WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Rice-Like, Hollow, and Rhombohedral Nano-Calcite Synthesis by Carbonization(Elsevier, 2026) Kilic, Sevgi; Toprak, Gorkem; Ozdemir, EkremControlling the morphology and size of calcium carbonate (CaCO3) remains an essential challenge in the production of high-performance fillers and advanced functional materials. Here, we report a continuous carbonization strategy that enables the synthesis of monodisperse nano-calcite particles with tunable rice-like, hollow, and rhombohedral morphologies through precise control of CO2 dissolution into a flowing Ca(OH)2 solution under diffusion-limited conditions. A two-stage reactor was designed to decouple nucleation and growth by separating the gas-liquid interaction zone from a stabilization tank. pH and conductivity analyses revealed that crystallization is primarily governed by the CO2 dissolution kinetics rather than mixing intensity in the stabilization tank. SEM and XRD analyses demonstrate a distinct crystallization sequence such that initial formation of rice-like calcite, subsequent development of hollow nanoparticles through selective tip dissolution, and final transformation into rhombohedral calcite via dissolution-reprecipitation mechanism. The method provides a reproducible, template-free route for fabricating hollow CaCO3 nanoparticles, overcoming limitations of bubbletemplating and additive-mediated techniques. This scalable process provides a robust foundation for producing high-surface-area CaCO3 nanomaterials which have potential applications in thin films, ceramics, protective coatings, lightweight composites, thermal/acoustic insulation, adsorption, and catalysis, where tailored particle morphology and size can significantly enhance performance.Article Comparison of the Photoresponse Characteristics for 4H-SiC Schottky Barrier UV Photodetector with Graphene and Ni/Cr Electrode(Elsevier, 2026) Dulcel, Atilla Mert; Gozek, Melike; Unverdi, Ozhan; Celebi, CemGr/4H-SiC and Ni/Cr/4H-SiC Schottky junction UV photodetectors were fabricated and investigated to reveal the effect of electrode materials on the device performance such as spectral response and response speed. I-V characterization, spectral response, and response speed (on-off) measurements were conducted for the UV wavelength range between 200 and 400 nm. The maximum photo-responsivity was obtained as 0.081 A/W for Gr/4H-SiC and 0.041 A/W for Ni/Cr/4H-SiC at a wavelength of 260 nm. This result was attributed to the higher optical transmittance of the graphene electrode compared to the semitransparent Ni/Cr electrode. Zero bias response speed measurements were done under 280 nm wavelength UV light pulsed at different frequencies such as 100 Hz, 500 Hz, and 1000 Hz. The Gr/4H-SiC and Ni/Cr/4H-SiC photodetectors show distinctly different decay times of 5.04 ms and 305.1 mu s, respectively, while their rise times were found to be similar. This observation has been explained by the inclination of graphene to act as a trap site for photogenerated holes.Article Continuous Direct Lithium Extraction from Seawater Via an Unconventional Selective Solid Electrolyte(Elsevier, 2026) Li, Jinghui; Gao, Jiaxuan; Yu, Zihao; Yan, Linxue; Guo, Yafei; Demir, Mustafa; Deng, TianlongWith the significant depletion of terrestrial lithium resources, attention has shifted toward seawater, which holds the largest lithium reserves on Earth. However, extracting lithium from seawater presents a complex challenge due to its intricate composition and extremely low concentration of lithium ions. Herein, we demonstrated inexpensive Li4Ti5O12 as a selective solid electrolyte for direct lithium extraction from seawater. It extracted lithium ions from seawater at an initial concentration of 0.17 mg/L and enriched them to 22.25 mg/L in the receiving solution. The sodium and magnesium ion concentrations were only 33.5 mg/L and 0.66 mg/L. The Li/ Na selectivity (SLi/Na) and Li/Mg selectivity (SLi/Mg) were remarkably high, reaching 42,000 and 240,000, respectively. Furthermore, DFT showed that the energy required for both processes-desolvation of sodium ions and migration of ions within the crystal-is significantly higher than that for lithium ions, which explains the high selectivity of this method. XAS and XRD refinement