Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Byzantine Wall Paintings in the Archaeological Sites of Aigai, Olympos, and Anaia (Turkey): Techniques and Material Characteristics(Routledge Journals, Taylor & Francis Ltd, 2025) Şerifaki, K.; Böke, H.The aim of this study is to determine the material characteristics of the paint layers and techniques of paintings executed in Late Roman and Byzantine churches located in the archaeological sites of Aigai, Olympos, and Anaia (Turkey) in order to select compatible materials prior to conservation treatments of the paintings and to establish the technical aspects of the paintings in relation to coeval Western examples. In this context, the execution technique, microchemical characteristics, stratigraphy of paintings, and mineralogical and chemical composition of the pigments were determined by polarized light microscopy (PLM), scanning electron microscopy coupled with X-ray energy dispersive spectroscopy (SEM-EDX), and Fourier transform infrared spectroscopy (FTIR). The analysis results indicated that wall paintings were executed by fresco, secco or fresco-secco techniques on a thin plaster layer that is composed of pure lime, straw, fine marble, brick, and sand aggregates. The ground layers of the paintings are composed of kaolin, calcite, and carbon black. The color compositions of the paintings were obtained by applying successive layers of paint on the ground layers. The pigments used in the paintings are mainly iron oxides for the red and yellow, green earth in celadonite and glauconite forms for greens, and lapis lazuli and Egyptian blue for blues. The present study demonstrates that the techniques and materials employed in the execution of wall paintings in Byzantine churches in Western Anatolia are analogous to those utilized in the Balkans, Crete, and Cyprus, with the exception of the presence of a clay-based ground. © The International Institute for Conservation of Historic and Artistic Works 2025.Article Citation - WoS: 1Citation - Scopus: 1Microporous Carbon Spheres for the Enrichment of Lead From Water Samples With Determination by Microsample Injection System - Flame Atomic Absorption Spectrometry (MIS-FAAS)(Taylor & Francis inc, 2025) Njjar, Muath; Ugan, Muhammet; Akturk, Ezgi Zekiye; Pelech, Iwona; Staciwa, Piotr; Akdogan, AbdullahMicroporous carbon spheres (MCSs) are advanced materials known for their high surface area, well-developed pore structure, low density, and rapid molecular diffusion, making them highly effective in solid-phase extraction (SPE) and other applications. In this study, MCSs synthesized from previously reported resorcinol-formaldehyde resin were employed as an adsorbent for the extraction and preconcentration of Pb(II) ions. The material was comprehensively characterized to confirm its suitability for adsorption applications. The adsorption and desorption behavior of MCSs toward lead ions was systematically examined under optimized conditions, including pH, eluent volume, eluent type, eluent concentration, and sample volume. Microinjection microsample injection system-flame atomic absorption spectrometry (MIS-FAAS) was used for the determination of lead ions. Experimental results from batch experiments showed that the MCSs exhibited a maximum adsorption capacity of 37.31 mg g-1. Under optimal conditions (pH 8.0, 1.0 mL of 0.1 M HNO3 eluent, and 10 mg of adsorbent), a preconcentration factor of 100 was achieved, with recovery values exceeding 90%. The method exhibited a limit of detection (LOD) of 0.73 mu g L-1. The developed method was successfully applied to real water samples, including tap water, entering industrial wastewater, and exiting industrial wastewater, confirming its potential for use in environmental monitoring and contamination control.Editorial Editorial: Advancing Biotechnology in Turkiye: a Dedication To All Women(Springer, 2025) Cadirci, Bilge Hilal; Buyukkileci, Ali Oguz; Binay, BarisArticle Review of the Relationship Between Growth Hormone and SARS-CoV-2 Infection(Taylor & Francis Ltd, 2025) Rasmi, Yousef; Kirboga, Kevser Kubra; Roshanravan, Neda; Tekin, Burcu; Jalali, Ladan; Ghazizadeh, FaridRecent evidence suggests that SARS-CoV-2 is associated with the endocrine system, particularly growth hormone (GH). GH modifies immune responses and its deficiency could be responsible for the uncontrolled immunity that occurs in severe cases of COVID-19. Recent research shows that patients suffering from lung complications have significantly lower levels of GH and insulin-like growth factor-1 (IGF-1), which are proportionate to the severity of the disease. This relationship