A New Semi-Synthetic Sapogenol Derivative Inducing Regulated Necrosis
| dc.contributor.author | Üner, Göklem | |
| dc.contributor.author | Bedir, Erdal | |
| dc.contributor.author | Ballar Kırmızıbayrak, Petek | |
| dc.contributor.author | Üner, Göklem | |
| dc.contributor.author | Bedir, Erdal | |
| dc.contributor.other | 03.01. Department of Bioengineering | |
| dc.contributor.other | 01. Izmir Institute of Technology | |
| dc.contributor.other | 03. Faculty of Engineering | |
| dc.coverage.doi | 10.1055/s-0039-3399943 | |
| dc.date.accessioned | 2020-07-25T22:10:43Z | |
| dc.date.available | 2020-07-25T22:10:43Z | |
| dc.date.issued | 2019 | |
| dc.description | 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- SEP 01-05, 2019 -- Innsbruck, AUSTRIA | en_US |
| dc.description.abstract | Since saponin’s antitumor potency is relatively weak, researchers focus on their semi-synthetic modification to obtain structures with higher potencies. With the same motivation, we prepared a cytotoxic sapogenol derivative (AG-08) from cycloastragenol. Our preliminary studies revealed that AG-08 induced primarily necrotic cell death along with autophagic inhibition. Furthermore, immunoblotting experiments demonstrated that AG-08 promoted cleavage of various proteins such as ATGs, p62, and PARP-1. | en_US |
| dc.identifier.doi | 10.1055/s-0039-3399943 | en_US |
| dc.identifier.issn | 0032-0943 | |
| dc.identifier.issn | 1439-0221 | |
| dc.identifier.uri | https://doi.org/10.1055/s-0039-3399943 | |
| dc.identifier.uri | https://hdl.handle.net/11147/9381 | |
| dc.language.iso | en | en_US |
| dc.publisher | Georg Thieme Verlag | en_US |
| dc.relation.ispartof | Planta Medica | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | A New Semi-Synthetic Sapogenol Derivative Inducing Regulated Necrosis | en_US |
| dc.type | Conference Object | en_US |
| dspace.entity.type | Publication | |
| gdc.author.institutional | Üner, Göklem | |
| gdc.author.institutional | Bedir, Erdal | |
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| gdc.description.department | İzmir Institute of Technology. Bioengineering | en_US |
| gdc.description.endpage | 1507 | en_US |
| gdc.description.issue | 18 | en_US |
| gdc.description.publicationcategory | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q3 | |
| gdc.description.startpage | 1507 | en_US |
| gdc.description.volume | 85 | en_US |
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