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Semi-Synthetic Studies on Astragaloside Vii and Immunomodulatory Activities of the Derivatives
(Georg Thieme Verlag, 2019) Yakuboğulları, Nilgün; Sağ, Duygu; Çağır, Ali; Bedir, Erdal
Adjuvants have been used in vaccine sector since 1920s to increase the immunogenicity of antigens, reduce the dosage and minimize frequency of immunizations [1]. The use of saponins as adjuvant in the prophylactic/therapeutic human and veterinary vaccines, and investigation of their immunomodulatory activities have gained importance in recent years [2],[3]. Astragaloside VII (AST VII), a triterpenoid saponin isolated from Astragalus species, stimulates Th1 mediated immune response, antigen-specific antibody response and splenocyte proliferation.
Citation - WoS: 7
Citation - Scopus: 7
Cleavage of Ring a and Formation of an Unusual Nor-Triterpene Skeleton Via the Baeyer-Villiger Reaction
(Elsevier Ltd., 2012) Tağ, Özgür; Çağır, Ali; Khan, Ikhlas A.; Bedir, Erdal
With the aim to generate a compound library for our biological screening studies, cycloastragenol was subjected to chemical transformation studies. The Baeyer-Villiger oxidation experiments provided an interesting 3,5-seco-4-nor-triterpene skeleton via ring opening followed by an unusual rearrangement. A new methodology is described for transforming triterpenoids into 3,5-seco-4-nor derivatives.

Chemistry / Kimya