Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Valorization of Recycled Waste in Green/White Purification and LC-QTOF/MS Analysis of Beverages Adulterated with Incapacitating Drugs(Elsevier B.V., 2026) Anilanmert, Beril; Yonar, Fatma Cavus; Er, Elif Ozturk; Pekcaliskan, Elif Yılmaz; Cengiz, SalihIncapacitating drugs constitute a growing threat for the community, since victims may drink adulterated beverages without noticing. A validated eco-friendly/economical purification/analysis kit prototype, along with an LC-QToF/MS method has been developed in coke and mixed fruit-juice, for simultaneous determination of 10 drugs used for incapacitating victims (zaleplone, zolpidem, zopiclone, mephedrone, fentanyl, phenytoin, thiopental, sertraline, ketamine and GHB). A combination of two different waste nut-shells which yielded the highest recovery for these drugs were directly used as adsorbent after grinding and modification and a reusable separation apparatus recycled from waste were utilized for the first time in a toxicological analysis. In the method, after adding the adsorbent on to the sample, pH was adjusted. Following 25-min (min) automatic vortexing for adsorption, matrix was removed easily, using the separation apparatus. After 25-min desorption via cold ultrasonication using 500 μL methanol, a 9.5-min LC-QToF/MS analysis was performed. The validated method in fruit-juice and coke, extraordinarily gave successful results also in urine and saliva. Assessment tools for greenness/whiteness and pictograms confirmed the environmental friendliness of the method kit. © 2025 Elsevier B.V.Article Polyaspartic Ester Polyurea-TiO2nanocomposite Coatings for UV Protection of Leading Edge of Wind Turbine Blades(Elsevier B.V., 2026) Olcer, Y.A.; Karabacak, B.D.; Demirkurt, M.; Yoldaş, İ.; Can y, Z.; Demir, M.Polyaspartic ester polyurea (PAEPU) supplies a promising matrix for high-durability coatings. However, its poor UV-A resistance make its usage limited. In this work, commercially available anatase TiO<inf>2</inf> particles (0.05–10 wt%) were dispersed in PAE matrix without any modification. PAEPU/TiO<inf>2</inf> composites were supplied by the reaction of PAE/TiO<inf>2</inf> matrix with an aliphatic isocyanate. UV–Visible spectra of spin coated PAEPU/TiO<inf>2</inf> composite thin films showed an exponential decrease in transmittance with increasing amount of TiO<inf>2.</inf> The optical response is dominated by UV blocking for TiO<inf>2</inf> amounts smaller than 0.3 wt%. For above 0.5 wt% TiO<inf>2</inf> amounts, transparency to translucency transition signifies the beginning of multiple scattering. The diameter of particles analyzed by AFM showed that particle diameter is 47 ± 11 nm taking into account of images of the PAEPU films containing 0.3 wt% of TiO<inf>2</inf> particles. Radial distribution function of the particle domains achieved from microscopy suggests that interparticle distance gets smaller than the wavelength of the incident light even at low the particle concentration. Accelerated weathering test were performed by applying 0.1, 0.5, 1.0, and 3.0 wt% TiO<inf>2</inf> containing PAEPU composite films on a white primer with Doctor Blade method. 0.1 wt% PAEPU/TiO<inf>2</inf> composites shows lower ΔE value compare to both neat and higher amounts of TiO<inf>2</inf> containing PAEPU composite films. The results suggest that without the complexity and cost of the surface modification, the low loading of commercial TiO<inf>2</inf> into PAE matrix may supply UV-stabilized PAEPU coatings relevant to the leading-edge protection of wind-turbine blades. © 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Article A Simplified Molecular Imprinting Strategy Through Electrospinning of Polyacrylonitrile for Thin Film Microextraction of Selected Pesticides(Elsevier B.V., 2026) Şahin, A.; Akpinar, Y.; Yildirim, E.; Eroǧlu, A.E.; Boyaci, E.Molecularly imprinted polymers (MIPs) have been extensively used as selective extractive phases for sample preparation because of their analyte-selective binding sites. However, MIP preparation requires optimized monomer-template interactions and long polymerization reactions. In this study, a novel and simple method of MIP preparation was proposed based on electrospinning. Instead of preparing analyte-monomer complexes before polymerization, model analytes (trifluralin and carbaryl) were directly dissolved in a polyacrylonitrile (PAN) solution, then