supports the hypothesis that GH regulates the immunity and inflammatory processes of the SARS-CoV-2 virus. However, variables such as age, gender, and comorbidities, such as diabetes and obesity, which are associated with lower GH levels, are strong predictors of COVID-19 outcomes. Older individuals and men, who tend to have lower GH levels, are disproportionately represented among severely ill patients. The available evidence suggests that GH supplementation therapy should be evaluated as a supportive measure to reduce the severity of the disease in high-risk individuals. The main goal of the research is to understand how COVID-19 is related to GH so that researchers can identify new mechanisms of pathology and develop better solutions for patients.Article Poly(Ethylene Glycol)-Keratin Hydrogels Prepared Via Thiol-Maleimide Reaction(Polymer Soc Korea, 2025) Yalcin, Damla; Top, AybenThe mechanical properties of hydrogels have a profound effect on cellular responses in tissue engineering applications. In this study, poly(ethylene glycol)-keratin (PEG-KRTN) hydrogels with tunable mechanical properties were prepared by varying molar mass of the maleimide functionalized PEG in the thiol-maleimide chemistry. Reduced keratins were reacted with PEG-maleimides having 2000 Da and 6000 Da molar masses. Viscoelastic and physiochemical properties and cytocompatibility of these hydrogels were tested. Storage modulus values were obtained as 2613 +/- 254 Pa and 1313 +/- 345 Pa for PEG2000-KRTN and PEG6000-KRTN hydrogels, respectively. Strain sweep data indicate that the linear viscoelastic region (LVER) of the PEG6000-KRTN hydrogel spans up to 40% strain value, whereas it is limited to 10% critical strain for the PEG2000-KRTN hydrogel. PEG6000-KRTN hydrogel presented higher swelling ratios and porosity. CCK-8 test showed that both hydrogels promoted the proliferation of L929 mouse fibroblast cells and, hence, can be applied in soft tissue engineering.Article A Novel Approach by Combining Fuzzy Ahp and a Simulation Model To Analyze Suitability of Ports for Offshore Wind Farms(int Soc offshore Polar Engineers, 2025) Ozturk, Samet; Karipoglu, Fatih; Efe, BurakThis study presents a comprehensive suitability analysis for assessing the serviceability of existing container ports for offshore wind farms (OWFs) in Turkey, utilizing a combination of fuzzy analytical hierarchy process with Arena simulation modeling. This study is the first comprehensive analysis of offshore wind port infrastructure that integrates a multi-criteria decision making process with an Arena simulation model tailored specifically for existing container ports. The results indicate that technical criteria are deemed most critical, carrying the highest weight (0.563), with expansion potential identified as the most impactful criterion within the technical category. In addition, the study employs the Arena simulation software to forecast the operational workload on the most suitable ports following potential OWF installations.Article Investigation of the Effect of Solar Energy Use in Buildings on Reducing Carbon Dioxide Emissions(Inderscience Enterprises Ltd, 2025) Hancioglu, EbruThe aim of this study was to examine the reduction in CO2 emissions by using solar modules. In the article, the energy analysis of Narldere Nursing Home and Rehabilitation Centre (NNHRM) an exemplary public building in Izmir, was discussed. In this study, it was determined that if 1,500 kWp PV Panels were used, approximately 63.58% of the facility's electricity needs would be met by PV panels. It was revealed that by using the use of PV panels, an improvement of 6.98% in primary energy, 12.27% in CO2 emissions and 7.51% in PER would be achieved. The repayment period is calculated as 7.1 years.Article Cx32 Cellular Localization Is Related To Epithelial To Mesenchymal Transition in Breast Cells(Pleiades Publishing inc, 2025) Oz, Sercan; Turan, Fatma Basak; Yondem, Eyup; Pesen-Okvur, Devrim; Yalcin-Ozuysal, Ozden; Ozcivici, Engin; Mese, GulistanConnexins (Cx) play both gap junction-related and -independent roles in cells, and their localization is essential for their function in cellular processes. Besides membrane localization, connexins can also be localized to the cytoplasm and nucleus, especially in cancer cells. The differential localization of connexins including Cx32 was observed in different stages of cancers. Cx32 was upregulated and observed in cytoplasms of cells in lymph-node metastasis of breast cancer samples compared to primary tumors. However, the significance of the increase in Cx32 expression and alteration of Cx32 cellular localization in