revealed that the lithium-ion conductor remained stable without any decomposition. In addition, we designed a comprehensive process using the phase equilibrium method, enabling the direct separation of lithium hydroxide without waste when Li4Ti5O12 serves as the selective solid-state electrolyte, thereby highlighting its strong potential for industrial applications.Article Design, Synthesis, and Evaluation of Anticancer Activities of 1,2-Diborolane Derivatives for Hepatocellular Carcinoma: an in Vitro and in Silico Study(Elsevier, 2026) Sahin, Yuksel; Antika, Gizem; Aktan, Cagdas; Metin, Kubilay; Ozgener, HuseyinHepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer and remains a major global health challenge due to limited treatment options and poor prognosis. Boron-containing compounds have garnered attention for their diverse biological activities, including pro-apoptotic effects in various types of cancer. In this study, we synthesized a panel of novel 1,2-N-substituted-1,2-diborolane derivatives and evaluated their antiproliferative, antimigratory, and apoptotic effects on hepatocellular carcinoma cell lines, HepG2 and Hep3B. Spectroscopic analyses confirmed the structural integrity of the synthesized compounds, revealing characteristic 1H-, 11B-, and 13C-NMR shifts consistent with boron-oxygen and boron-nitrogen bonding patterns. The derivatives, particularly compounds 2, 3, and 6, demonstrated potent and selective cytotoxicity toward HCC cells, with compound 3 exhibiting the lowest IC50 value (6.75 mu M) in HepG2 cells. Their time-dependent anti-proliferative effects were further supported by colony formation assays demonstrating long-term growth suppression, while wound healing assays revealed marked inhibition of HepG2 cell migration, indicating the compound's anti-metastatic potential. Our results demonstrate that the compound significantly induces apoptosis, modulates the expression of key apoptotic genes (Bax, Bcl-2, and caspase-3). In silico molecular docking further confirmed strong binding affinity to the anti-apoptotic Bcl-2 protein, supporting the proposed mechanism of action. These findings highlight the compound as a promising candidate for further preclinical evaluation in liver cancer therapy.Article Citation - WoS: 20Citation - Scopus: 17Optimizing Thermal Comfort in Physical Exercise Spaces: A Study of Spatial and Thermal Factors(Elsevier, 2024) Avcı, A.B.; Balci, G.A.; Başaran, T.Fitness centers have become famous for maintaining a healthy lifestyle. They require different thermal comfort conditions and higher fresh air supply rates than other indoor spaces. However, even well-designed centers may cause discomfort due to factors such as design decisions, ventilation, overheating, and overcrowding. The standards for fitness centers do not consider these specific requirements sufficiently, so this study focuses on understanding the thermal comfort requirements during physical exercise and evaluating spatial and thermal factors affecting the thermal environment around the body. The study investigated the ceiling height, lateral and frontal distances between machines, and vent locations as spatial factors and inlet temperature and air velocity as thermal factors. A thirty-minute moderate-intensity constant work rate exercise test was conducted in a controlled climatic chamber using a cycle ergometer with six healthy male participants. The experiment conditions were simulated in CFD software using the collected data. Once a validated simulation model was provided, computational models for different environmental and spatial scenarios for the five-person cycling class were generated. Using Taguchi L9 (34) orthogonal arrays method, nine spatial scenarios were simulated with three different thermal operations each. Optimal factor levels were determined by using thermal comfort conditions (based on predicted mean vote) around the body's thermal plume. The results showed that a ceiling height of 5 m, lateral and frontal distances of 1 m and 0.5 m between machines, and Type 2 (two inlets mounted on the ceiling) ventilation strategy were optimal for achieving better thermal comfort values in a thermal condition of 18 °C and 0.2 m·s−1. The study found that increasing the ceiling height and using cross-positioned vents that