C-Met Activation Promotes Extravasation of Hepatocellular Carcinoma Cells Into 3d-Cultured Hepatocyte Cells in Lab-On Device
| dc.contributor.author | Solmaz, Gülhas | |
| dc.contributor.author | Bağcı, Gülsün | |
| dc.contributor.author | Çömez, Dehan | |
| dc.contributor.author | Topel, Hande | |
| dc.contributor.author | Yılmaz, Yeliz | |
| dc.contributor.author | Bağırsakçı, Ezgi | |
| dc.contributor.author | Güneş, Aysim | |
| dc.contributor.author | Batı Ayaz, Gizem | |
| dc.contributor.author | Tahmaz, İsmail | |
| dc.contributor.author | Bilgen, Müge | |
| dc.contributor.author | Pesen Okvur, Devrim | |
| dc.date.accessioned | 2023-10-03T07:16:29Z | |
| dc.date.available | 2023-10-03T07:16:29Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Activation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells. These results, thus, demonstrate the role of c-Met signaling in regulating the colonization of HCC cells preferentially in the liver. © 2023 Elsevier B.V. | en_US |
| dc.description.sponsorship | Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 115E056, TUBITAK1003 | en_US |
| dc.description.sponsorship | This work was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) with project code [TUBITAK1003, 115E056]. The authors acknowledge the members of the Optical Imaging Core Facility at Izmir Biomedicine and Genome Center, Dr. Melek Ucuncu and Didem Cimtay, for their support in taking images under Confocal Microscopy and Dr. Ozden Yalcin Ozuysal for her kind contribution on optimization of the EX-LOC device. Fig. 1 G, H, I, and Suppl. Fig. 1C, 1G made in BioRender. | en_US |
| dc.identifier.doi | 10.1016/j.bbamcr.2023.119557 | |
| dc.identifier.issn | 0167-4889 | |
| dc.identifier.scopus | 2-s2.0-85167568404 | |
| dc.identifier.uri | https://doi.org/10.1016/j.bbamcr.2023.119557 | |
| dc.identifier.uri | https://hdl.handle.net/11147/13830 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartof | Biochimica et Biophysica Acta - Molecular Cell Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | c-Met | en_US |
| dc.subject | Extravasation | en_US |
| dc.subject | HCC | en_US |
| dc.subject | Lab-on-a-chip | en_US |
| dc.subject | Metastasis | en_US |
| dc.subject | Microenvironment | en_US |
| dc.title | C-Met Activation Promotes Extravasation of Hepatocellular Carcinoma Cells Into 3d-Cultured Hepatocyte Cells in Lab-On Device | en_US |
| dc.type | Letter | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | 0000-0001-8333-4193 | |
| gdc.author.id | 0000-0001-8333-4193 | en_US |
| gdc.author.institutional | Batı Ayaz, Gizem | |
| gdc.author.institutional | Tahmaz, İsmail | |
| gdc.author.institutional | Bilgen, Müge | |
| gdc.author.institutional | Pesen Okvur, Devrim | |
| gdc.author.scopusid | 57218187410 | |
| gdc.author.scopusid | 57218188669 | |
| gdc.author.scopusid | 55603957400 | |
| gdc.author.scopusid | 57209089819 | |
| gdc.author.scopusid | 57196114387 | |
| gdc.author.scopusid | 56711697900 | |
| gdc.author.scopusid | 57195469345 | |
| gdc.bip.impulseclass | C5 | |
| gdc.bip.influenceclass | C5 | |
| gdc.bip.popularityclass | C5 | |
| gdc.coar.access | open access | |
| gdc.coar.type | text::letter | |
| gdc.collaboration.industrial | false | |
| gdc.description.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
| gdc.description.issue | 8 | en_US |
| gdc.description.publicationcategory | Diğer | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.volume | 1870 | en_US |
| gdc.description.wosquality | Q2 | |
| gdc.identifier.openalex | W4385680847 | |
| gdc.identifier.pmid | 37549739 | |
| gdc.identifier.wos | WOS:001066997400001 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed | |
| gdc.oaire.diamondjournal | false | |
| gdc.oaire.impulse | 2.0 | |
| gdc.oaire.influence | 2.8276952E-9 | |
| gdc.oaire.isgreen | true | |
| gdc.oaire.keywords | Microenvironment | |
| gdc.oaire.keywords | Carcinoma, Hepatocellular | |
| gdc.oaire.keywords | Lab-on-a-chip (LOC) | |
| gdc.oaire.keywords | Liver Neoplasms | |
| gdc.oaire.keywords | Hepatocytes | |
| gdc.oaire.keywords | Tumor Microenvironment | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | HCC | |
| gdc.oaire.keywords | Extravasation | |
| gdc.oaire.keywords | Metastasis | |
| gdc.oaire.keywords | c-Met | |
| gdc.oaire.keywords | Cell Line | |
| gdc.oaire.popularity | 2.5946283E-9 | |
| gdc.oaire.publicfunded | false | |
| gdc.openalex.collaboration | National | |
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| gdc.openalex.normalizedpercentile | 0.64 | |
| gdc.opencitations.count | 2 | |
| gdc.plumx.mendeley | 5 | |
| gdc.plumx.pubmedcites | 1 | |
| gdc.plumx.scopuscites | 2 | |
| gdc.scopus.citedcount | 2 | |
| gdc.wos.citedcount | 1 | |
| relation.isAuthorOfPublication.latestForDiscovery | 8e1732f3-2bf8-4231-b7a4-7e94b485eb97 | |
| relation.isOrgUnitOfPublication.latestForDiscovery | 9af2b05f-28ac-4013-8abe-a4dfe192da5e |
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