Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article The Effects of Lactobacillus and/or Bifidobacterium in Fermented Foods on Cognitive Health: A Systematic Review(Frontiers Media SA, 2025) Harsa, Hayriye Şebnem; Gonzalez Domenech, Carmen Maria; Prvulovic, Milica; Agirbasli, Zeynep; Bagherzadehsurbagh, Erfan; Simeunovic, Valentina; Pracer, Smilja; 03.08. Department of Food Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyBackground: Psychobiotics are microorganisms that modulate brain function via the gut-brain axis and are increasingly studied for their cognitive benefits. Lactobacillus and Bifidobacterium species, widely present in fermented foods, are considered safe and may influence cognition by modulating neuroinflammation, neurotransmitters, and gut barrier integrity. This systematic review examined the effects of foods fermented with these species on cognitive performance in healthy adults and individuals with mild cognitive impairment. Methods: We conducted the systematic review following EFSA guidelines, Cochrane methodology, and a PROSPERO protocol, using CADIMA for study selection and data extraction. PubMed, Scopus, and Cochrane Library were searched (1 January 1970-31 August 2023) for human intervention and observational studies assessing cognitive outcomes after ingestion of foods fermented with Lactobacillus or Bifidobacterium. Eligible populations included healthy adults and individuals with mild cognitive impairment; studies involving disease were excluded. Screening, data extraction, and bias assessment followed Muka et al.'s 24-step guide using ROBINS and Cochrane/CADIMA frameworks. Evidence was synthesized narratively, while a non-systematic component examined food characteristics, potential mechanisms, and factors affecting bioavailability of bioactive constituents. Results: We included 21 studies (8 interventional, 13 observational). The majority of studies reported benefits, particularly in episodic memory, executive functions, and global cognition, but evidence was limited by inadequate controls, small sample sizes, short interventions, inconsistent domain assessment, and incomplete food characterization. Observational studies had larger populations and longer follow-ups but were limited by exposure assessment and depth of cognitive testing. Conclusion: Consumption of foods fermented with Lactobacillus and/or Bifidobacterium species may offer promising cognitive benefits. However, following EFSA's guidance on the substantiation of health claims, the current evidence is "neither convincing nor sufficient" to establish a causal relationship. Well-designed studies with thorough product characterization are needed to substantiate effects and support potential health claims.Review Citation - Scopus: 1Effect of Probiotics and Prebiotics on Gut-Brain Axis;(Sidas Medya A.S., 2019) Harsa, Hayriye Şebnem; Özyurt,G.; Harsa,Ş.T.; 01. Izmir Institute of Technology; 03.08. Department of Food Engineering; 03. Faculty of EngineeringPeople have been started to consume functional foods that promote health with changing nutritional dynamics all over the world. Psychological signs such as level of daily stress and emotional changes affect the microbiota negatively. Neuropsychiatric disorders cause irregular release of neurotransmitters like gamma-aminobutyric acid; therefore, functional food ingredients can be used as therapeutic agents. The purpose of this study is to review the positive impacts of prebiotics, and probiotics, and functional foods containing these ingredients on the gut-brain axis through the health of microbiota. The definition of probiotics and prebiotics and their neurotransmitters secreted, the effects on neuropsychological health, the role of intestinal metabolic disorders in the formation of neuropsychiatric diseases, the importance of gut-brain axis on this mechanism are presented in the light of scientific researches and current literature. In this study, the contribution of food biosciences into this interdisciplinary area is highlighted. © 2019 Authors. All rights reserved.