Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Advances in Optical Biosensors: Technologies and Trends in Point of Care Applications(Academic Press Inc., 2025) Sözmen, A.B.; Bayraktar, A.E.; Ülker, Ö.; Arslan-Yildiz, A.A sensor detects changes in its environment and converts them into readable data using three key components: a receptor to sense changes, a transducer to generate a signal, and a detection system to output the signal. Optical sensors are devices that use a receptor and optical transducer to produce signals corresponding to an analyte, and optical biosensors combine a biological sensing element with an optical transducer to detect and quantify specific analytes. They offer easy-to-read, real-time signals, such as color changes or light emission, sometimes even detectable by the naked eye, reducing the need for external devices and providing versatile Point-of-Care (PoC) applicability. Their portability and rapid response time enable remote testing and monitoring, further improving accessibility. They allow sensitive and selective detection of various analytes, making them utile in areas like glucose monitoring, drug testing, and pathogen detection. Many of these sensors provide label-free and non-invasive detection, further enhancing patient comfort and safety. This chapter provides an overview of optical biosensors; it starts with categorizing them by biorecognition elements, transducers, and detection modes. It investigates biosensors that utilize nanomaterials, polymers, and engineered biorecognition elements are discussed, with examples from literature. Technologies such as miniaturization, multiplexing, and wearable designs, which enhance PoC feasibility, are also examined. Lastly, challenges in development and operation are addressed, and future research directions for advancing optical biosensors in PoC diagnostics are discussed. © 2025Article Citation - WoS: 17Citation - Scopus: 21Utilization of Stalk Waste Separated During Processing of Sun-Dried Figs (ficus Carica) as a Source of Pectin: Extraction and Determination of Molecular and Functional Properties(Academic Press Inc., 2022) Çavdaroğlu, Elif; Yemenicioğlu, AhmetThis study aimed the utilization of fig stalk waste as an alternative pectin source. For this purpose, the characteristics of extracted stalk waste pectin (SP) were compared with those of citrus pectin (CP) and pectin extracted from defected substandard whole sun-dried figs (FP). The SP had a higher extraction yield (11.7%) than FP (9.4%). The galacturonic acid content and degree of esterification of SP (32.3 and 50.1%) were higher than those of FP (19.9 and 38.8%), but lower than those of CP (79.3 and 56.2%), respectively. The SP and CP had different sugar compositions (D-glucose, L-rhamnose, D-galactose and L-arabinose) and weight average molecular weights, but similar FTIR profiles. The SP showed almost 1.9 and 1.6-fold higher Trolox equivalent antioxidant capacity (TEAC), and 2.7 and 2.0-fold higher water absorption capacity than CP and FP, respectively. SP at 3% (w/w) showed the second highest viscosity after CP and the highest emulsion stability. Gels of SP and CP at 1.75–3% range had similar firmness, but SP formed more fracturable gels than CP. Sun-dried fig stalk waste is a better source of pectin than defected substandard whole sun-dried figs. The SP could be utilized to develop functional food with alternative textural and rheological properties.Article Citation - WoS: 5Citation - Scopus: 9Antilisterial Effects of Lysozyme-Nisin Combination at Temperature and Ph Ranges Optimal for Lysozyme Activity: Test of Key Findings To Inactivate Listeria in Raw Milk(Academic Press Inc., 2021) Sözbilen, Gözde Seval; Yemenicioğlu, AhmetThis study aimed to determine antilisterial potential of lysozyme (LYS)-nisin (NIS) combination at temperatures and pHs optimal for LYS activity. Tests in buffers at pH 4.5 and 6.0 showed that heating at 50 or 60 °C combined with LYS-NIS caused higher Listeria innocua inactivation (- 6.2 to >6.6 log) than heating alone (- 0.05 to 5.5 log), or heating combined with LYS (- 4.34 to 6.0 log) or NIS (3.9 to >6.6). The antimicrobial performance of LYS-NIS in buffer at 50 °C was not pH-dependant (5.8–5.9 logs) while heating at 60 °C with LYS-NIS at pH 6.0 (>6.6 logs) caused higher Listeria reduction than that at pH 4.5 (5.7 logs). Heating at 50 °C for 45 min alone or in combination with LYS-NIS caused 0 and 5.5 logs Listeria reduction in milk, respectively. In contrast, Listeria inactivation in milk at 60 °C occurred mainly by heat (5.5 logs) with limited contribution of LYS and/or NIS. Milk heated at 50 °C maintained 73% of NIS and 63% of LYS activity. Application of LYS-NIS at 50 °C provides