Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Subject: search.filters.subject.Microchannels

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  • Article
    Citation - WoS: 18
    Citation - Scopus: 19
    Hand-Held Volatilome Analyzer Based on Elastically Deformable Nanofibers
    (American Chemical Society, 2018) Yücel, Müge; Akın, Osman; Çayören, Mehmet; Akduman, İbrahim; Palaniappan, Alagappan; Liedberg, Bo; Hızal, Gürkan; İnci, Fatih; Yıldız, Ümit Hakan
    This study reports on a hand-held volatilome analyzer for selective determination of clinically relevant biomarkers in exhaled breath. The sensing platform is based on electrospun polymer nanofiber-multiwalled carbon nanotube (MWCNT) sensing microchannels. Polymer nanofibers of poly(vinylidene fluoride) (PVDF), polystyrene (PS), and poly(methyl methacrylate) (PMMA) incorporated with MWCNT exhibits a stable response to interferences of humidity and CO2 and provides selective deformations upon exposure of exhaled breath target volatilomes acetone and toluene, exhibiting correlation to diabetes and lung cancer, respectively. The sensing microchannels "P1" (PVDF-MWCNT), "P2" (PS-MWCNT), and "P3" (PMMA-MWCNT) are integrated with a microfluidic cartridge (μ-card) that facilitates collection and concentration of exhaled breath. The volatilome analyzer consists of a conductivity monitoring unit, signal conditioning circuitries and a low energy display module. A combinatorial operation algorithm was developed for analyzing normalized resistivity changes of the sensing microchannels upon exposure to breath in the concentration ranges between 35 ppb and 3.0 ppm for acetone and 1 ppb and 10 ppm for toluene. Subsequently, responses of volatilomes from individuals in the different risk groups of diabetes were evaluated for validation of the proposed methodology. We foresee that proposed methodology provides an avenue for rapid detection of volatilomes thereby enabling point of care diagnosis in high-risk group individuals.
  • Article
    Citation - WoS: 10
    Citation - Scopus: 10
    Constructal Microdevice Manifold Design With Uniform Flow Rate Distribution by Consideration of the Tree-Branching Rule of Leonardo Da Vinci and Hess-Murray Rule
    (The American Society of Mechanical Engineers(ASME), 2017) Çetkin, Erdal
    In this paper, we show how the design of a microdevice manifold should be tapered for uniform flow rate distribution. The designs based on the tree-branching rule of Leonardo da Vinci and the Hess-Murray rule were considered in addition to the constructal design. Both da Vinci and Hess-Murray designs are insensitive to the inlet velocity, and they provide better flow uniformity than the base (not tapered) design. However, the results of this paper uncover that not only pressure drop but also velocity distribution in the microdevice play an integral role in the flow uniformity. Therefore, an iterative approach was adopted with five degrees-of-freedom (inclined wall positions) and one constraint (constant distribution channel thickness) in order to uncover the constructal design which conforms the uniform flow rate distribution. In addition, the effect of slenderness of the microchannels (Svelteness) and inlet velocity on the flow rate distribution to the microchannels has been documented. This paper also uncovers that the design of a manifold should be designed with not only the consideration of pressure distribution but also dynamic pressure distribution especially for non-Svelte microdevices.