electrospun into nanofibrous mats. This allowed for a means of preparation of highly crystalline, template-imprinted nanostructures with minimal synthetic complexity. Following the characterization studies for the new material, the extraction properties of the imprinted and nonimprinted electrospun mats were investigated in thin film microextraction (TFME) studies by extracting trifluralin and carbaryl from water samples, followed by gas chromatography-mass spectrometry (GC–MS) analysis. The optimization results showed that samplers containing 10.0 mg of MIP sorbents made by electrospinning of a solution containing 5.0 mg of template in 1.0 mL of PAN solution resulted in approximately 4 and 7 times enhanced extraction recoveries for carbaryl and trifluralin compared to samplers made of non-imprinted bulk PAN. Moreover, the cross-reactivity testing performed with non-template analytes (malathion and diazinon) suggested a more specific extraction towards trifluralin compared to carbaryl. The proposed new technique was also validated using computational methodology, which supported the experimental finding about higher selectivity towards trifluralin. This may signify a probability for structural orientation of partially charged trifluralin under an electrical field in electrospun PAN creating favorable extraction sites. © 2025 Elsevier B.V.Conference Object Microarc: Event Driven Analysis and Design Method for Microservices(Elsevier B.V., 2025) Yıldız, Ali; Demirors, OnurThe rapid development of the Internet infrastructure has enabled software applications to leverage almost unlimited and scalable resources. Microservice-based architecture has emerged as a solution to harness the benefits of a distributed cloud-based infrastructure. Event-driven architecture is a powerful approach for addressing challenges in distributed systems, such as scalability, distributed data, and sharing of data at scale. In an event-driven microservice architecture, decoupled services interact by responding to events and event streams facilitate data sharing between them. Despite these advantages, there is no de facto method for the analysis and design of systems within microservice architecture. Organizations often face difficulties in developing microservice-based systems, owing to the lack of well-defined methodologies for analysis and design. In this study, we present an analysis and design method for microservice-based systems. MicroArc is a method for analyzing and designing microservice-based systems, and comprises modeling notations, guiding processes to articulate how the method is applied, and a supporting tool for modelling. The MicroArc approach enables the identification of events and microservice candidates by modeling the flow of processes in the early phase of development. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 3Citation - Scopus: 1Porous Polymer-Derived Ceramics for Environmental Applications: Sorption, Filtration, and Catalysis(Elsevier B.V., 2025) Icin, Oyku; Zeydanli, Damla; Biesuz, Mattia; Soraru, Gian Domenico; Vakifahmetoglu, CekdarPolymer-derived ceramics (PDCs), obtained from preceramic polymers, have emerged as promising materials for environmental applications due to their high thermal and chemical stability, tunable nano-microstrucure and porosity, and versatile surface functionalities. This review focuses on the recent advances in porous PDCs and their use in key environmental fields such as sorption, filtration, and catalysis. A comparative analysis of precursor chemistry, synthesis strategies, and resulting structural properties is presented, emphasizing how these factors influence performance in environmental remediation tasks. By consolidating findings across specific application areas, the work aims to clarify the functional potential of PDCs and identify current research gaps and opportunities for future development in environmental material science.Article Citation - WoS: 2Citation - Scopus: 2A Comprehensive Study on the Effectiveness of the Stress and Damage Model Parameters in Predicting the Compression Fracture Behavior of Selective Laser Melted AlSi10Mg BCC Lattices(Elsevier B.V., 2025) Guden, Mustafa; Erten, Hacer Irem; Gorguluarslan, Recep M.; Gulletutan, Umut Can; Dagkolu, Akin; Gokdag, Istemihan; Namazov, SubhanThe Johnson and Cook (JC) stress and damage model parameters determined from the machined bulk cylindrical specimens and as-built struts through