an opportunity to improve milk safety with less destruction of milk enzyme and microbial flora necessary to obtain desired ripening periods, and aroma and flavour in traditional cheeses. © 2020 Elsevier LtdArticle Citation - WoS: 3Citation - Scopus: 3Reconstruction of Generalized Impedance Functions for 3d Acoustic Scattering(Academic Press Inc., 2019) Ivanyshyn Yaman, OlhaWe consider the inverse obstacle scattering problem of determining both of the surface impedance functions from far field measurements for a few incident plane waves at a fixed frequency. The reconstruction algorithm we propose is based on an iteratively regularized Newton-type method and nonlinear integral equations. The mathematical foundation of the method is presented and the feasibility is illustrated by numerical examples. (C) 2019 Elsevier Inc. All rights reserved.Article Citation - WoS: 26Citation - Scopus: 26Multi-Route - Multi-Pathway Exposure To Trihalomethanes and Associated Cumulative Health Risks With Response and Dose Addition(Academic Press Inc., 2019) Genişoğlu, Mesut; Ergi Kaytmaz, Ceyda; Sofuoğlu, Sait CemilCumulative health risk estimation for exposure to mixtures is a current issue, which would present a useful tool for environmental and public health management. Cumulative risks were estimated with response and dose addition methods for individual multi-route - multi-pathway exposure to trihalomethanes and associated carcinogenic toxic risks in Izmir, Turkey. Exposure levels were estimated for ingestion, dermal, and inhalation routes using measured tap water and bottled water THM concentrations. Drinking, showering, hand and dish washing were the considered pathways. THM concentrations in air during the showering were modeled with two-resistance theory using tap water concentration data. The estimated carcinogenic risk levels for ingestion route were in the range of safe (< 10(-6)) to low priority (< 10(-4)), for dermal route all were in the safe zone (< 10(-6)), and for inhalation route were in the range of safe to high priority (> 10(-4)) zones, indicating ingestion and inhalation routes were of similar significance ahead of dermal exposure. Cumulative carcinogenic risks of THM compounds were estimated using simple (response) addition and dose addition using cumulative relative potency factor (CRPF) methods. CRPF method estimated the risks at lower levels compared to the simple addition, which originated from the use two different risk factor values for the index chemical in the method. Cumulative chronic-toxic risks were also assessed, rendering below the threshold risk levels for all routes. This study showed that multi-route - multi-pathway exposure assessment and cumulative risk assessment should together be considered for better environmental and public health management.Article Citation - WoS: 15Citation - Scopus: 16A Mode Shape Assembly Algorithm by Using Two Stage Bayesian Fast Fourier Transform Approach(Academic Press Inc., 2019) Hızal, Çağlayan; Turan, Gürsoy; Aktaş, Engin; Ceylan, HasanOperational modal analysis may require identifying global modal shapes by using multiple setup measurements. For this purpose, various algorithms have been developed which make use of the Bayesian approach to estimate the global mode shapes. The main motivation of the available Bayesian approaches is based on the estimation of the optimal global mode shape vector directly from Fast Fourier Transform data or assembling the local mode shapes that are identified in the individual setups by using Gaussian approximation. In this study, the two-stage Bayesian Fast Fourier Transform Approach which is originally applied to single setups is implemented to multiple setup problems for well separated modes. Analytically it is shown that the resulting formulation is the same for the mode shape assembly by using the Gaussian approximation. In addition, the weights of individual setups in the global mode shape vector is analytically calculated which depend on the Hessian matrix for local mode shapes. To validate the proposed methodology, a numerical example that considers setup-to-setup variability of modal signal-noise ratios is presented. For comparison purposes a ten-story shear frame model is experimentally investigated, and the measurements of a benchmark bridge structure are considered in the verification of the current procedure. (C) 2019 Elsevier Ltd. All rights reserved.Article Citation - WoS: 41Citation - Scopus: 43Chloride or Sulfate? Consequences for Ozonation of Textile Wastewater(Academic Press Inc., 2019) Öktem, Yalçın Aşkın; Yüzer, Burak; Aydın, Muhammed Iberia; Ökten, Hatice Eser; Meriç, Süreyya; Selçuk, HüseyinOzonation of chloride-rich textile wastewater is a common