Therapeutic Potentials of Inhibition of Jumonji C Domain-Containing Demethylases in Acute Myeloid Leukemia

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dc.contributor.author Koca, Duygu
dc.contributor.author Hastar, Nurcan
dc.contributor.author Engür, Selin
dc.contributor.author Kiraz, Yağmur
dc.contributor.author Ulu, Gizem Tuğçe
dc.contributor.author Çekdemir, Demet
dc.contributor.author Baran, Yusuf
dc.coverage.doi 10.4274/tjh.galenos.2019.2019.0083
dc.date.accessioned 2020-11-10T20:14:59Z
dc.date.available 2020-11-10T20:14:59Z
dc.date.issued 2020
dc.description.abstract Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression. Abnormal expression of histone demethylases is indicated in many types of cancer including AML. Although many commercial drugs are available to treat AML, an absolute cure has not been discovered yet. However, inhibition of demethylases could be a potential cure for AML. Methylstat is a chemical agent that inhibits the Jumonji C domain-containing demethylases. en_US
dc.identifier.doi 10.4274/tjh.galenos.2019.2019.0083 en_US
dc.identifier.issn 13007777
dc.identifier.issn 13085263
dc.identifier.issn 1300-7777
dc.identifier.scopus 2-s2.0-85080841319
dc.identifier.uri https://hdl.handle.net/11147/9678
dc.identifier.uri https://search.trdizin.gov.tr/yayin/detay/365130
dc.language.iso en en_US
dc.publisher Aves en_US
dc.relation TUBITAK en_US
dc.relation.ispartof Turkish journal of haematology : Official journal of Turkish Society of Haematology en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Acute myeloid leukemia en_US
dc.subject Methylstat en_US
dc.subject Jumonji C domain en_US
dc.subject Histone methylation en_US
dc.title Therapeutic Potentials of Inhibition of Jumonji C Domain-Containing Demethylases in Acute Myeloid Leukemia en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.institutional Koca, Duygu
gdc.author.institutional Hastar, Nurcan
gdc.author.institutional Kiraz, Yağmur
gdc.author.institutional Ulu, Gizem Tuğçe
gdc.author.institutional Baran, Yusuf
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gdc.bip.popularityclass C5
gdc.coar.access open access
gdc.coar.type text::journal::journal article
gdc.collaboration.industrial false
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Anadolu Üniversitesi en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Sakarya Üniversitesi en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.description.department İzmir Institute of Technology. Molecular Biology and Genetics en_US
gdc.description.endpage 12 en_US
gdc.description.issue 1 en_US
gdc.description.scopusquality Q3
gdc.description.startpage -5 en_US
gdc.description.volume 37 en_US
gdc.description.wosquality Q3
gdc.identifier.openalex W2999608793
gdc.identifier.pmid 31833715
gdc.identifier.trdizinid 365130
gdc.identifier.wos WOS:000514819900002
gdc.index.type WoS
gdc.index.type Scopus
gdc.index.type TR-Dizin
gdc.index.type PubMed
gdc.oaire.accesstype GOLD
gdc.oaire.diamondjournal false
gdc.oaire.downloads 4
gdc.oaire.impulse 1.0
gdc.oaire.influence 2.6682088E-9
gdc.oaire.isgreen true
gdc.oaire.keywords Jumonji Domain-Containing Histone Demethylases
gdc.oaire.keywords Antineoplastic Agents
gdc.oaire.keywords Apoptosis
gdc.oaire.keywords acute myeloid leukemia
gdc.oaire.keywords Methylation
gdc.oaire.keywords Jumonji C domain
gdc.oaire.keywords Histone methylation
gdc.oaire.keywords methylstat
gdc.oaire.keywords Histones
gdc.oaire.keywords Cell Line, Tumor
gdc.oaire.keywords Biomarkers, Tumor
gdc.oaire.keywords Humans
gdc.oaire.keywords Methylstat
gdc.oaire.keywords Diseases of the blood and blood-forming organs
gdc.oaire.keywords Protein Interaction Domains and Motifs
gdc.oaire.keywords histone methylation
gdc.oaire.keywords Molecular Targeted Therapy
gdc.oaire.keywords Membrane Potential, Mitochondrial
gdc.oaire.keywords Acute myeloid leukemia
gdc.oaire.keywords Dose-Response Relationship, Drug
gdc.oaire.keywords Caspase 3
gdc.oaire.keywords Cell Cycle
gdc.oaire.keywords jumonji c domain
gdc.oaire.keywords Matrix Metalloproteinases
gdc.oaire.keywords Gene Expression Regulation, Neoplastic
gdc.oaire.keywords Leukemia, Myeloid, Acute
gdc.oaire.keywords RC633-647.5
gdc.oaire.keywords Research Article
gdc.oaire.popularity 2.4026483E-9
gdc.oaire.publicfunded false
gdc.oaire.sciencefields 0301 basic medicine
gdc.oaire.sciencefields 03 medical and health sciences
gdc.oaire.views 9
gdc.openalex.collaboration National
gdc.openalex.fwci 0.20610202
gdc.openalex.normalizedpercentile 0.54
gdc.opencitations.count 1
gdc.plumx.mendeley 12
gdc.plumx.pubmedcites 1
gdc.plumx.scopuscites 6
gdc.scopus.citedcount 6
gdc.wos.citedcount 6
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local.message.claim |submit_approve *
local.message.claim |dc_contributor_author *
local.message.claim |None *
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