Hormones and the Breast: Local and Environmental Interactions
| dc.contributor.author | Brisken, C. | |
| dc.contributor.author | Rajaram, R. | |
| dc.contributor.author | Ayyannan, A. | |
| dc.contributor.author | Beleut, M. | |
| dc.contributor.author | Yalçın, Özden | |
| dc.coverage.doi | 10.1158/0008-5472.SABCS12-PL-1 | |
| dc.date.accessioned | 2021-01-24T18:31:52Z | |
| dc.date.available | 2021-01-24T18:31:52Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | A woman's reproductive history affects her risk to get breast cancer. In particular, the number of menstrual cycles she experiences correlates with risk. We use tissue recombination experiments and different mouse mutant models to discern the roles of the ovarian hormones estrogens and progesterone act in the mammary gland. While estrogens drive pubertal development, progesterone is the major driver of proliferation in the adult mammary epithelium. Both steroids rely strongly on paracrine signaling to elicit cell proliferation and other biological effects. | en_US |
| dc.identifier.doi | 10.1158/0008-5472.SABCS12-PL-1 | en_US |
| dc.identifier.issn | 0008-5472 | |
| dc.identifier.issn | 1538-7445 | |
| dc.identifier.uri | https://doi.org/10.1158/0008-5472.SABCS12-PL-1 | |
| dc.identifier.uri | https://hdl.handle.net/11147/9986 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Association for Cancer Research | en_US |
| dc.relation.ispartof | Cancer Research | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Hormones and the Breast: Local and Environmental Interactions | en_US |
| dc.type | Conference Object | en_US |
| dspace.entity.type | Publication | |
| gdc.author.institutional | Yalçın, Özden | |
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| gdc.description.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
| gdc.description.endpage | 1 | |
| gdc.description.publicationcategory | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.startpage | PL | |
| gdc.description.volume | 72 | en_US |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.openalex | W2011606976 | |
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