Electrical - Electronic Engineering / Elektrik - Elektronik Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/11
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Article Citation - WoS: 10Citation - Scopus: 13User Selection and Codebook Design for Noma-Based High Altitude Platform Station (haps) Communications(IEEE, 2022) Cumalı, İrem; Özbek, Berna; Karabulut Kurt, Güneş; Yanıkömeroğlu, HalimHigh altitude platform station (HAPS) communications have made a tremendous impact on recent research into sixth-generation (6G) and beyond wireless networks. The large coverage area and significant computational capability of HAPS systems enable many areas of utilization in 6G and beyond applications, including Internet of Things (IoT) services, augmented reality, and connected autonomous vehicles. In addition, non-orthogonal multiple access (NOMA) is a cutting-edge technology that can be utilized to enhance spectral efficiency in HAPS systems. In this paper, we exploit NOMA-based HAPS communications and multiple antennas to meet the connectivity, reliability, and high-data-rate requirements of 6G and beyond applications. We propose a user selection and correlation-based user pairing algorithm for a NOMA-based multi-user HAPS system. Moreover, we investigate the codebook design for HAPS communication and adapt the polar-cap codebook (PCC) to the HAPS channel which shows Rician fading propagation characteristics dominated by the line-of-sight (LOS) component. Performance evaluations show that the proposed user selection algorithm is perfectly suited to the HAPS channel and that the PCC provides a remarkable spectral efficiency.Article Citation - WoS: 3Citation - Scopus: 4Quasi-Supervised Strategies for Compound-Protein Interaction Prediction [article](Wiley-VCH Verlag, 2021) Çakı, Onur; Karaçalı, BilgeIn-silico compound-protein interaction prediction addresses prioritization of drug candidates for experimental biochemical validation because the wet-lab experiments are time-consuming, laborious and costly. Most machine learning methods proposed to that end approach this problem with supervised learning strategies in which known interactions are labeled as positive and the rest are labeled as negative. However, treating all unknown interactions as negative instances may lead to inaccuracies in real practice since some of the unknown interactions are bound to be positive interactions waiting to be identified as such. In this study, we propose to address this problem using the Quasi-Supervised Learning (QSL) algorithm. In this framework, potential interactions are predicted by estimating the overlap between a true positive dataset of compound-protein pairs with known interactions and an unknown dataset of all the remaining compound-protein pairs. The potential interactions are then identified as those in the unknown dataset that overlap with the interacting pairs in the true positive dataset in terms of the associated similarity structure. We also address the class-imbalance problem by modifying the conventional cost function of the QSL algorithm. Experimental results on GPCR and Nuclear Receptor datasets show that the proposed method can identify actual interactions from all possible combinations.Article Citation - WoS: 6Citation - Scopus: 10Surface Chemistry Dependent Toxicity of Inorganic Nanostructure Glycoconjugates on Bacterial Cells and Cancer Cell Lines(Elsevier, 2023) Sancak, Sedanur; Yazgan, İdris; Bayarslan, Aslı Uğurlu; Ayna, Adnan; Evecen, Senanur; Taşdelen, Zehra; Gümüş, Abdurrahman; Sönmez, Hamide Ayçin; Demir, Mehmet Ali; Demir, Sosin; Bakar, Fatma; Dilek Tepe, HafizeSurface functionalized nanostructures have outstanding potential in biological applications owing to their target-specific design. In this study, we utilized laboratory synthesized carbohydrate-derivatives (i.e., galactose, mannose, lactose, and cellobiose derivatives) for aqueous one-pot synthesis of gold (Au) and silver (Ag) nanostructure glycoconjugates (NSs), and iron metal-organic framework glycoconjugates (FeMOFs). This work aims to test whether differences in the surface chemistry of the inorganic nanostructures play roles in revealing their toxicities towards bacterial cells and cancerous cell lines. As of the first step, biological activity of AuNSs, AgNSs, and FeMOFs were tested against a variety of gram (−) and gram (+) bacterial strains, where AgNSs possessed moderate to high antibacterial activities against all the tested bacterial strains, while AuNSs and FeMOFs showed their bacterial toxicity mostly depending on the strain. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) determination studies were performed for the nanostructure glycoconjugates, for which μg/mL MBC values were obtained such as (Cellobiose p-aminobenzoic acid_AgNS) CBpAB_AgNS gave 50 μg/mL MBC value for P.aeruginosa and S.kentucy. The activity of selected sugar ligands and corresponding glycoconjugates were further tested on MDA-MB-231 breast cancer and A549 lung cancer cell lines, where selective anticancer activity was observed depending on the surface chemistry as well. Besides, D-penicillamine was introduced to galectin specific sugar ligand coated AuNS glycoconjugates, which showed very strong anticancer activities even at low doses. Overall, the importance of this work is that the surface chemistry of the inorganic nanostructures can be critical to reveal their toxicity towards bacterial cells and cancerous cell lines.