A Green Route to Albumin/Albumin Polyelectrolyte Complex Nanoparticles in Water With High Drug Loading for Drug Delivery
| dc.contributor.author | Sozer-Demirdas, Sumeyra Cigdem | |
| dc.contributor.author | Erez, Ozlem | |
| dc.contributor.author | Cakan-Akdogan, Gulcin | |
| dc.contributor.author | Akdogan, Yasar | |
| dc.date.accessioned | 2025-09-25T18:56:14Z | |
| dc.date.available | 2025-09-25T18:56:14Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | A polyelectrolyte complex (PEC) formation offers a simple and green approach to obtaining albumin nanoparticles (NPs) without the use of organic solvents, crosslinkers and specialized equipment. The prepared cationic albumin proteins interact with anionic albumin proteins to form albumin PEC NPs (110 nm) with +37 mV surface zeta potential. Furthermore, albumin PEC NPs preparation in water alone achieves chlorambucil (CHL) loading up to 17 times higher than the conventional desolvation method, largely due to the elimination of drug loss to organic solvents. CHL loaded albumin PEC NPs also decreased the cell viability (Huh-7) to 44 % within 24 h. This study demonstrates that high drug-loaded albumin NPs can be alternatively synthesized by using albumin polyelectrolyte properties, and applied in drug delivery applications. | en_US |
| dc.description.sponsorship | Izmir Institute of Technology Scientific Research Projects Coordination Unit [2022IYTE-3-0035]; Health Institutes of Turkiye (TUSEB) [2024-B-01-4001]; European Union [952346] | en_US |
| dc.description.sponsorship | This work was financially supported by the Izmir Institute of Technology Scientific Research Projects Coordination Unit via the 2022IYTE-3-0035 and Health Institutes of Turkiye (TUSEB) via 2024-B-01-4001. Ozlem Erez was funded by European Union RareBoost Project #952346. The authors thank the IZTECH Center for Materials Research, the IZTECH Biotechnology and Bioengineering Application and Research Center, the IZTECH National Mass Spectrometry Application and Research Center, the IBG Optic Imaging Core Facility, Prof. Dr. Mustafa M. Demir for DLS measurements, Yesim Yoldas for in vitro cell measurements and Ozge B. Akdogan for the graphical abstract. | en_US |
| dc.identifier.doi | 10.1016/j.ijbiomac.2025.146978 | |
| dc.identifier.issn | 0141-8130 | |
| dc.identifier.issn | 1879-0003 | |
| dc.identifier.scopus | 2-s2.0-105013212667 | |
| dc.identifier.uri | https://doi.org/10.1016/j.ijbiomac.2025.146978 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartof | International Journal of Biological Macromolecules | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Albumin Polyelectrolyte | en_US |
| dc.subject | Nanoparticle | en_US |
| dc.subject | Aqueous Media | en_US |
| dc.subject | Dug Delivery | en_US |
| dc.subject | Cell Viability | en_US |
| dc.title | A Green Route to Albumin/Albumin Polyelectrolyte Complex Nanoparticles in Water With High Drug Loading for Drug Delivery | |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.wosid | Cakan-Akdogan, Gulcin/Gro-6030-2022 | |
| gdc.coar.type | text::journal::journal article | |
| gdc.collaboration.industrial | false | |
| gdc.description.department | İzmir Institute of Technology | en_US |
| gdc.description.departmenttemp | [Sozer-Demirdas, Sumeyra Cigdem; Akdogan, Yasar] Izmir Inst Technol, Mat Sci & Engn Dept, TR-35430 Izmir, Turkiye; [Erez, Ozlem; Cakan-Akdogan, Gulcin] Izmir Biomed & Genome Ctr, TR-35340 Izmir, Turkiye; [Cakan-Akdogan, Gulcin] Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, TR-35430 Izmir, Turkiye | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.volume | 322 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.openalex | W4413276420 | |
| gdc.identifier.pmid | 40834949 | |
| gdc.identifier.wos | WOS:001564930000001 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed | |
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