Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 6Citation - Scopus: 6A Novel 2-Aminophenalenone Fluorescent Probe Designed for Monitoring H2o2 for in Vitro and in Vivo Bioimaging(Elsevier, 2024) Saygılı, Ecem; Ersöz Gülseven, Esra; Kıbrıs, Erman; Çakan Akdoğan, Gülçin; Üçüncü, MuhammedA significant compound in living organisms, hydrogen peroxide (H2O2) plays a dual role as a signalling molecule in cellular communication and as a pivotal biomarker in assessing disease and oxidative stress. Thus, the detection of abnormal changes in H2O2 levels is essential to understanding its function and involvement in biological systems. The growing demand to meet the specific needs for applications, particularly in biological systems, has sharpened focus on highly sensitive, highly selective molecular sensors and, in turn, heightened interest in these diagnostic tools with innovative designs. In our study, 2-aminophenalenone (2-AP) was used for the first time as a fluorophore in a fluorescent probe. The 2-APB molecule obtained from the reaction of 2-AP with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzyl chloroformate exhibited a highly selective and sensitive (i.e. 62 nM) detection profile for H2O2 compared with the other reactive oxygen species, anions, and metal cations. Moreover, offering naked-eye detection in aqueous solutions, 2-APB demonstrated excellent sensing performance, detection and real-time monitoring in relation to exogenous H2O2 in cells and endogenous H2O2 in zebrafish embryos. © 2024 Elsevier B.V.Article Citation - WoS: 51Citation - Scopus: 53Bodipy-Au(i): a Photosensitizer for Singlet Oxygen Generation and Photodynamic Therapy(American Chemical Society, 2017) Üçüncü, Muhammed; Karakuş, Erman; Kurulgan Demirci, Eylem; Sayar, Melike; Dartar, Suay; Emrullahoğlu, MustafaUpon complexation with Au(I), a photoinactive BODIPY derivative was transformed into a highly photoactive triplet sensitizer. Along with high efficiency in singlet oxygen generation (φδ = 0.84), the new BODIPY-Au(I) skeleton showed excellent photocytotoxic activity against cancer cell lines (EC50 = 2.5 nM).Article Citation - WoS: 80Citation - Scopus: 82Electrophilic Cyanate as a Recognition Motif for Reactive Sulfur Species: Selective Fluorescence Detection of H2s(American Chemical Society, 2016) Karakuş, Erman; Üçüncü, Muhammed; Emrullahoğlu, MustafaAn ESIPT-based fluorescent dye, 3-hydroxyflavone, is chemically masked with an electrophilic cyanate motif in order to construct a fluorescent probe for cellular sulfur species. This novel probe structure, displays an extremely fast, highly sensitive and selective "turn-on" type fluorescent response toward H2S. We have also documented its utility for imaging of H2S in the living cells.Article Citation - WoS: 22Citation - Scopus: 24A Fluorescein-Based Chemodosimeter for Selective Gold(iii) Ion Monitoring in Aqueous Media and Living Systems(Elsevier Ltd., 2016) Çetintaş, Ceyla; Karakuş, Erman; Üçüncü, Muhammed; Emrullahoğlu, MustafaWe constructed a turn-on type chemodosimeter based upon a fluorescein scaffold for the rapid, selective detection of gold(III) ions over other metal species. This novel probe structure offers distinct features including high water solubility, a low detection limit, rapid response time and applicability in imaging gold(III) ions in living cells.Article Citation - WoS: 43Citation - Scopus: 43A Bodipy-Based Fluorescent Probe for the Differential Recognition of Hg(ii) and Au(iii) Ions(Royal Society of Chemistry, 2015) Cantürk, Ceren; Üçüncü, Muhammed; Emrullahoğlu, MustafaWe describe the design, synthesis and spectral behaviour of a fluorescent molecular sensor able to recognize Hg2+ and Au3+ ions via different emission modes. The molecular sensor is constructed on a single BODIPY dye appended with a semithio-carbazone functionality as a recognition motif.Article Citation - WoS: 37Citation - Scopus: 38Palladium-Catalyzed Alkoxycarbonylation of (z)-2 Carbonates Leading To 2,3,5-Trienoates(American Chemical Society, 2011) Akpınar, G. Eray; Kuş, Melih; Üçüncü, Muhammed; Karakuş, Erman; Artok, LeventPd(0)-catalyzed carbonylation of (Z)-2-en-4-yn carbonates in the presence of a balloon pressure of CO in an alcohol donates vinylallenyl esters with an exclusively E-configuration and in high yields. The fact that no such reactivity could be observed with E-configured enyne carbonates may indicate that the reaction is promoted via the cooperative coordination of palladium with both alkynyl and carbonate moieties.