tension and compression tests were used to model quasi-static compression behavior of selective laser melt-fabricated AlSi10Mg alloy lattices. The lattices had the same cell size (10 mm) and strut diameter (1 mm), but different number of cells (2 x 2 x 2, 10 x 10 x 2 and 5 x 5 x 5) and geometries (sandwich and cubic). Four different sets of JC damage model parameters (brittle and ductile notch-insensitive and compression and tension notch-sensitive) were further implemented in the lattice compression numerical models. The brittle damage model parameters and smaller mesh sizes resulted in cracking the face-sheet corner strut nodes before the occurrence of a bending-dominated initial peak stress. The notch-sensitive damage model parameters exhibited no bent-strut fracture in the middle layers of the lattices and increased the crack initiation strains as compared with the notch-insensitive damage model parameters. Despite significant variations in the initial peak stresses of the tested 2 x 2 x 2 and 10 x 10 x 2 lattices, the implication of the strut micro-tension stress model together with the compression notch-sensitive damage model parameters using 0.25 mm mesh size conservatively approximated the experimental deformation stresses while the machined bulk specimen tensionstress model over predicted the experimental stresses. On the other side, the strut stress model with 0.15 mm mesh size accurately predicted the experimental diagonal shear/fracture mode of struts with a slightly higher numerical initial peak stress. The compression tests on the strut specimens extracted from the as-built lattices yielded similar stress model parameters with the micro-tension tests. The differences between the initial peak stresses of the investigated sandwich and cubic lattices were further explained by the differences in the lattice boundary conditions.Article Recent Developments in the Treatment of Leishmaniasis: Natural Compounds, Drug Targets, in Silico Molecular Docking Approaches, and Nanocarriers(Elsevier B.V., 2025) Gürbüz Çolak, N.Leishmaniasis is a common tropical disease caused by Leishmania protozoa. It affects 0.9 to 1.6 million people, causing 20,000–30,000 deaths annually. There are no effective vaccines, and current treatments have severe side effects. Drug resistance is a major obstacle in treating leishmaniasis. The necessity of drug discovery is indisputable. Natural compounds are promising candidates for drug discovery studies because of their diverse chemical structures and bioactivities. Experimental screening of compound libraries imposes high costs and is time-consuming. The molecular docking approach is beneficial for exploring new therapeutics in silico as it allows the screening of millions of drug candidates. Even if new drug candidates are discovered, delivery of the active ingredient to the target remains controversial. Nanocarriers are promising nanosystems that can address the drawbacks of drug delivery. This chapter focuses on natural compounds as drug candidates, targets, in silico drug discovery, and drug delivery for the treatment of leishmaniasis. © 2025 Elsevier Inc.Article Citation - WoS: 4Citation - Scopus: 4Novel Electrospun-Based Extractive Probes for Rapid Determination of Clinically Important Compounds in Human Plasma(Elsevier B.V., 2024) Temel,E.R.; Eroğlu,A.E.; Salih,B.; Boyaci,E.Background: Coated blade spray (CBS) represents an innovative approach that utilizes solid-phase microextraction principles for sampling and sample preparation. When combined with ambient mass spectrometry (MS), it can also serve as an electrospray ionization source. Therefore, it became a promising tool in analytical applications as it can significantly reduce the analysis time. However, the current CBS coatings are based on the immobilization of extractive particles in bulk polymeric glue, which constrains the diffusion of the analytes to reach the extractive phase; therefore, the full reward of the system cannot be taken at pre-equilibrium. This has sparked the notion of developing new CBS probes that exhibit enhanced kinetics. Results: With this aim, to generate a new extractive phase with improved extraction kinetics, poly(divinylbenzene) (PDVB) nanoparticles were synthesized by mini-emulsion polymerization and then immobilized into sub-micrometer (in diameter) sized polyacrylonitrile fibers which were obtained by electrospinning method. Following the optimization and