Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Interaction of Hazelnut-Derived Polyphenols With Biodegradable Film Matrix: Structural, Barrier, and Functional Properties(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Hızır-Kadı, I.; Demircan, E.; Özçelik, B.The study presents a sustainable approach to valorizing hazelnut processing by-products, specifically skins and shells, through their conversion into bioactive polyphenol-rich extracts using pressurized hot water extraction (PHWE), an environmentally friendly green technology. PHWE yielded extracts with total phenolic contents of 25.4 mg GAE/g dw (shell) and 83.7 mg GAE/g dw (skin), which were incorporated into biodegradable poly(vinyl alcohol)/carboxymethyl cellulose (PVA/CMC) films at concentrations of 1–3% (w/v). The resulting composites were comprehensively characterized in terms of structural, mechanical, thermal, and barrier properties. FTIR, DSC, and XRD analyses demonstrated strong hydrogen bonding, increased thermal stability, and reduced crystallinity due to polyphenol–polymer interactions. Phenolic incorporation enhanced UV-blocking capability, increased antioxidant activity by up to five-fold, and reduced oxygen permeability from 0.048 to 0.015 (cm3·mm·m−2·day−1·atm−1) (69% reduction, p < 0.05), compared to neat PVA while maintaining desirable transparency (>70%). Optimal formulations (HSkE-II) exhibited a 39% increase in elongation at break and improved flexibility without compromising film integrity. Application tests using fresh-cut apples, watermelon, and chicken revealed significant reductions in microbial growth (up to ~1.2 log CFU/g), lipid oxidation, and weight loss during storage, confirming the films’ potential for active food packaging. This work highlights an efficient valorization strategy for nut industry by-products and demonstrates their functional integration into sustainable biodegradable packaging systems. © 2025 by the authors.Article A Study of the Environmental Challenges En Marche Towards Net-Zero: Case Study of Turkish Steel Industry(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Özdamar, A.B.; Kaya, M.; Bektas, A.; Bhattacharyya, S.; Şahindoğan, M.; Birat, Jean-Pierre; Dutta, A.The Turkish steel industry aims to reduce its sectoral carbon dioxide (CO<inf>2</inf>) emissions by 55% by 2030, in line with Türkiye’s Paris Agreement commitments and the European Green Deal (EGD), and consistent with the ambition of the European Union’s economy-wide ‘Fit for 55’ emissions-reduction target. Türkiye faces significant challenges in achieving net-zero greenhouse gas (GHG) emissions, particularly as a developing country confronting the impacts of climate change and in the market situation, such as the effects of the ongoing Russia-Ukraine conflict, limited access to affordable raw materials, and rising operational costs. This study serves as a guideline for the Turkish steel sector’s roadmap towards modernization and eventual compliance with net-zero targets. The consideration and integration of new technologies planned for the Turkish steel industry, in both electric arc furnace (EAF) and blast furnace-basic oxygen furnace (BF-BOF) facilities, have been outlined in conjunction with green hydrogen and with Carbon Capture and Storage (CCS) technologies. Four different scenarios were analysed to understand the reduction in CO<inf>2</inf> emissions: (1) In a Business-As-Usual (BAU) scenario without any reduction, (2) 39.9% CO<inf>2</inf> emission reduction with the Moderate scenario, (3) 59.6% reduction with the Advanced scenario, and (4) 82.9% reduction in CO<inf>2</inf> emissions from the Turkish steel sector with the Net-Zero scenario. To quantify the uncertainty in these long-term projections, a Monte Carlo simulation was conducted, generating probabilistic confidence intervals that reinforce the robustness and credibility of the net-zero pathway. The official roadmap for the sector is not available as of today; however, an in-depth discussion with a policy innovation leading to it is the objective of this study. © 2026 by the authors.Article Dysfunctional K+ Homeostasis as a Driver for Brain Inflammation(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Ozsoy, Nagihan; Dallas, Mark L.The central nervous system (CNS) relies on precise regulation of potassium ion (K+) concentrations to maintain physiology. This regulation involves complex cellular and molecular mechanisms that work in concert to regulate both intracellular and extracellular K+ levels. Inflammation, a key physiological response, encompasses a series of cell-specific events leading to inflammasome activation. Perturbations in K+-sensitive processes can result in either chronic or uncontrolled inflammation, highlighting the intricate relationship between K+ homeostasis and inflammatory signalling. This review explores molecular targets that influence K+ homeostasis and have been implicated in inflammatory cascades, offering potential therapeutic avenues for managing inflammation. We examine both cell-specific and common molecular targets across different cell types, providing a comprehensive overview of the interplay between K+ regulation and inflammation in the CNS. By elucidating these mechanisms, we identify leads for drug discovery programmes aimed at modulating inflammatory responses. Additionally, we highlight potential consequences of targeting individual molecular entities for therapeutic purposes, emphasizing the need for a nuanced approach in developing anti-inflammatory strategies. This review considers current knowledge on K+-sensitive inflammatory processes within the CNS, offering critical insights into the molecular underpinnings of inflammation and potential therapeutic interventions. Our findings underscore the importance of considering K+ homeostasis in the development of targeted therapies for inflammatory conditions within the CNS. © 2025 Elsevier B.V., All rights reserved.