Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 4Citation - Scopus: 4A Polymeric Copper Complex Based on a Pyrazole Derivative: Synthesis, Spectroscopic, X-Ray, and Biological Activity Studies(John Wiley and Sons Inc., 2024) Amin,M.A.; Diker,H.; Şahin,O.; Varlıklı, Canan; Soliman,A.A.A novel 1D coordination polymeric copper complex based on 4-(4′-nitrophenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was prepared and characterized spectroscopically and thermally and via X-ray crystallographic investigation. The prepared copper-based structure was proved to have a 1D coordination polymer. X-ray studies showed that the polymeric copper complex was of octahedral geometry, the ligand acted as a bidentate ligand, and the nitro group attached to the ligand acted as a bridging group. The cytotoxic activities of the copper polymer were evaluated including against MCF-7 cells (breast cancer cell line), HepG-2 cells (hepatocellular carcinoma), and HCT-116 cells (colon cancer cell line). The morphological alterations of the complex treated cells were investigated using an inverted microscope. The cell cycle and apoptosis were evaluated and reported. The copper polymer exhibited the best antitumor activity against HepG-2 cells (35.22 ± 4.80 μM) while also causing a decline in the G2/M phase and a remarkable enhancement in the early apoptosis. © 2024 John Wiley & Sons, Ltd.Article Citation - WoS: 18Citation - Scopus: 22A Review of Heat and Fluid Flow Characteristics in Microchannel Heat Sinks(John Wiley and Sons Inc., 2020) Coşkun, Turgay; Çetkin, ErdalHeat transfer and flow characteristic in microchannel heat sinks (MCHS) are extensively studied in the literature due to high heat transfer rate capability by increased heat transfer surface area relative to the macroscale heat sinks. However, heat transfer and fluid flow characteristics in MCHS differ from conventional ones because of the scaling effects. This review summarizes the studies that are mainly based on heat transfer and fluid flow characteristic in MCHS. There is no consistency among the published results; however, everyone agrees on that there is no new physical phenomenon in microscale that does not exist at macroscale. Only difference between them is that the effect of some physical phenomena such as viscous dissipation, axial heat conduction, entrance effect, rarefaction, and so forth, is negligibly small at macroscale, whereas it is not at microscale. The effect of these physical phenomena on the heat transfer and flow characteristics becomes significant with respect to specified conditions such as Reynolds number, Peclet number, hydraulic diameter, and heat transfer boundary conditions. Here, the literature was reviewed to document when these physical phenomena become significant and insignificant.Article Citation - WoS: 2Citation - Scopus: 2Transition-Metal Direct C-H Arylation of Thiophene in Aqueous Media Via Potassium Peroxymonosulfate(John Wiley and Sons Inc., 2019) Özenler, Sezer; Kaya, Hakan; Elmacı, Nuran; Yıldız, Ümit HakanThis study covers the use of potassium peroxymonosulfate (PPS) which, is a mild and inexpensive catalyst, for direct coupling of C-H/C-H for water soluble thiophene. The 3-(4-methyl-3 '- thienyloxy)propyltriethylammonium bromide (M1) has been selected as model monomer that reacted PPS in 2.0, 0.20 and 0.020 monomer to PPS ratio. The reaction has been monitored via NMR spectroscopy revealing the monomer consumption and formation of dimers to tetramers as well as completion of reaction within 15 minutes. Resultant product is easily collected without tedious work up steps. The computational calculation has optimized the regularity of the coupling as head to tail, tail to tail, head to tail (HT-TT-HT) for tetramer. The regularity of tetramer which is further satisfied via NMR analysis showing emergence of new peaks at 3.56 and 4.48. The shifts in the UV maximum of reactive species have been monitored by absorbance spectroscopy showing time dependent red shift corresponds to growing from monomer to tetramers. The reaction has self-stopped due to low solubility of moderate condensates (higher than trimer), however further experiments have performed in water-organic mixtures showed great promises to obtain higher condensates.Article Citation - WoS: 15Citation - Scopus: 17Improved Activity of Alpha-L From Geobacillus Vulcani Gs90 by Directed Evolution: Investigation on Thermal and Alkaline Stability(John Wiley and Sons Inc., 2019) Sürmeli, Yusuf; İlgü, Hüseyin; Şanlı Mohamed, Gülşahalpha-L-Arabinofuranosidase (Abf) is a potential enzyme because of its synergistic effect with other hemicellulases in agro-industrial