Electrical - Electronic Engineering / Elektrik - Elektronik Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/11
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Article Citation - WoS: 3Citation - Scopus: 3Automated Labeling of Cancer Textures in Larynx Histopathology Slides Using Quasi-Supervised Learning(Science Printers and Publishers Inc., 2014) Önder, Devrim; Sarıoğlu, Sülen; Karaçalı, BilgeOBJECTIVE: To evaluate the performance of a quasisupervised statistical learning algorithm, operating on datasets having normal and neoplastic tissues, to identify larynx squamous cell carcinomas. Furthermore, cancer texture separability measures against normal tissues are to be developed and compared either for colorectal or larynx tissues. STUDY DESIGN: Light microscopic digital images from histopathological sections were obtained from laryngectomy materials including squamous cell carcinoma and nonneoplastic regions. The texture features were calculated by using co-occurrence matrices and local histograms. The texture features were input to the quasisupervised learning algorithm. RESULTS: Larynx regions containing squamous cell carcinomas were accurately identified, having false and true positive rates up to 21% and 87%, respectively. CONCLUSION: Larynx squamous cell carcinoma versus normal tissue texture separability measures were higher than colorectal adenocarcinoma versus normal textures for the colorectal database. Furthermore, the resultant labeling performances for all larynx datasets are higher than or equal to that of colorectal datasets. The results in larynx datasets, in comparison with the former colorectal study, suggested that quasi-supervised texture classification is to be a helpful method in histopathological image classification and analysis.Article Citation - WoS: 24Citation - Scopus: 26Fiber Bragg Grating Regeneration at 450°c for Improved High Temperature Sensing(The Optical Society, 2019) Chah, Karima; Yüksel, Kıvılcım; Kinet, Damien; Yazd, Nazila Safari; Megret, Patrice; Caucheteur, ChristopheType-I fiber Bragg gratings photo-inscribed in hydrogen-loaded B/Ge co-doped silica single-mode optical fibers have been regenerated efficiently at 450 degrees C, which is the lowest temperature reported so far. The mechanical strength of the annealed fiber is preserved while ensuring temperature sensing of the regenerated gratings up to 900 degrees C. Unlike low temperature cycles (<= 600 degrees C), an annealing process at higher temperatures revealed faster regeneration for strong gratings. Changes in grating strength were also measured before the regeneration cycle. These behaviors suggest the contribution of different mechanisms to the regeneration process with different relative dynamics. (C) 2019 Optical Society of America.Article Citation - WoS: 10Citation - Scopus: 10The Effect of Additional Telerounding on Postoperative Outcomes, Patient and Surgeon Satisfaction Rates in the Patients Who Underwent Percutaneous Nephrolithotomy(Iniestares, S.A., 2019) Aydoğdu, Özgü; Şen, Volkan; Yarımoğlu, Serkan; Aydoğdu, Canan; Bozkurt, İbrahim H.; Yonguç, TarıkINTRODUCTION: We wanted to investigate the potential effect of additional telerounding system on postoperative outcomes, patient and surgeon satisfaction rates in the patients who underwent percutaneous nephrolithotomy (PNL). METHODS: Eighty patients who underwent PNL were included in the study. The patients were randomly divided to two groups. Group 1 included 40 patients who were followed-up with standard rounds and group 2 included 40 patients who were followed-up with telerounding in addition to standard rounds. Patient and surgeon satisfaction rates were assessed with a visual analog scale (VAS) where 0 point represents very dissatisfied and 100 points very satisfied. RESULTS: Mean time of preoperative telerounding visit was 3.65 +/- 0.59 (2-4) minutes. Mean time of telerounding visits on the postoperative 1st and 2nd days was 3.80 +/- 0.62 and 2.9 +/- 0.91 minutes respectively. The VAS score evaluating the surgeon's satisfaction rate for telerounding was 91 +/- 11.2 and patients expressed a high level of satisfaction with 72.5%. CONCLUSION: The use of additional telerounding in urological patient care provides high satisfaction rates for both the patients and the surgeon. However the findings of the present study don't underestimate the importance of personal surgeon-patient interaction.Article Citation - WoS: 19Citation - Scopus: 21Spectral Shadowing Suppression Technique in Phase-Otdr Sensing Based on Weak Fiber Bragg Grating Array(The Optical Society, 2019) de Miguel Soto, Veronica; Jason, Johan; Kurtoğlu, Deniz; Lopez-Amo, Manuel; Wuilpart, MarcA postprocessing procedure is presented to suppress spectral shadowing in phase-OTDR sensing systems based on a weak fiber Bragg grating array. A complete theoretical analysis of the interfering signals has been carried out to identify a