Benzodiazepine Derivatives From Marine-Derived Streptomyces Cacaoi 14cm034
| dc.contributor.author | Çetinel Aksoy, Semiha | |
| dc.contributor.author | Küçüksolak, Melis | |
| dc.contributor.author | Uzel, Ataç | |
| dc.contributor.author | Bedir, Erdal | |
| dc.date.accessioned | 2021-11-06T09:49:34Z | |
| dc.date.available | 2021-11-06T09:49:34Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | 7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D-(H-1 and C-13 NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study. | en_US |
| dc.description.sponsorship | This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 109S361) and EBILTEM (2012/BIL/028). | en_US |
| dc.identifier.doi | 10.25135/rnp.203.20.08.1766 | |
| dc.identifier.issn | 1307-6167 | |
| dc.identifier.scopus | 2-s2.0-85108653316 | |
| dc.identifier.uri | https://doi.org/10.25135/rnp.203.20.08.1766 | |
| dc.identifier.uri | https://hdl.handle.net/11147/11474 | |
| dc.language.iso | en | en_US |
| dc.publisher | ACG Publications | en_US |
| dc.relation.ispartof | Records of Natural Products | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Marine actinobacterium | en_US |
| dc.subject | Streptomyces cacaoi | en_US |
| dc.subject | Benzodiazepine | en_US |
| dc.subject | Antimicrobial activity | en_US |
| dc.subject | Antibiotics | en_US |
| dc.title | Benzodiazepine Derivatives From Marine-Derived Streptomyces Cacaoi 14cm034 | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | 0000-0003-1262-063X | |
| gdc.author.id | 0000-0003-1262-063X | en_US |
| gdc.author.institutional | Küçüksolak, Melis | |
| gdc.author.institutional | Bedir, Erdal | |
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| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.collaboration.industrial | false | |
| gdc.description.department | İzmir Institute of Technology. Bioengineering | en_US |
| gdc.description.endpage | 607 | en_US |
| gdc.description.issue | 6 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q3 | |
| gdc.description.startpage | 602 | en_US |
| gdc.description.volume | 15 | en_US |
| gdc.description.wosquality | Q3 | |
| gdc.identifier.openalex | W3169474846 | |
| gdc.identifier.trdizinid | 464301 | |
| gdc.identifier.wos | WOS:000658306500015 | |
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| gdc.oaire.influence | 2.8082583E-9 | |
| gdc.oaire.isgreen | true | |
| gdc.oaire.keywords | Streptomyces cacaoi | |
| gdc.oaire.keywords | antimicrobial activity | |
| gdc.oaire.keywords | Pyrrolobenzodiazepine | |
| gdc.oaire.keywords | Constituents | |
| gdc.oaire.keywords | Dna | |
| gdc.oaire.keywords | Marine actinobacterium | |
| gdc.oaire.keywords | benzodiazepine | |
| gdc.oaire.keywords | Biosynthesis | |
| gdc.oaire.keywords | antibiotics | |
| gdc.oaire.popularity | 6.639511E-9 | |
| gdc.oaire.publicfunded | false | |
| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 0303 health sciences | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
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| gdc.scopus.citedcount | 6 | |
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| local.message.claim | 2022-06-08T12:08:02.861+0300 | * |
| local.message.claim | |rp02870 | * |
| local.message.claim | |submit_approve | * |
| local.message.claim | |dc_contributor_author | * |
| local.message.claim | |None | * |
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