The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
| dc.contributor.author | Rudzinska, Magdalena | |
| dc.contributor.author | Parodi, Alessandro | |
| dc.contributor.author | Soond, Surinder M. | |
| dc.contributor.author | Vinarov, Andrey Z. | |
| dc.contributor.author | Korolev, Dmitry O. | |
| dc.contributor.author | Morozov, Andrey O. | |
| dc.contributor.author | Zamyatnin, Andrey A., Jr. | |
| dc.contributor.author | Dağlıoğlu, Cenk | |
| dc.contributor.author | Tutar, Yusuf | |
| dc.coverage.doi | 10.3390/ijms20143602 | |
| dc.date.accessioned | 2020-07-25T22:12:44Z | |
| dc.date.available | 2020-07-25T22:12:44Z | |
| dc.date.issued | 2019 | |
| dc.description | PubMed: 31340550 | en_US |
| dc.description.abstract | Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology. | en_US |
| dc.identifier.doi | 10.3390/ijms20143602 | en_US |
| dc.identifier.issn | 1422-0067 | |
| dc.identifier.scopus | 2-s2.0-85069849261 | |
| dc.identifier.uri | https://doi.org/10.3390/ijms20143602 | |
| dc.identifier.uri | https://hdl.handle.net/11147/9506 | |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | en_US |
| dc.relation.ispartof | International Journal of Molecular Sciences | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Cysteine cathepsins | en_US |
| dc.subject | Cancer progression | en_US |
| dc.subject | Drug resistance | en_US |
| dc.title | The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.institutional | Dağlıoğlu, Cenk | |
| gdc.bip.impulseclass | C3 | |
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| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
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| gdc.description.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
| gdc.description.issue | 14 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.volume | 20 | en_US |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.openalex | W2963133779 | |
| gdc.identifier.pmid | 31340550 | |
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| gdc.oaire.influence | 5.019818E-9 | |
| gdc.oaire.isgreen | true | |
| gdc.oaire.keywords | Models, Molecular | |
| gdc.oaire.keywords | Cell Death | |
| gdc.oaire.keywords | Neovascularization, Pathologic | |
| gdc.oaire.keywords | Protein Conformation | |
| gdc.oaire.keywords | Cancer progression | |
| gdc.oaire.keywords | Antineoplastic Agents | |
| gdc.oaire.keywords | Review | |
| gdc.oaire.keywords | Cathepsins | |
| gdc.oaire.keywords | Cysteine cathepsins | |
| gdc.oaire.keywords | Extracellular Matrix | |
| gdc.oaire.keywords | Gene Expression Regulation, Neoplastic | |
| gdc.oaire.keywords | Proto-Oncogene Proteins c-bcl-2 | |
| gdc.oaire.keywords | Drug Resistance, Neoplasm | |
| gdc.oaire.keywords | Drug resistance | |
| gdc.oaire.keywords | Cell Line, Tumor | |
| gdc.oaire.keywords | Lymphatic Metastasis | |
| gdc.oaire.keywords | Neoplasms | |
| gdc.oaire.keywords | Animals | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Lysosomes | |
| gdc.oaire.keywords | Signal Transduction | |
| gdc.oaire.popularity | 8.131168E-8 | |
| gdc.oaire.publicfunded | false | |
| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 0303 health sciences | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
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