compensation method. The proposed approach has been applied to simulated and experimental phase-OTDR in the context of vibration measurements. Fast Fourier transform has been employed to analyze the obtained results, which has verified the validity of the proposed method to suppress spectral shadowing. (C) 2019 Optical Society of AmericaArticle Citation - WoS: 18Citation - Scopus: 19Generalized Bayesian Model Selection for Speckle on Remote Sensing Images(Institute of Electrical and Electronics Engineers Inc., 2019) Karakuş, Oktay; Kuruoğlu, Ercan E.; Altınkaya, Mustafa AzizSynthetic aperture radar (SAR) and ultrasound (US) are two important active imaging techniques for remote sensing, both of which are subject to speckle noise caused by coherent summation of back-scattered waves and subsequent nonlinear envelope transformations. Estimating the characteristics of this multiplicative noise is crucial to develop denoising methods and to improve statistical inference from remote sensing images. In this paper, reversible jump Markov chain Monte Carlo (RJMCMC) algorithm has been used with a wider interpretation and a recently proposed RJMCMC-based Bayesian approach, trans-space RJMCMC, has been utilized. The proposed method provides an automatic model class selection mechanism for remote sensing images of SAR and US where the model class space consists of popular envelope distribution families. The proposed method estimates the correct distribution family, as well as the shape and the scale parameters, avoiding performing an exhaustive search. For the experimental analysis, different SAR images of urban, forest and agricultural scenes, and two different US images of a human heart have been used. Simulation results show the efficiency of the proposed method in finding statistical models for speckle.Article Citation - WoS: 14Citation - Scopus: 18Separating Normosmic and Anosmic Patients Based on Entropy Evaluation of Olfactory Event-Related Potentials(Elsevier Ltd., 2019) Güdücü, Çağdaş; Olcay, Bilal Orkan; Schaefer, L.; Aziz, M.; Schriever, V. A.; Özgören, Murat; Hummel, T.Objective: Methods based on electroencephalography (EEG) are used to evaluate brain responses to odors which is challenging due to the relatively low signal-to-noise ratio. This is especially difficult in patients with olfactory loss. In the present study, we aim to establish a method to separate functionally anosmic and normosmic individuals by means of recordings of olfactory event-related potentials (OERP) using an automated tool. Therefore, Shannon entropy was adopted to examine the complexity of the averaged electrophysiological responses. Methods: A total of 102 participants received 60 rose-like odorous stimuli at an inter-stimulus interval of 10 s. Olfactory-related brain activity was investigated within three time-windows of equal length; pre-, during-, and post-stimulus. Results: Based on entropy analysis, patients were correctly diagnosed for anosmia with a 75% success rate. Conclusion: This novel approach can be expected to help clinicians to identify patients with anosmia or patients with early symptoms of neurodegenerative disorders. Significance: There is no automated diagnostic tool for anosmic and normosmic patients using OERP. However, detectability of OERP in patients with functional anosmia has been reported to be in the range of 50%.Article Citation - WoS: 14Citation - Scopus: 17Evaluation of Synchronization Measures for Capturing the Lagged Synchronization Between Eeg Channels: a Cognitive Task Recognition Approach(Elsevier, 2019) Olcay, Bilal Orkan; Karaçalı, BilgeDuring cognitive, perceptual and sensory tasks, connectivity profile changes across different regions of the brain. Variations of such connectivity patterns between different cognitive tasks can be evaluated using pairwise synchronization measures applied to electrophysiological signals, such as electroencephalography (EEG). However, connectivity-based task recognition approaches achieving viable recognition performance have been lacking from the literature. By using several synchronization measures, we identify time lags between channel pairs during different cognitive tasks. We employed mutual information, cross correntropy, cross correlation, phase locking value, cosine similarity and nonlinear interdependence measures. In the training phase, for each type of cognitive task, we identify the time lags that maximize the average synchronization between channel pairs. These lags are used to calculate pairwise synchronization values with which we construct the train and test feature vectors for recognition of the cognitive task carried out using Fisher's linear discriminant (FLD) analysis. We tested our framework in a motor imagery activity recognition scenario on PhysioNet Motor Movement/Imagery and BCI Competition-III IVa datasets. For PhysioNet dataset, average performance results ranging between % 51 and % 61 across 20 subjects. For BCI Competition-III dataset, we achieve an average recognition performance of % 76 which is above the minimum reliable communication rate (% 70). We achieved an average accuracy over the minimum reliable communication rate on the BCI Competition-III dataset. Performance levels were lower on the PhysioNet dataset. These results indicate that a viable task recognition system is achievable using pairwise synchronization measures evaluated at the proper task specific lags.Article Citation - WoS: 59Citation - Scopus: 57Cmos Enabled Microfluidic Systems for Healthcare Based Applications(John Wiley and Sons Inc., 2018) Hussian, Muhammad M.; Khan, Sherjeel M.; Gümüş, Abdurrahman; Nassar, Joanna M.With the increased global population, it is more important than ever to expand accessibility to affordable personalized healthcare. In this context, a seamless integration of microfluidic technology for bioanalysis and drug delivery and complementary metal oxide semiconductor (CMOS) technology enabled data-management circuitry is critical. Therefore, here, the fundamentals, integration aspects, and applications of CMOS-enabled microfluidic systems for affordable personalized healthcare systems are presented. Critical components, like sensors, actuators, and their fabrication and packaging, are discussed and reviewed in detail. With the emergence of the Internet-of-Things and the upcoming Internet-of-Everything for a people–process–data–device connected world, now is the time to take CMOS-enabled microfluidics technology to as many people as possible. There is enormous potential for microfluidic technologies in affordable healthcare for everyone, and CMOS technology will play a major role in making that happen.Article Citation - WoS: 560Citation - Scopus: 607A Community Effort To Assess and Improve Drug Sensitivity Prediction Algorithms(Nature Publishing Group, 2014) Costello, James C.; Heiser, Laura M.; Georgii, Elisabeth; Gönen, Mehmet; Menden, Michael P.; Wang, Nicholas J.; Bansal, Mukesh; Ammad-ud-din, Muhammad; Hintsanen, Petteri; Khan, Suleiman A.; Mpindi, John-Patrick; Kallioniemi, Olli; Honkela, Antti; Aittokallio, Tero; Wennerberg, Krister; NCI-DREAM Community; Karaçalı, Bilge; Collins, James J.; Gallahan, Dan; Singer, Dinah; Saez-Rodriguez, Julio; Kaski, Samuel; Gray, Joe W.; Stolovitzky, GustavoPredicting the best treatment strategy from genomic information is a core goal of precision medicine. Here we focus on predicting drug response based on a cohort of genomic, epigenomic and proteomic profiling data sets measured in human breast cancer cell lines. Through a collaborative effort between the National Cancer Institute (NCI) and the Dialogue on Reverse Engineering Assessment and Methods (DREAM) project, we analyzed a total of 44 drug sensitivity prediction algorithms. The top-performing approaches modeled nonlinear relationships and incorporated biological pathway information. We found that gene expression microarrays consistently provided the best predictive power of the individual profiling data sets; however, performance was increased by including multiple, independent data sets. We discuss the innovations underlying the top-performing methodology, Bayesian multitask MKL, and we provide detailed descriptions of all methods. This study establishes benchmarks for drug sensitivity prediction and identifies approaches that can be leveraged for the development of new methods.Article Citation - WoS: 240Citation - Scopus: 264A Community Computational Challenge To Predict the Activity of Pairs of Compounds(Nature Publishing Group, 2014) Bansal, Mukesh; Yang, Jichen; Karan, Charles; Menden, Michael P.; Costello, James C.; Tang, Hao; Xiao, Guanghua; Li, Yajuan; Allen, Jeffrey; Zhong, Rui; Chen, Beibei; Kim, Minsoo; Wang, Tao; Heiser, Laura M.; Realubit, Ronald; Mattioli, Michela; Alvarez, Mariano J.; Shen, Yao; NCI-DREAM Community; Karaçalı, Bilge; Gallahan, Daniel; Singer, Dinah; Saez-Rodriguez, Julio; Xie, Yang; Stolovitzky, Gustavo; Califano, AndreaRecent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers of synergistic combinations. The DREAM consortium launched an open challenge to foster the development of in silico methods to computationally rank 91 compound pairs, from the most synergistic to the most antagonistic, based on gene-expression profiles of human B cells treated with individual compounds at multiple time points and concentrations. Using scoring metrics based on experimental dose-response curves, we assessed 32 methods (31 community-generated approaches and SynGen), four of which performed significantly better than random guessing. We highlight similarities between the methods. Although the accuracy of predictions was not optimal, we find that computational prediction of compound-pair activity is possible, and that community challenges can be useful to advance the field of in silico compound-synergy prediction.