Stat Pathway in the Regulation of Zoledronic Acid-Induced Apoptosis in Chronic Myeloid Leukemia Cells
| dc.contributor.author | Kiper, Hatice Demet | |
| dc.contributor.author | Tezcanlı Kaymaz, Burçin | |
| dc.contributor.author | Adan Gökbulut, Aysun | |
| dc.contributor.author | Selvi, Nur | |
| dc.contributor.author | Biray Avcı, Çığır | |
| dc.contributor.author | Kosova, Buket | |
| dc.contributor.author | İskender, Güniz | |
| dc.contributor.author | Kartal Yandım, Melis | |
| dc.contributor.author | Gündüz, Cumhur | |
| dc.contributor.author | Şahin, Fahri | |
| dc.contributor.author | Baran, Yusuf | |
| dc.contributor.author | Saydam, Güray | |
| dc.coverage.doi | 10.1016/j.biopha.2013.04.006 | |
| dc.date.accessioned | 2017-04-11T10:31:38Z | |
| dc.date.available | 2017-04-11T10:31:38Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies. © 2013 Elsevier Masson SAS. | en_US |
| dc.identifier.citation | Kiper, H. D., Tezcanlı Kaymaz, B., Adan Gökbulut, A., Selvi, N., Biray Avcı, Ç., Kosova, B., İskender, G., Kartal Yandım, M., Gündüz, C., Şahin, F., Baran, Y., and Saydam, G. (2013). STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells. Biomedicine and Pharmacotherapy, 67(6), 527-532. doi:10.1016/j.biopha.2013.04.006 | en_US |
| dc.identifier.doi | 10.1016/j.biopha.2013.04.006 | en_US |
| dc.identifier.doi | 10.1016/j.biopha.2013.04.006 | |
| dc.identifier.issn | 0753-3322 | |
| dc.identifier.issn | 0753-3322 | |
| dc.identifier.scopus | 2-s2.0-84880949133 | |
| dc.identifier.uri | http://doi.org/10.1016/j.biopha.2013.04.006 | |
| dc.identifier.uri | https://hdl.handle.net/11147/5285 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd. | en_US |
| dc.relation.ispartof | Biomedicine and Pharmacotherapy | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Zoledronic acid | en_US |
| dc.subject | Chronic myeloid leukemia | en_US |
| dc.subject | STATs | en_US |
| dc.subject | Messenger RNA | en_US |
| dc.title | Stat Pathway in the Regulation of Zoledronic Acid-Induced Apoptosis in Chronic Myeloid Leukemia Cells | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.institutional | Adan Gökbulut, Aysun | |
| gdc.author.institutional | İskender, Güniz | |
| gdc.author.institutional | Kartal Yandım, Melis | |
| gdc.author.institutional | Baran, Yusuf | |
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| gdc.description.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
| gdc.description.endpage | 532 | en_US |
| gdc.description.issue | 6 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.startpage | 527 | en_US |
| gdc.description.volume | 67 | en_US |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.openalex | W2051819087 | |
| gdc.identifier.pmid | 23725755 | |
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| gdc.oaire.keywords | Diphosphonates | |
| gdc.oaire.keywords | Messenger RNA | |
| gdc.oaire.keywords | Chronic myeloid leukemia | |
| gdc.oaire.keywords | Imidazoles | |
| gdc.oaire.keywords | Apoptosis | |
| gdc.oaire.keywords | Zoledronic Acid | |
| gdc.oaire.keywords | STATs | |
| gdc.oaire.keywords | STAT Transcription Factors | |
| gdc.oaire.keywords | Cell Line, Tumor | |
| gdc.oaire.keywords | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | K562 Cells | |
| gdc.oaire.keywords | Zoledronic acid | |
| gdc.oaire.keywords | Cell Proliferation | |
| gdc.oaire.keywords | Signal Transduction | |
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