Protoporphyrin Ix-Loaded Magnetoliposomes as a Potential Drug Delivery System for Photodynamic Therapy: Fabrication, Characterization and in Vitro Study
| dc.contributor.author | Başoğlu, Harun | |
| dc.contributor.author | Bilgin, Mehmet Dinçer | |
| dc.contributor.author | Demir, Mustafa Muammer | |
| dc.coverage.doi | 10.1016/j.pdpdt.2015.12.010 | |
| dc.date.accessioned | 2016-07-13T11:15:20Z | |
| dc.date.available | 2016-07-13T11:15:20Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | Protoporphyrin IX (PpIX) is a well-known photosensitizer that has great potential for use in photodynamic therapy (PDT). However, aggregation behavior of PpIX in neutral water makes it inappropriate for physiological studies. PpIX-loaded magnetoliposomes (MLs) were fabricated to increase PpIX biocompatibility. PpIX-loaded ML physical properties were characterized, and PpIX-loaded ML drug release behavior was investigated under the influence of an external magnetic field and heat. Toxicity and photodynamic effects of the complex were also examined using in vitro experiments with MCF-7 human breast cancer cells. The magnetoliposomes were prepared with DPPC, DSPE-PEG2000 lipids and Fe3O4 nanoparticles. The toxicity and in vitro photodynamic effects of the PpIX-loaded MLs at various concentrations were studied using the MCF-7 cell line. | en_US |
| dc.description.sponsorship | TÜBİTAk (grant no: 112S958); Adnan Menderes University (grant no: TPF-13014) | en_US |
| dc.identifier.citation | Başoğlu, H., Bilgin, M. D., and Demir, M. M. (2016). Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study. Photodiagnosis and Photodynamic Therapy, 13, 81-90. doi:10.1016/j.pdpdt.2015.12.010 | en_US |
| dc.identifier.doi | 10.1016/j.pdpdt.2015.12.010 | |
| dc.identifier.doi | 10.1016/j.pdpdt.2015.12.010 | en_US |
| dc.identifier.issn | 1572-1000 | |
| dc.identifier.scopus | 2-s2.0-84960473615 | |
| dc.identifier.uri | https://doi.org/10.1016/j.pdpdt.2015.12.010 | |
| dc.identifier.uri | https://hdl.handle.net/11147/1893 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd. | en_US |
| dc.relation.ispartof | Photodiagnosis and Photodynamic Therapy | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Protoporphyrin IX | en_US |
| dc.subject | Magnetoliposomes | en_US |
| dc.subject | Iron oxide nanoparticles | en_US |
| dc.subject | Photodynamic therapy | en_US |
| dc.subject | MCF-7 cells | en_US |
| dc.title | Protoporphyrin Ix-Loaded Magnetoliposomes as a Potential Drug Delivery System for Photodynamic Therapy: Fabrication, Characterization and in Vitro Study | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | 0000-0003-1309-3990 | |
| gdc.author.id | 0000-0003-1309-3990 | en_US |
| gdc.author.institutional | Demir, Mustafa Muammer | |
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| gdc.description.department | İzmir Institute of Technology. Materials Science and Engineering | en_US |
| gdc.description.endpage | 90 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.startpage | 81 | en_US |
| gdc.description.volume | 13 | en_US |
| gdc.description.wosquality | Q3 | |
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| gdc.identifier.pmid | 26751701 | |
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| gdc.oaire.keywords | Protoporphyrin IX | |
| gdc.oaire.keywords | Cell Survival | |
| gdc.oaire.keywords | Drug Compounding | |
| gdc.oaire.keywords | Protoporphyrins | |
| gdc.oaire.keywords | Photodynamic therapy | |
| gdc.oaire.keywords | Diffusion | |
| gdc.oaire.keywords | Iron oxide nanoparticles | |
| gdc.oaire.keywords | Nanocapsules | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | MCF-7 cells | |
| gdc.oaire.keywords | Particle Size | |
| gdc.oaire.keywords | Magnetite Nanoparticles | |
| gdc.oaire.keywords | Magnetoliposomes | |
| gdc.oaire.keywords | Fabrication, characterization and in vitro study-, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, cilt.13, ss.81-90, 2016 [Basoglu H., Bilgin M. D. , Demir M. M. , -Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy] | |
| gdc.oaire.keywords | Photosensitizing Agents | |
| gdc.oaire.keywords | Body Fluids | |
| gdc.oaire.keywords | Treatment Outcome | |
| gdc.oaire.keywords | Photochemotherapy | |
| gdc.oaire.keywords | Delayed-Action Preparations | |
| gdc.oaire.keywords | Liposomes | |
| gdc.oaire.keywords | MCF-7 Cells | |
| gdc.oaire.keywords | Feasibility Studies | |
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