field. In this study, directed evolution was applied to Abf from Geobacillus vulcani GS90 (GvAbf) using one round error-prone PCR and constructed a library of 73 enzyme variants of GvAbf. The activity screening of the enzyme variants was performed on soluble protein extracts using p-nitrophenyl alpha-L-arabinofuranoside as substrate. Two high activity displaying variants (GvAbf L307S and GvAbf Q90H/L307S) were selected, purified, partially characterized, and structurally analyzed. The specific activities of both variants were almost 2.5-fold more than that of GvAbf. Both GvAbf variants also exhibited higher thermal stability but lower alkaline stability in reference to GvAbf. The structural analysis of GvAbf model indicated that two mutation sites Q90H and L307S in both GvAbf variants are located in TIM barrel domain, responsible for catalytic action in many Glycoside Hydrolase Families including GH51. The structure of GvAbf model displayed that the position of L307S mutation is closer to the catalytic residues of GvAbf compared with Q90H mutation and also L307S mutation is conserved in both variants of GvAbf. Therefore, it was hypothesized that L307S amino acid substitution may play a critical role in catalytic activity of GvAbf. (C) 2018 International Union of Biochemistry and Molecular Biology, Inc.Article Citation - WoS: 3Citation - Scopus: 4Impact Loading and Modelling a Multilayer Aluminium Corrugated/Fin Core: the Effect of the Insertion of Imperfect Fin Layers(John Wiley and Sons Inc., 2019) Sarıkaya, Mustafa; Taşdemirci, Alper; Güden, MustafaThe quasi-static compression (0.0048 m/s) and Taylor-like impact (135, 150, and 200 m/s) loading of a multilayer 1050 H14 aluminium corrugated core were investigated both experimentally and numerically in LS-DYNA using the perfect and imperfect sample models. In the imperfect sample models, one or two layers of corrugated fin structure were replaced by the fin layers made of bent-type cell walls. The localised deformation in the quasi-static imperfect models of cylindrical sample started at the imperfect layers, the same as the tests, and the layers were compressed until about the densification strain in a step-wise fashion. The localised deformation in the perfect models, however, started at the layers at and near the top and bottom of the test sample. In the shock mode, the sample crushed sequentially starting at the impact end layer regardless the perfect or imperfect sample models were used. Furthermore, the perfect and imperfect models resulted in nearly the same initial crushing stresses in the shock mode. The layer strain histories revealed a velocity-dependent layer densification strain. Both model types, the imperfect and perfect, well approximated the stress-time histories and layer deformations of the shock mode. The rigid perfectly plastic locking model based on the numerically determined densification strains also showed well agreements with the experimental and numerical plateau stresses of the shock mode.Article Citation - WoS: 9Citation - Scopus: 9Modification of Commercial Boron Carbide Powder Using Rapid Carbothermal Reduction(John Wiley and Sons Inc., 2019) Toksoy, Muhammet Fatih; Haber, Richard A.Non-uniform morphology and existence of free carbon are two main problems for commercial boron carbide powders. This work proposes a method for eliminating free carbon and changing the morphology of commercial powders using Rapid Carbothermal Reduction (RCR) process. Free carbon is eliminated from commercial boron carbide powders and morphology is evolved to less angular shapes with limited particle size growth. Commercial and modified powders were densified by Spark Plasma Sintering at 1900 degrees C with 0, 5, and 20 minutes dwell. Despite the particle size growth, modified boron carbide powders reached >99% TD with shorter dwell times compared with commercial starting powders. Improved microhardness observed with dense modified samples as a result of enhanced morphology and increased twinning.Article On Smoothers for Multigrid of the Second Kind(John Wiley and Sons Inc., 2019) Aksoylu, Burak; Kaya, AdemWe study smoothers for the multigrid method of the second kind arising from Fredholm integral equations. Our model problems use nonlocal governing operators that enforce local boundary conditions. For discretization, we utilize the Nystrom method with the trapezoidal rule. We find the eigenvalues of matrices associated to periodic, antiperiodic, and Dirichlet problems in terms of the nonlocality parameter and mesh size. Knowing explicitly the spectrum of the matrices enables us to analyze the behavior of smoothers. Although