A Selective Bodipy-Based Fluorescent Sensor for the Detection of Cu2+ Ions in Biological and Environmental Samples
| dc.contributor.author | Eldem, Asli | |
| dc.contributor.author | Kibris, Erman | |
| dc.contributor.author | Ucuncu, Muhammed | |
| dc.date.accessioned | 2025-03-25T22:55:42Z | |
| dc.date.available | 2025-03-25T22:55:42Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | In this study, we present the design, synthesis, and characterization of a 'turn-on' fluorescent probe, BOD-HDZ, for the selective detection of Cu2+ ions in semi-aqueous solutions, environmental samples (water and soil), and MCF-7 cancer cells. BOD-HDZ was synthesized by functionalizing meso-formyl-BODIPY (BOD-ALD) with a 2-hydrazinopyridine, resulting in fluorescence quenching via a photoinduced electron transfer (PET) mechanism. The 1:1 coordination between Cu2+ and the probe was confirmed through Job's plot analysis and 1H NMR spectroscopy, leading to a 210-fold fluorescence enhancement at 515 nm. BOD-HDZ demonstrated exceptional sensing properties, including a rapid response time (<1 min), a broad operational pH range (2-12), and high sensitivity with a detection limit of 141 nM. | en_US |
| dc.description.sponsorship | Izmir Katip Celebi University Scientific Research Projects Coordination Unit [2021-GAP-ECZF-0018] | en_US |
| dc.description.sponsorship | Authors would like to acknowledge funding provided by Izmir Katip Celebi University Scientific Research Projects Coordination Unit Grant number 2021-GAP-ECZF-0018. Authors thank Optical Imaging Core Facilities in Izmir Biomedicine and Genome Center. | en_US |
| dc.identifier.doi | 10.1016/j.saa.2025.125909 | |
| dc.identifier.issn | 1386-1425 | |
| dc.identifier.issn | 1873-3557 | |
| dc.identifier.scopus | 2-s2.0-85217903459 | |
| dc.identifier.uri | https://doi.org/10.1016/j.saa.2025.125909 | |
| dc.identifier.uri | https://hdl.handle.net/11147/15438 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pergamon-elsevier Science Ltd | en_US |
| dc.relation.ispartof | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Bodipy | en_US |
| dc.subject | Cu2+ Sensing | en_US |
| dc.subject | Cell Imaging | en_US |
| dc.subject | Real Water Samples | en_US |
| dc.subject | Soil Samples | en_US |
| dc.title | A Selective Bodipy-Based Fluorescent Sensor for the Detection of Cu2+ Ions in Biological and Environmental Samples | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.wosid | Üçüncü, Muhammed/Goe-5921-2022 | |
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| gdc.description.department | İzmir Institute of Technology | en_US |
| gdc.description.departmenttemp | [Eldem, Asli; Kibris, Erman; Ucuncu, Muhammed] Izmir Inst Technol, Fac Sci, Dept Chem, Izmir, Turkiye | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.volume | 333 | en_US |
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| gdc.identifier.pmid | 39970830 | |
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| gdc.oaire.keywords | Boron Compounds | |
| gdc.oaire.keywords | Ions | |
| gdc.oaire.keywords | Soil | |
| gdc.oaire.keywords | Spectrometry, Fluorescence | |
| gdc.oaire.keywords | Limit of Detection | |
| gdc.oaire.keywords | MCF-7 Cells | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Water | |
| gdc.oaire.keywords | Hydrogen-Ion Concentration | |
| gdc.oaire.keywords | Copper | |
| gdc.oaire.keywords | Fluorescent Dyes | |
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