Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - Scopus: 4Comparative Proteomic Analysis of Leishmania Parasites Isolated From Visceral and Cutaneous Leishmaniasis Patients(Cambridge University Press, 2022) Dinç, M.; Yalçln, T.; Çavuş, I.; Özbilgin, A.Leishmaniasis is an infectious disease in which different clinical manifestations are classified into three primary forms: visceral, cutaneous and mucocutaneous. These disease forms are associated with parasite species of the protozoan genus Leishmania. For instance, Leishmania infantum and Leishmania tropica are typically linked with visceral (VL) and cutaneous (CL) leishmaniasis, respectively; however, these two species can also cause other form to a lesser extent. What is more alarming is this characteristic, which threatens current medical diagnosis and treatment, is started to be acquired by other species. Our purpose was to address this issue; therefore, gel-based and gel-free proteomic analyses were carried out on the species L. infantum to determine the proteins differentiating between the parasites caused VL and CL. In addition, L. tropica parasites representing the typical cases for CL were included. According to our results, electrophoresis gels of parasites caused to VL were distinguishable regarding the repetitive down-regulation on some specific locations. In addition, a distinct spot of an antioxidant enzyme, superoxide dismutase, was shown up only on the gels of CL samples regardless of the species. In the gel-free approach, 37 proteins that were verified with a second database search using a different search engine, were recognized from the comparison between VL and CL samples. Among them, 31 proteins for the CL group and six proteins for the VL group were determined differentially abundant. Two proteins from the gel-based analysis, pyruvate kinase and succinyl-coA:3-ketoacid-coenzyme A transferase analysis were encountered in the protein list of the CL group. Copyright © The Author(s), 2021. Published by Cambridge University Press.Article Citation - WoS: 5Citation - Scopus: 4Comparative Proteomic Analysis of Leishmania Parasites Isolated From Visceral and Cutaneous Leishmaniasis Patients(Cambridge University Press, 2021) Dinç, Melike; Yalçın, Talat; Çavuş, İbrahim; Özbilgin, AhmetLeishmaniasis is an infectious disease in which different clinical manifestations are classified into three main forms as visceral, cutaneous, and mucocutaneous. These disease forms are associated with parasite species of protozoan genus, Leishmania. For instance, Leishmania infantum and Leishmania tropica are typically linked with visceral (VL) and cutaneous (CL) leishmaniasis respectively, however these two species can also cause other form to a lesser extent. What is more alarming is this characteristic, which threatens classic diagnoses and therapies, is started to be acquired by other species. To address this issue, gel-based and gel-free proteomic analyses were carried out on the species, Leishmania infantum to determine the proteins differentiating between the parasites caused visceral and cutaneous leishmaniasis. In addition, Leishmania tropica parasites representing the typical cases for cutaneous leishmaniasis were included. Electrophoresis gels of parasites caused to visceral leishmaniasis were distinguishable from the others in terms of repetitive down-regulation on some specific locations. In addition, a distinct spot of an antioxidant enzyme, superoxide dismutase was shown up only on the gels of cutaneous leishmaniasis samples regardless of the species. In the gel-free approach, 37 proteins which were verified with a second database search using a different search engine, were distinguished from the comparison between VL and CL samples. Among them, 31 proteins for the CL group and 6 proteins for the VL group were determined differentially abundant. Two proteins from the gel-based analysis namely pyruvate kinase and succinly-coA:3-ketoacid-coenzyme A transferase analysis were encountered in the protein list of the CL group.Article Citation - WoS: 3Citation - Scopus: 6Use of Analogies, Metaphors, and Similes by Students and Reviewers at an Undergraduate Architectural Design Review(Cambridge University Press, 2019) Doğan, Fehmi; Taneri, Batuhan; Erbil, LivanurThis study investigates the use of similarities in the form of analogy, metaphor, and simile by students and reviewers in an undergraduate architectural design review. In contrast to studies conducted in vitro settings, this study emphasizes the importance of studying analogies, metaphors, and similes in a natural setting. All similarity relationships were coded according to their type, the level of expertise, range, frequency, goal, value judgment, and depth. The results indicate that analogies, metaphors, and similes were used spontaneously and without any difficulty by both reviewers and students. Reviewers, however, were almost twice as likely to evoke similarities. Metaphor was the most frequently used similarity relationship among the three. It was found that there was a significant relationship between the level of expertise and type of similarity, with students more likely to use analogies and less likely to use similes. It was also found that goal is the most important factor, with a significant relation to all other variables, and that embodiment is often invoked in both students' and reviewers' metaphors. We conclude that design education should take full advantage of students' natural ability to benefit from similarity relationships.Article Citation - WoS: 81Citation - Scopus: 79The Resonant Nonlinear Schrödinger Equation in Cold Plasma Physics. Application of Bäcklund-Darboux Transformations and Superposition Principles(Cambridge University Press, 2007) Lee, Jiunhung; Pashaev, Oktay; Rogers, Colin; Schief, W. K.A system of nonlinear equations governing the transmission of uni-axial waves in a cold collisionless plasma subject to a transverse magnetic field is reduced to the recently proposed resonant nonlinear Schrödinger (RNLS) equation. This integrable variant of the standard nonlinear Schrödinger equation admits novel nonlinear superposition principles associated with Bäcklund-Darboux transformations. These are used here, in particular, to construct analytic descriptions of the interaction of solitonic magnetoacoustic waves propagating through the plasma.Article Citation - WoS: 3Citation - Scopus: 2Prediction of Microdrill Breakage Using Rough Sets(Cambridge University Press, 2011) Sevil, Hakkı Erhan; Özdemir, SerhanThis study attempts to correlate the nonlinear invariants’ with the changing conditions of a drilling process through a series of condition monitoring experiments on small diameter (1 mm) drill bits. Run-to-failure tests are performed on these drill bits, and vibration data are consecutively gathered at equal time intervals. Nonlinear invariants, such as the Kolmogorov entropy and correlation dimension, and statistical parameters are calculated based on the corresponding conditions of the drill bits. By intervariations of these values between two successive measurements, a drop–rise table is created. Any variation that is within a certain threshold (+-20% of the measurements in this case) is assumed to be constant. Any fluctuation above or below is assumed to be either a rise or a drop. The reduct and conflict tables then help eliminate incongruous and redundant data by the use of rough sets (RSs). Inconsistent data, which by definition is the boundary re-gion, are classified through certainty and coverage factors. By handling inconsistencies and redundancies, 11 rules are ex-tracted from 39 experiments, representing the underlying rules. Then 22 new experiments are used to check the validity of the rule space. The RS decision frame performs best at predicting no failure cases. It is believed that RSs are superior in dealing with real-life data over fuzzy set logic in that actual measured data are never as consistent as here and may dominate the monitoring of the manufacturing processes as it becomes more widespread.Article Citation - WoS: 10Citation - Scopus: 10Special Precovers in Cotorsion Theories(Cambridge University Press, 2002) Akıncı, Karen D.; Alizade, RafailA cotorsion theory is defined as a pair of classes Ext-orthogonal to each other. We give a hereditary condition (HC) which is satisfied by the (flat, cotorsion) cotorsion theory and give properties satisfied by arbitrary cotorsion theories with an HC. Given a cotorsion theory with an HC, we consider the class of all modules having a special precover with respect to the first class in the cotorsion theory and show that this class is closed under extensions. We then raise the question of whether this class is resolving or coresolving.