spectral analyses exist for finding effective smoothers for 1D elliptic model problems, to the best of our knowledge, a guiding spectral analysis is not available for smoothers of a multigrid of the second kind. We fill this gap in the literature. The Picard iteration has been the default smoother for a multigrid of the second kind. Jacobi-like methods have not been considered as viable options. We propose two strategies. The first one focuses on the most oscillatory mode and aims to damp it effectively. For this choice, we show that weighted-Jacobi relaxation is equivalent to the Picard iteration. The second strategy focuses on the set of oscillatory modes and aims to damp them as quickly as possible, simultaneously. Although the Picard iteration is an effective smoother for model nonlocal problems under consideration, we show that it is possible to find better than ones using the second strategy. We also shed some light on internal mechanism of the Picard iteration and provide an example where the Picard iteration cannot be used as a smoother.Book Part Citation - Scopus: 3Infrared Spectroscopy for the Detection of Adulteration in Foods(John Wiley and Sons Inc., 2012) Özen, Banu; Tokatlı, FigenIR spectroscopy in combination with chemometric techniques is an effective tool for the detection of adulteration of high economic value food products such as wine, dietary supplements and olive oil. It provides practical and quick alternative to other commonly used analytical methods.Article Citation - WoS: 24Citation - Scopus: 25Prospects for Cellulosic Biofuel Production in the Northeastern United States: a Scenario Analysis(John Wiley and Sons Inc., 2016) Dilekli, Naci; Duchin, FayeSecure access to energy and food are two of the challenges facing the Northeast region of the United States. Traditional biofuel feedstocks, such as corn and oil seed, are able to satisfy energy requirements. However, they compete with food production for desirable land and water resources and, in any case, are not likely to exploit the region's current comparative advantages. This study investigates a potential solution to the energy security problem in the Northeast: biofuel from advanced feedstock in the form of net forest growth and woody wastes, of which the region has abundant endowments. The federal government has committed to requiring 79.5 billion liters (BL) of advanced biofuel production annually by 2022. We evaluate both the physical capacity for its production and its cost competitiveness using an input-output model of consumption, production, and trade in the 13-state region. The model minimizes resource use required to satisfy given consumer demand using alternative technological options and subject to resource constraints. We compile data from the technical literature quantifying state-level biofuel feedstock endowments and the technological requirements for cellulosic ethanol production. We find that exploiting the region's endowment of cellulosic feedstock requires either making the price of biofuels competitive with gasoline through subsidies or restricting imports of gasoline. Based on this initial investigation, we conclude that the region can produce significant amounts of advanced biofuel, up to 20.28 BL of cellulosic ethanol per year, which could displace nearly 12.5% of the gasoline that is now devoted to motorized transport in the region.Article Citation - WoS: 17Citation - Scopus: 18Development of an Ionic Liquid Based Method for the Preparation of Albumin Nanoparticles(John Wiley and Sons Inc., 2018) Demirkurt, Begüm; Akdoğan, YaşarAlbumin based nanocarriers have been widely used in drug delivery studies. Here, we developed a water-in-ionic liquid (IL) emulsion-like method to prepare bovine serum albumin (BSA) nanoparticles as alternative to the traditional organic solvents containing techniques. Conformational changes of albumin induced by the imidazolium based ILs at the water-IL interface triggers the BSA nanoparticle formation. The albumin nanoparticle formation are dependent on the experimental parameters and the hydophobicity of the IL. At pH 9.0, using 1.3%wt of BSA in water/1-butyl-3-methyl imidazolium tetrafluoroborate (BmimBF4) (50/50 mol%) and TX-100/butanol surfactant mixture yields uniformly distributed 200 nm average sized BSA nanoparticles. Different than BmimBF4, using a more hydrophilic IL, EmimBF4 yielded albumin aggregates. Instead, using a more hydrophobic IL, HmimBF4 produced albumin nanoparticles but a non-uniform size distribution was obtained. These results indicate that the ionic liquids called green and designer solvents can be also used to synthesize albumin nanoparticles.