project air vertically from the ceiling improved the comfort conditions significantly. It is expected that these criteria, which were determined, compared with the standards and detailed, will contribute to the production processes of comfortable exercise spaces. © 2023 Elsevier B.V.Article Citation - WoS: 8Citation - Scopus: 10Impact of Simulated Inflammation and Food Breakdown on the Synergistic Interaction Between Corrosion and Wear on Titanium(Elsevier, 2024) Lima, A.R.; Pinto, A.M.P.; Toptan, F.; Alves, A.C.This paper investigates the impact of lactic acid and phosphoric acid additives in artificial saliva (AS), simulating inflammation and food breakdown, on the electrochemical and tribo-electrochemical behavior of titanium. The results showed that, unlike lactic acid, phosphoric acid significantly reduced corrosion resistance, mainly due to local damage and heterogeneities on the passive film. Non-additivated AS caused greater wear volume loss, with mechanical wear identified as the main mechanism. However, when additives were present, a synergistic interplay between corrosion and wear was observed. The study concludes that prolonged exposure to food breakdown could accelerate material degradation in titanium. © 2024 Elsevier LtdArticle Citation - WoS: 40Citation - Scopus: 38Anisotropic and Outstanding Mechanical, Thermal Conduction, Optical, and Piezoelectric Responses in a Novel Semiconducting Bcn Monolayer Confirmed by First-Principles and Machine Learning(Elsevier, 2022) Mortazavi, Bohayra; Fazel Shojaei; Yağmurcukardeş, Mehmet; Alexander Shapeev; Xiaoying ZhuangGraphene-like nanomembranes made of the neighboring elements of boron, carbon and nitrogen elements, are well-known of showing outstanding physical properties. Herein, with the aid of density functional theory (DFT) calculations, various atomic configurations of the graphene-like BCN nanosheets are investigated. DFT results reveal that depending on the atomic arrangement, the BCN monolayers may display semimetallic Dirac cone or semiconducting electronic nature. BCN nanosheets are also found to exhibit high piezoelectricity and carrier mobilities with considerable in-plane anisotropy, depending on the atomic arrangement. For the predicted most stable BCN monolayer, thermal and mechanical properties are explored using machine learning interatomic potentials. The room temperature tensile strength and lattice thermal conductivity of the most stable BCN monolayer are estimated to be orientation-dependent and remarkably high, over 78 GPa and 290 W/m.K, respectively. In addition, the thermal expansion coefficient of the monolayer BCN at room temperature is estimated to be −3.2 × 10−6 K−1, which is close to that of the graphene. The piezoelectric response of the herein proposed BCN lattice is also predicted to be close to that of the h-BN monolayer. Presented results highlight outstanding physics of the BCN nanosheets.Article Citation - WoS: 8Citation - Scopus: 8Surface Microbiota and Associated Staphylococci of Houseflies (musca Domestica) Collected From Different Environmental Sources(Elsevier, 2022) Sudağıdan, Mert; Özalp, Veli Cengiz; Can, Özge; Eligül, Hakan; Yurt, Mediha Nur Zafer; Tasbasi, Behiye Busra; Acar, Elif Esma; Kavruk, Murat; Koçak, OnerHouseflies (Musca domestica) are important mechanical vectors for the transmission of pathogenic microorganisms. In this study, 129 houseflies (69 males and 60 females) were collected from 10 different environmental sources and a laboratory population was used. The surface microbiota of houseflies was identified by Next-Generation Sequencing. Staphylococci from the surfaces of houseflies were selectively isolated and their virulence genes, antibiotic susceptibilities, biofilm formation, and clonal relatedness were determined. Metagenomic analysis results demonstrated that Staphylococcus, Bacillus, and Enterococcus were mostly present on the surface of houseflies at the genus level. Additionally, the isolated 32 staphylococcal strains were identified as Staphylococcus sciuri (n = 11), S. saprophyticus (n = 9), S. arlettae (n = 6), S. xylosus (n = 4), S. epidermidis (n = 1) and S. gallinarum (n = 1). tetK, tetM, tetL, ermC, msrAB, and aad6 genes were found to carry by some of the staphylococcal strains. The strains were mostly resistant