pretreatment practice in order to increase biodegradability and therefore meet the discharge limits. This study is the first to investigate ozone-chloride/bromide interactions and formation of hazardous adsorbable organic halogens (AOX) in real textile wastewater. Initially effect of ozonation on chloride-rich real textile wastewater samples were investigated for adsorbable organic halogens (AOX) formation, biodegradability and toxicity. After 15 min of ozonation, maximum levels of chlorine/bromine generation (0.3 mg/l) and AOX formation (399 mg/l) were reached. OUR and SOUR levels both increased by approximately 58%. Daphnia magna toxicity peaked at 100% for 10 min ozonated sample. Considering adverse effects of ozonation on chloride-rich textile industry effluents, we proposed replacement of NaCl with Na2SO4. Comparative ozonation experiments were carried out for both chloride and sulfate containing synthetic dyeing wastewater samples. Results showed that use of sulfate in reactive dyeing increased biodegradability and decreased acute toxicity. Although sulfate is preferred over chloride for more effective dyeing performance, the switch has been hampered due to sodium sulfate's higher unit cost. However, consideration of indirect costs such as contributions to biodegradability, toxicity, water and salt recovery shall facilitate textile industry's switch from chloride to sulfate.Article Citation - WoS: 24Citation - Scopus: 35Physicochemical and Rheological Properties of Rice-Based Gluten-Free Blends Containing Differently Treated Chickpea Flours(Academic Press Inc., 2018) Kahraman, Gökçen; Harsa, Şebnem; Lucisano, Mara; Cappa, CarolaThis study focused on the evaluation of the physicochemical and rheological properties of chickpea flours and blends obtained by partially substituting rice flour (25 g/100 g) with raw, roasted and dehulled chickpea flour. The characteristics of the resultant doughs were evaluated. In comparison with rice flour, blends containing chickpea flours exhibited high protein and fat content, a reduced retrogradation tendency (setback values of 404–415 vs. 479 Brabender Unit) and a higher foaming capacity and stability, which can be beneficial for their use in baked food formulations. However, roasting decreased foaming capacity and stability. Even if the rheofermentographic test evidenced a slight reduction in dough development, high CO2 retention capacity (≥ 98%) and similar-to-lower leavening times were observed for doughs containing chickpea flours. Incorporating chickpea flours also caused an increase in the viscous and elastic moduli of rice-based doughs, resulting in a good structuring of the dough. The results of this study indicated that chickpea flours could be used as a healthy ingredient in gluten-free rice-based formulations.Article Citation - WoS: 10Citation - Scopus: 12Statistical Approach To Tunneling Time in Attosecond Experiments(Academic Press Inc., 2017) Demir, Durmuş Ali; Güner, TuğrulTunneling, transport of particles through classically forbidden regions, is a pure quantum phenomenon. It governs numerous phenomena ranging from single-molecule electronics to donor–acceptor transition reactions. The main problem is the absence of a universal method to compute tunneling time. This problem has been attacked in various ways in the literature. Here, in the present work, we show that a statistical approach to the problem, motivated by the imaginary nature of time in the forbidden regions, lead to a novel tunneling time formula which is real and subluminal (in contrast to various known time definitions implying superluminal tunneling). In addition to this, we show explicitly that the entropic time formula is in good agreement with the tunneling time measurements in laser-driven He ionization. Moreover, it sets an accurate range for long-range electron transfer reactions. The entropic time formula is general enough to extend to the photon and phonon tunneling phenomena.Book Part Citation - WoS: 4Citation - Scopus: 8Advances in Model-Based Testing of Graphical User Interfaces(Academic Press Inc., 2017) Belli, Fevzi; Beyazıt, Mutlu; Budnik, Christof J.; Tuğlular, TuğkanGraphical user interfaces (GUIs) enable comfortable interactions of the computer-based systems with their environment. Large systems usually require complex GUIs, which are commonly fault prone and thus are to be carefully designed, implemented, and tested. As a thorough testing is not feasible, techniques are favored to test relevant features of the system under test that will be specifically modeled. This chapter summarizes, reviews, and exemplifies conventional and novel techniques for model-based GUI testing.
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