characterization studies, the electrospun-coated blades were used to determine cholesterol, testosterone, and progesterone in plasma spots using the CBS-MS approach. For testosterone and progesterone, 10 ng mL−1 limits of quantification could be obtained, which was 200 ng mL−1 for cholesterol in spot-sized samples without including any pre-treatment steps to samples prior to extraction. Significance: The comparison of the initial kinetics for dip-coated and electrospun-coated CBS probes proved that the electrospinning process could enhance the extraction kinetics; therefore, it can be used for more sensitive analyses. The total analysis time with this method, from sample preparation to instrumental analysis, takes only 7 min, which suggests that the new probes are promising for fast diagnostic applications. © 2024 Elsevier B.V.Article Citation - WoS: 8Citation - Scopus: 7Delignification of Corncob by Choline Chloride-Urea Deep Eutectic Solvent for Enzymatic Production of Xylooligosaccharides(Elsevier B.V., 2024) Yanak,S.; Buyukkileci,A.O.Deep eutectic solvent (DES) pretreatment was applied to corncob to obtain xylooligosaccharides (XOS) by enzymatic hydrolysis using xylanase. Based on the XOS titers in the hydrolysate, urea was the most effective among the hydrogen bond donors tested to couple choline chloride (ChCl). DES pretreatment at 130 °C for two hours with ChCl-Urea (molar ratio of 1:2) containing 40 % water, decreased lignin fraction from 12.8 % to 6.9 %, while 79 % of the xylan was retained in the pretreated corncob. The highest XOS production was obtained using 400 U/g xylanase at 60 °C, which yielded 12.0 g/L XOS with a low degree of polymerization (LDP-XOS). The total XOS yield based on the raw corncob was calculated as 14.4 %, 90 % of which was LDP-XOS. The cellulose-rich residual biomass could be hydrolyzed enzymatically to glucose with 65 % cellulose digestibility. The discarded biomass after hydrolyzes was 21.7 % of the raw material. The results showed that DES was a promising pretreatment for enhancing enzymatic XOS production. © 2024 Elsevier B.V.Article Citation - WoS: 13Citation - Scopus: 12Dunaliella Salina Microalgae Aqueous Extract-Based Magnetic Nanoparticles (fe3o4-Nps): Green Synthesis, Characterization and in Vitro Anticancer Investigations(Elsevier B.V., 2024) Jafari,N.; Hamishehkar,H.; Mohammadpourfard,M.In the current study, a facile, rapid, and eco-friendly method was provided for green synthesizing of magnetic Fe3O4-NPs with enhanced stability and biocompatibility using different weight concentrations (1 %, 3 %, and 5 %) of aqueous extract of Dunaliella salina (D. salina) microalgae. The properties of the green-synthesized magnetic nanoparticles (GMNPs-ex1%, GMNPs-ex3%, and GMNPs-ex5%) were compared with chemically-synthesized ones (CMNPs) via XRD, TEM, FESEM, VSM, DLS, ZP, FTIR, hemolysis, cell viability, DAPI staining, and apoptosis analyses. TEM imaging revealed mean sizes of 11.21 ± 2.63 nm and 14.08 ± 3.24 nm for GMNPs-ex5% and CMNPs, respectively, with better dispersity for GMNPs-ex5%, as confirmed with their polydispersity index (PDI = 0.24 for GMNPs-ex5% and 0.58 for CMNPs). These sizes were consistent with the crystallite size of pure magnetite phase nanoparticles obtained from XRD. FESEM images confirmed spherical shape for the majority of nanoparticles. FTIR spectra confirmed the involvement of functional groups from the extract in GMNPs, contributing to their stability (ZP of GMNPs-ex5% = −34 mV). The saturation magnetization decreased with increasing the extract ratio (from 62.41 to 8.94 emu/g), attributed to the non-magnetic nature of the extract coating. GMNPs-ex5% exhibited a negligible hemolysis rate (< 2 %) compared to CMNPs. Furthermore, IC50 values of GMNPs and extract against HFF-2 and A549 cells were higher than those of CMNPs, indicating the biocompatibility of green-synthesized nanoparticles. In the DAPI staining method, GMNPs-ex5%, similar to the extract, caused less DNA damage to HFF-2 cells. Additionally, the apoptosis assay using annexin V/PI staining kit indicated that green-synthesized nanoparticles induced lower apoptosis in normal cells. Overall, this study highlights the potential of green-synthesized Fe3O4-NPs for various biomedical applications, showcasing their enhanced properties and biocompatibility compared to conventionally synthesized counterparts. © 2024 Elsevier B.V.
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