier.citation | Hacıoğlu, E., Esmer, I., Fomenko, D. E., Gladyshev, V. N., and Koç, A. (2010). The roles of thiol oxidoreductases in yeast replicative aging. Mechanisms of Ageing and Development, 131(11-12), 692-699. doi:10.1016/j.mad.2010.09.006 | en_US |
| dc.identifier.doi | 10.1016/j.mad.2010.09.006 | en_US |
| dc.identifier.doi | 10.1016/j.mad.2010.09.006 | |
| dc.identifier.issn | 1872-6216 | |
| dc.identifier.issn | 0047-6374 | |
| dc.identifier.scopus | 2-s2.0-78649909154 | |
| dc.identifier.uri | http://doi.org/10.1016/j.mad.2010.09.006 | |
| dc.identifier.uri | https://hdl.handle.net/11147/2623 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd. | en_US |
| dc.relation.ispartof | Mechanisms of Ageing and Development | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Yeast | en_US |
| dc.subject | Oxidoreductase | en_US |
| dc.subject | Oxidation | en_US |
| dc.subject | Life span | en_US |
| dc.subject | Antioxidant | en_US |
| dc.subject | Aging | en_US |
| dc.title | The Roles of Thiol Oxidoreductases in Yeast Replicative Aging | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.institutional | Hacıoğlu, Elise | |
| gdc.author.institutional | Esmer, Işıl | |
| gdc.author.institutional | Koç, Ahmet | |
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| gdc.description.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
| gdc.description.endpage | 699 | en_US |
| gdc.description.issue | 11-12 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.startpage | 692 | en_US |
| gdc.description.volume | 131 | en_US |
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| gdc.identifier.openalex | W2067665458 | |
| gdc.identifier.pmid | 20934449 | |
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| gdc.oaire.keywords | Aging | |
| gdc.oaire.keywords | Protein Folding | |
| gdc.oaire.keywords | Saccharomyces cerevisiae Proteins | |
| gdc.oaire.keywords | Life span | |
| gdc.oaire.keywords | Water | |
| gdc.oaire.keywords | Cell Cycle Proteins | |
| gdc.oaire.keywords | Methyltransferases | |
| gdc.oaire.keywords | Saccharomyces cerevisiae | |
| gdc.oaire.keywords | Yeast | |
| gdc.oaire.keywords | Adenosine Triphosphate | |
| gdc.oaire.keywords | Thioredoxins | |
| gdc.oaire.keywords | Oxidoreductase | |
| gdc.oaire.keywords | Oxidation | |
| gdc.oaire.keywords | Mutation | |
| gdc.oaire.keywords | Antioxidant | |
| gdc.oaire.keywords | Cellular Senescence | |
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