epithelial-to-mesenchymal transition (EMT) is not known. To determine if Cx32 overexpression and/or localization over one week would induce the EMT process, we first examined the cellular localization of Cx32 in MCF10A and MDA-MB-231 cells at different time points using Western blot and RT-PCR as well as immunostaining with confocal microscopy. Then, we correlated the changes of Cx32 expression and localization with EMT marker expression. We showed that Cx32 had altered cellular localization and Cx32 overexpression increased Slug levels while it reduced E-cadherin and Snail expression in MDA-MB-231 for 7 days. In contrast, E-cadherin and Vimentin were reduced in MCF10A-Cx32 cells compared with controls over 7 days, and the expression pattern for nuclear Cx32 and Zeb2 was following similar pattern in MCF10A cells. Our results suggest a previously unknown time-dependent relation between Cx32 and the regulation of the EMT process.Article Is It Still Important Centrality?: Locational Preferences of the Software Industry in Istanbul(Routledge, 2024) Köse, Ş.; Lale Berköz, A.The software industry is one of the main driver sectors in the development of contemporary cities. The aim of this article is to analyze the location behaviors of the software industry in Istanbul with a hybrid model by determining the locations and the main factors that are effective in the location preference. Within the scope of the study, focus group interviews were conducted with 6 members of the Software Industrialists Association and a survey was conducted with 177 firm officials and the results were examined through Average Nearest Neighbor, Quartic Kernel Density, Spatial Autoregressive Model and Spatial Error Model. The findings showed that centrality is still important for the firms and most of them benefit from urban agglomeration. While the firms are clustered in the CBD and sub-centers, we have concluded that the spatial behavior patterns of the firms have also changed according to their capital size. Urban agglomeration explains the local-scale software industry in the literature but does not provide sufficient arguments to analyze it on a global scale. However, it is foreseen that the findings may vary in a particular way if the firms are examined by separating according to production manner. © 2025 ETH–Eidenössiche Technische Hochschule Zürich.Article The Effectiveness of Genetic Markers and the Role of Environmental Factors in Hip Dysplasia and Osteochondritis Dissecans of the Shoulder in German Shepherd, Labrador Retriever, and German Wirehaired Pointer (Deutsch Drahthaar) Dogs(Elsevier, 2025) Ardicli, Sena; Yigitgor, Pelin; Ozen, Dogukan; Babayev, Huseyn; Bozkurt, Berkay; Senturk, Nursen; Intas, Deniz SeyrekCanine Hip Dysplasia (CHD) is the most frequently diagnosed orthopedic condition in dogs. Similar to CHD, osteochondritis dissecans (OCD) of the shoulder is a developmental disorder in dogs that significantly impacts animal welfare. As polygenic genetic disorders, they exhibit a complex mode of inheritance. Although there are numerous clinical studies, there is insufficient information about the genetic basis of these disorders. Therefore, this study aimed to assess the relationship of the prognostic genetic test markers with CHD and OCD in German Shepherd, Labrador Retriever, and German Wirehaired Pointer dogs. We evaluated the efficiency of five SNP markers from the prognostic genetic test for CHD (the Dysgen test) based on available GWAS data in German Shepherd, Labrador Retriever, and German Wirehaired Pointer dogs. Radiographs were captured and assessed according to the official FCI scale for hip dysplasia. In German Wirehaired Pointers, shoulder X-ray evaluations were also performed. We used custom FRET-based primer probes in Real-time PCR and Sanger sequencing for genotyping and tested the evaluation using multiple logistic regression procedures. German shepherds emerged as the most vulnerable to CHD (P < 0.001). In the final logistic model, females are expected to have a 3.54 times higher likelihood of experiencing CHD compared to males (P < 0.05). SNP BICF2G630558239 demonstrated a notable association with CHD, indicating that the GG genotype poses a risk. This SNP is situated in the intronic region of the KIF26B gene, a member of the kinesin superfamily implicated in evolutionarily conserved roles in embryogenesis. We did not observe any association between shoulder OCD-related arthrosis and the SNPs studied. These results may contribute to understanding CHD by identifying genotypes associated with epidemiological risk, prompting the need to conduct more thorough investigations.