to oxacillin, penicillin, and erythromycin and three strains were multi-drug resistant. There was a statistical difference between housefly collection places and antibiotic resistance of isolated staphylococci to penicillin G, gentamicin, and erythromycin (p < 0.05). Biofilm test showed that 17 strains were strong biofilm formers, and it plays important role in the transmission of these bacteria on the surface of houseflies. Staphylococcal strains showed extracellular proteolytic and lipolytic activity in 31 and 12 strains, respectively. Closely related species were found in PFGE analysis from different environmental sources. By this study, surface microbiota and carriage of pathogenic staphylococci on the surfaces of houseflies and their virulence properties were elucidated.Article Citation - WoS: 5Citation - Scopus: 6Undescribed Polyether Ionophores From Streptomyces Cacaoi and Their Antibacterial and Antiproliferative Activities(Elsevier, 2022) Gezer, Emre; Üner, Göklem; Küçüksolak, Melis; Kurt, Mustafa Ünver; Doğan, Gamze; Ballar Kırmızıbayrak, Petek; Bedir, ErdalPolyether ionophores represent a large group of naturally occurring compounds mainly produced by Streptomyces species. With previously proven varieties of bioactivity including antibacterial, antifungal, antiparasitic, antiviral and anti-tumor effects, the discovery of undescribed polyethers leading to development of efficient therapeutics has become important. As part of our research on polyether-rich Streptomyces cacaoi, we previously performed modification studies on fermentation conditions to induce synthesis of specialized metabolites. Here, we report four undescribed and nine known polyether compounds from S. cacaoi grown in optimized conditions. Antimicrobial activity assays revealed that four compounds, including the undescribed (6), showed strong inhibitory effects over both Bacillus subtilis and methicillin-resistant Staphylococcus aureus (MRSA) growth. Additionally, K41-A and its C15-demethoxy derivative exhibited significant cytotoxicity. These results signified that selectivity of C15-demethoxy K41-A towards cancer cells was higher than K41-A, which prompted us to conduct mechanistic experiments. These studies showed that this uninvestigated compound acts as a multitarget compound by inhibiting autophagic flux, inducing reactive oxygen species formation, abolishing proteasome activity, and stimulating ER stress. Consequently, the optimized fermentation conditions of S. cacaoi led to the isolation of undescribed and known polyethers displaying promising activities.Article Citation - WoS: 30Citation - Scopus: 30Thermal Retrofitting for Sustainable Use of Traditional Dwellings in Mediterranean Climate of Southwestern Anatolia(Elsevier, 2022) Timur, Barış Ali; Başaran, Tahsin; İpekoğlu, BaşakThermal retrofitting implementations are crucial for safeguarding the functional sustainability of historical buildings as they can improve the thermal performance of these buildings while maintaining thermal comfort for their occupants. This study aims to examine the thermal behavior of a common historical building type in Anatolia / Turkey, the traditional houses with exterior hall (sofa), and to determine enhancement potentials of possible thermal interventions. Research method consists of on-site thermal measurements, laboratory analyses on traditional construction materials and transient thermal analyses utilizing simulations on DesignBuilder software. Study cases were selected from both urban and rural sub-settlements. The results demonstrated that the thermal insulation works within floor assemblies, airtightness measures, adding secondary glazing to windows and suggesting transparent circulation corridors provide significant energy improvements. These interventions would save 26.5% of building energy consumption in the urban and 30.4% in the rural sub-settlements when applied together. Furthermore, when the integration of a modern HVAC system, ground-source heat pump is implemented, these improvement rates can be increased to more than 60%. Consequently, it was determined that the cases have significant potentials for thermal enhancements which renders the application of thermal interventions as a capable conservation tool.
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