Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 10Citation - Scopus: 11Intersection of Microrna and Gene Regulatory Networks and Their Implication in Cancer(Bentham Science Publishers B.V., 2014) Yousef, Malik; Trinh, Hung V.; Allmer, JensMicroRNAs (miRNAs) have attracted heightened attention for their role as post-transcriptional regulators of gene expression. It has become clear that miRNAs can both up- and downregulate protein expression. According to current estimates, most human genes are harboring miRNAs and/or are regulated by them. Thus miRNAs form a complex network of expression regulation which tightly interacts with known gene regulatory networks. Similar to some transcription factors, some miRNAs can have hundreds of target transcripts whose expression they modulate. Thus miRNAs can form complex regulatory networks by themselves, but because their expression is often tightly coordinated with gene expression, they form an intertwined regulatory network with many possible interactions among gene and miRNA regulatory pathways. In this review we first consider gene regulatory networks. Then we discuss microRNAs and their implication in cancer and how they may form regulatory networks. Finally, we give our perspective and provide an outlook including the aspect of personalized medicine.Article Citation - WoS: 6Citation - Scopus: 9Reconstruction of Archaeological Sites: Principles Practice and Evaluation(Taylor and Francis Ltd., 2012) Yaka Çetin, Funda; İpekoğlu, Başak; Laroche, DidierThe reconstruction works at archaeological sites need to be approached with caution to prevent disturbing any surviving evidence. This study aims to develop criteria for the evaluation of reconstructions at archaeological sites. The criteria have been developed through review of current international and national conservation charters to help improve reconstruction proposals. These criteria are determined considering the remain scale and the site scale. Accuracy of the reconstruction, avoidance of physical damage, compatibility of materials, distinguishability of the interventions, availability of the interventions for future applications, and reversibility are the criteria concerning the remain scale; limits of the intervention, retainability of the original characteristics of the site, and perception of the reconstruction are the criteria concerning the site scale. These criteria are applied to the reconstruction works realized at the West Stoa of Agora, zmir, Turkey during 1930s, which had to be dismissed and reimplemented in 2000s. The recent reconstruction was applied with compatible materials; the interventions did not damage the original materials and they are distinguishable. This study of the reconstruction presents the latest architectural information, provides a basis for future studies, and is reversible. The reconstructed structure does not falsify the original characteristics, but enables increased perception of the site.Article Citation - WoS: 6Citation - Scopus: 7Reconstruction of Nonstationary Signals Along the Wavelet Ridges(World Scientific Publishing Co. Pte Ltd, 2006) Özkurt, Nalan; Savacı, Ferit AcarIn this paper, the nonstationary signals have been recovered using the skeleton along the wavelet ridges in the noisy case and the attractors of the cleaned signals are reconstructed in the phase space by time-delay embedding. In order to verify the signal recovery and reconstruction procedure, the similarity measure Hausdorff distance between cleaned, noise-free original attractors have been calculated. The computations show that the procedure reduces the noise level acceptably and the reconstructed attractors are more similar to the original attractors.