Chemistry / Kimya

Permanent URI for this collectionhttps://hdl.handle.net/11147/4072

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Access Right: Open AccessSubject: search.filters.subject.Mass spectrometry

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  • Book Part
    Citation - Scopus: 1
    Mass Spectroscopy in Polymer Research
    (John Wiley and Sons Inc., 2012) Hacaloğlu, Jale; Yalçın, Talat; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
    Mass spectrometers are currently available in numerous confi gurations with various ionization techniques and mass analyzers. For a specifi c polymer sample, an optimal choice should be done depending on the information sought. In practice, no single mass spectrometric technique can provide all necessary information for structural, compositional, and thermal and oxidative degradation characteristics of polymeric samples. The analyzer used determines the limits of the sensitivity and resolution and the mass range, whereas the type of ionization source specifi es the information that can be gained.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Changes in Protein Profiles of Multiple Myeloma Cells in Response To Bortezomib
    (Informa Healthcare, 2013) Turan, Taylan; Şanlı Mohamed, Gülşah; Şanlı Mohamed, Gülşah; Baran, Yusuf; 04.03. Department of Molecular Biology and Genetics; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
    The objective of this study was to determine the changes in protein profiles of U-266 multiple myeloma cells in response to bortezomib. Bortezomib inhibited cell proliferation and increased the loss of mitochondrial membrane potential and caspase-3 activity in a dose-dependent manner. DECODON Delta2D Version 4.3 software demonstrated 37 differentially expressed protein spots: five proteins were newly formed, 10 proteins were lost, 12 proteins were up-regulated and 10 proteins were down-regulated in bortezomib-treated cells as compared to untreated cells. Some of the identified proteins after mass spectrometric analysis were as follows: apoptosis regulatory protein Siva (newly formed), caspase recruitment domain-containing protein 14 (lost), Ras-related protein Rab-25 (up-regulated), nuclear factor κB (NF-κB) p105 subunit (down-regulated). In summary, differentially expressed proteins of MM U-266 cells in response to bortezomib were analyzed and identified. The data obtained from this study may indicate the use of bortezomib for the treatment of various diseases.