Bioactive Sphingolipids in Docetaxel-Induced Apoptosis in Human Prostate Cancer Cells
| dc.contributor.author | Başsoy, Esen Yonca | |
| dc.contributor.author | Baran, Yusuf | |
| dc.coverage.doi | 10.1016/j.biopha.2011.10.003 | |
| dc.date.accessioned | 2017-02-10T07:01:16Z | |
| dc.date.available | 2017-02-10T07:01:16Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | In this study, we examined the possible roles of ceramide/sphingosine-1-phosphate and ceramide/glucosyleceramide signaling in docetaxel-induced apoptosis by examining expression levels of the glucosyleceramide synthase and sphingosine kinase-1 and ceramide synthase gene family. As confirmed by isobologram analysis, docetaxel in combination with agents that increase intracellular ceramide levels increased the cytotoxic and apoptotic effects of docetaxel synergistically. More importantly, RT-PCR results revealed that expression levels of glucosyleceramide synthase and sphingosine kinase-1 were downregulated and ceramide synthase genes were upregulated in response to docetaxel. This study identifies mechanisms underlying the involvement of ceramide metabolizing genes in docetaxel-induced apoptosis in prostate cancer cells. © 2012 Elsevier Masson SAS. | en_US |
| dc.description.sponsorship | TUBITAK project number 109S215 and Turkish Academy of Sciences Outstanding Young Investigator Programme | en_US |
| dc.identifier.citation | Başsoy, E. Y., and Baran, Y. (2012). Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. Biomedicine and Pharmacotherapy, 66(2), 103-110. doi:10.1016/j.biopha.2011.10.003 | en_US |
| dc.identifier.doi | 10.1016/j.biopha.2011.10.003 | en_US |
| dc.identifier.doi | 10.1016/j.biopha.2011.10.003 | |
| dc.identifier.issn | 0753-3322 | |
| dc.identifier.scopus | 2-s2.0-84858287935 | |
| dc.identifier.uri | http://doi.org/10.1016/j.biopha.2011.10.003 | |
| dc.identifier.uri | https://hdl.handle.net/11147/4826 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd. | en_US |
| dc.relation.ispartof | Biomedicine and Pharmacotherapy | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Bioactive sphingolipids | en_US |
| dc.subject | Ceramides | en_US |
| dc.subject | Docetaxel | en_US |
| dc.subject | Glucosyle ceramide synthase | en_US |
| dc.subject | Prostate cancer | en_US |
| dc.subject | Sphingosine kinase | en_US |
| dc.title | Bioactive Sphingolipids in Docetaxel-Induced Apoptosis in Human Prostate Cancer Cells | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.institutional | Başsoy, Esen Yonca | |
| gdc.author.institutional | Baran, Yusuf | |
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| gdc.description.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
| gdc.description.endpage | 110 | en_US |
| gdc.description.issue | 2 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.startpage | 103 | en_US |
| gdc.description.volume | 66 | en_US |
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| gdc.identifier.pmid | 22326625 | |
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| gdc.oaire.keywords | Male | |
| gdc.oaire.keywords | Down-Regulation | |
| gdc.oaire.keywords | Antineoplastic Agents | |
| gdc.oaire.keywords | Apoptosis | |
| gdc.oaire.keywords | Docetaxel | |
| gdc.oaire.keywords | Ceramides | |
| gdc.oaire.keywords | Glucosylceramides | |
| gdc.oaire.keywords | Sphingosine kinase | |
| gdc.oaire.keywords | Sphingosine | |
| gdc.oaire.keywords | Cell Line, Tumor | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Prostate cancer | |
| gdc.oaire.keywords | Reverse Transcriptase Polymerase Chain Reaction | |
| gdc.oaire.keywords | Prostatic Neoplasms | |
| gdc.oaire.keywords | Drug Synergism | |
| gdc.oaire.keywords | Glucosyle ceramide synthase | |
| gdc.oaire.keywords | Up-Regulation | |
| gdc.oaire.keywords | Gene Expression Regulation, Neoplastic | |
| gdc.oaire.keywords | Phosphotransferases (Alcohol Group Acceptor) | |
| gdc.oaire.keywords | Glucosyltransferases | |
| gdc.oaire.keywords | Bioactive sphingolipids | |
| gdc.oaire.keywords | Taxoids | |
| gdc.oaire.keywords | Lysophospholipids | |
| gdc.oaire.keywords | Oxidoreductases | |
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