Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions
| dc.contributor.author | Dogan,E. | |
| dc.contributor.author | Kisim,A. | |
| dc.contributor.author | Bati-Ayaz,G. | |
| dc.contributor.author | Kubicek,G.J. | |
| dc.contributor.author | Pesen-Okvur,D. | |
| dc.contributor.author | Miri,A.K. | |
| dc.date.accessioned | 2022-08-15T18:24:30Z | |
| dc.date.available | 2022-08-15T18:24:30Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Microfluidic tumors-on-chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migratory behavior of tumor cells. In this review, the biological niches of the TME and cancer cell behavior focusing on the behavior of CSCs are summarized. Conventional cancer models such as 3D cultures and organoid models are reviewed. Opportunities for the incorporation of CSCs with tumors-on-chips are then discussed for creating tumor invasion models. Such models will represent a paradigm shift in the cancer community by allowing oncologists and clinicians to predict better which cancer patients will benefit from chemotherapy treatments. © 2021 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH. | en_US |
| dc.description.sponsorship | Camden Health Initiative; National Institutes of Health, NIH; Rowan University, (119Z109); Rowan University; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK | en_US |
| dc.identifier.doi | 10.1002/anbr.202100017 | |
| dc.identifier.issn | 2699-9307 | |
| dc.identifier.scopus | 2-s2.0-85117479519 | |
| dc.identifier.uri | https://doi.org/10.1002/anbr.202100017 | |
| dc.identifier.uri | https://hdl.handle.net/11147/12363 | |
| dc.language.iso | en | en_US |
| dc.publisher | John Wiley and Sons Inc | en_US |
| dc.relation.ispartof | Advanced NanoBiomed Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | cancer stem cells | en_US |
| dc.subject | microfluidics | en_US |
| dc.subject | tumor microenvironments | en_US |
| dc.subject | tumors-on-chips | en_US |
| dc.title | Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions | en_US |
| dc.type | Review | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | 0000-0003-1561-2547 | |
| gdc.author.id | 0000-0001-8333-4193 | |
| gdc.author.id | 0000-0003-1561-2547 | en_US |
| gdc.author.id | 0000-0001-8333-4193 | en_US |
| gdc.author.scopusid | 57220469961 | |
| gdc.author.scopusid | 35758606900 | |
| gdc.author.scopusid | 57195469345 | |
| gdc.author.scopusid | 25641259400 | |
| gdc.author.scopusid | 8638543200 | |
| gdc.author.scopusid | 16312909200 | |
| gdc.bip.impulseclass | C4 | |
| gdc.bip.influenceclass | C5 | |
| gdc.bip.popularityclass | C4 | |
| gdc.coar.access | open access | |
| gdc.coar.type | text::review | |
| gdc.collaboration.industrial | false | |
| gdc.description.department | Izmir Institute of Technology | en_US |
| gdc.description.departmenttemp | Dogan E., Department of Mechanical Engineering, Rowan University, Glassboro, 08028, NJ, United States; Kisim A., Department of Molecular Biology & Genetics, Izmir Institute of Technology, Gulbahce Kampusu, Urla, Izmir, 35430, Turkey; Bati-Ayaz G., Biotechnology and Bioengineering, Izmir Institute of Technology, Izmir, Turkey; Kubicek G.J., Department of Radiation Oncology, MD Anderson Cancer Center at Cooper, 2 Cooper Plaza, Camden, 08103, NJ, United States; Pesen-Okvur D., Department of Molecular Biology & Genetics, Izmir Institute of Technology, Gulbahce Kampusu, Urla, Izmir, 35430, Turkey, Biotechnology and Bioengineering, Izmir Institute of Technology, Izmir, Turkey; Miri A.K., Department of Mechanical Engineering, Rowan University, Glassboro, 08028, NJ, United States, School of Medical Engineering, Science, and Health, Rowan University, Camden, 08103, NJ, United States | en_US |
| gdc.description.issue | 11 | en_US |
| gdc.description.publicationcategory | Diğer | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.volume | 1 | en_US |
| gdc.description.wosquality | Q2 | |
| gdc.identifier.openalex | W3176214584 | |
| gdc.identifier.pmid | 34927168 | |
| gdc.identifier.wos | WOS:000782100200002 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed | |
| gdc.oaire.accesstype | GOLD | |
| gdc.oaire.diamondjournal | false | |
| gdc.oaire.impulse | 18.0 | |
| gdc.oaire.influence | 2.946016E-9 | |
| gdc.oaire.isgreen | true | |
| gdc.oaire.keywords | cancer stem cells | |
| gdc.oaire.keywords | tumor microenvironments | |
| gdc.oaire.keywords | microfluidics | |
| gdc.oaire.keywords | Medical technology | |
| gdc.oaire.keywords | R855-855.5 | |
| gdc.oaire.keywords | tumors-on-chips | |
| gdc.oaire.keywords | TP248.13-248.65 | |
| gdc.oaire.keywords | Biotechnology | |
| gdc.oaire.popularity | 1.8740916E-8 | |
| gdc.oaire.publicfunded | false | |
| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 0303 health sciences | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
| gdc.openalex.collaboration | International | |
| gdc.openalex.fwci | 1.57083905 | |
| gdc.openalex.normalizedpercentile | 0.8 | |
| gdc.openalex.toppercent | TOP 1% | |
| gdc.opencitations.count | 14 | |
| gdc.plumx.crossrefcites | 15 | |
| gdc.plumx.mendeley | 21 | |
| gdc.plumx.pubmedcites | 14 | |
| gdc.plumx.scopuscites | 22 | |
| gdc.scopus.citedcount | 22 | |
| gdc.wos.citedcount | 19 | |
| relation.isAuthorOfPublication.latestForDiscovery | 8e1732f3-2bf8-4231-b7a4-7e94b485eb97 | |
| relation.isOrgUnitOfPublication.latestForDiscovery | 9af2b05f-28ac-4003-8abe-a4dfe192da5e |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Advanced NanoBiomed Research.pdf
- Size:
- 2.5 MB
- Format:
- Adobe Portable Document Format