WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 18Citation - Scopus: 22Biomimetic Dentin Repair: Amelogenin-Derived Peptide Guides Occlusion and Peritubular Mineralization of Human Teeth(American Chemical Society, 2023) Fong, Hanson; Hamann, John; Hall, Eric; Yücesoy, Deniz T.; Doğan, Sami; Sarıkaya, MehmetExposure of dentin tubules due to loss of protective enamel (crown) and cementum (root) tissues as a result of erosion, mechanical wear, gingival recession, etc. has been the leading causes of dentin hypersensitivity. Despite being a widespread ailment, no permanent solution exists to address this oral condition. Current treatments are designed to alleviate the pain by either using desensitizers or blocking dentin tubules by deposition of minerals or solid precipitates, which often have short-lived effects. Reproducing an integrated mineral layer that occludes exposed dentin with concomitant peritubular mineralization is essential to reestablish the structural and mechanical integrity of the tooth with long-term durability. Here, we describe a biomimetic treatment that promotes dentin repair using a mineralization directing peptide, sADP5, derived from amelogenin. The occlusion was achieved through a layer-by-layer peptide-guided remineralization process that forms an infiltrating mineral layer on dentin. The structure, composition, and nanomechanical properties of the remineralized dentin were analyzed by cross-sectional scanning electron microscopy imaging, energy dispersive X-ray spectroscopy, and nanomechanical testing. The elemental analysis provided calcium and phosphate compositions that are similar to those in hydroxyapatite. The measured average hardness and reduced elastic modulus values for the mineral layer were significantly higher than those of the demineralized and sound human dentin. The structural integration of the new mineral and underlying dentin was confirmed by thermal aging demonstrating no physical separation. These results suggest that a structurally robust and mechanically durable interface is formed between the interpenetrating mineral layer and underlying dentin that can withstand long-term mechanical and thermal stresses naturally experienced in the oral environment. The peptide-guided remineralization procedure described herein could provide a foundation for the development of highly effective oral care products leading to novel biomimetic treatments for a wide range of demineralization-related ailments and, in particular, offers a potent long-term solution for dentin hypersensitivity.Article Citation - WoS: 10Citation - Scopus: 10Comparison of the Rermineralisation Effect of a Glass Ionomer Cement Versus a Resin Composite on Dentin of Primary Teeth(Ariesdue Srl, 2014) Aykut-Yetkiner, A.; Simsek, D.; Eronat, C.; Ciftcioglu, M.Aim The aim of this study was to investigate the interaction of a high viscosity glass ionomer cement (G/C) and a composite resin with caries affected dentin and to determine the remineralization levels. Materials and Methods In a split Mouth deSign 24 GIC and composite resin atraumatic restorative treatment restorations were made in vivo and the teeth were collected after 2 years and subsequently settioned and examined using Vickers microhardness test; the latter was performed starting from the dentin surfate adjacent to the restoration. Repeated Measure ANOVA and Bonferroni Statistical methods were used for data analysis. Results The micrdhardness adjacent to the GIC reStorative material resulted tube significantly higher. Conclusion GIC resulted to be a better restorative material for the remineralization of caries affected dentin, though further studies are necessary for the corroboration of this finding. The GIC restored primary molar dentin had a higher level of remineralizatiOn and GIC could be the material of chdice in pediatric dentistry.