Chemistry / Kimya

Permanent URI for this collectionhttps://hdl.handle.net/11147/4072

Browse

Filters

Settings

Author: search.filters.author.Polat, HürriyetLanguage: search.filters.language.en

Search Results

Now showing 1 - 10 of 28
  • Article
    Citation - WoS: 2
    Citation - Scopus: 3
    A Phenomenological Kinetic Flotation Model: Distinct Time-Variant Floatability Distributions for the Pulp and Froth Materials
    (Elsevier, 2023) Polat, Mehmet; Polat, Hürriyet
    A simple and easy-to-use phenomenological kinetic flotation model, strongly connected with the physics of the process, is proposed in this paper. The model explicitly contains the cell volume, aeration rate, volumetric holdup, mean bubble size, and particle density as input variables. It can be employed to characterize the floatability distributions of the particles in the pulp and the froth separately any time during the flotation process. Two new time-dependent kinetic parameters, the bubble loading factor & phi;(t) and the maximum cell mass transfer capacity Mmax(t) also appear in the model expression. & phi;(t) is a measure of the degree of crowding of the bubble surfaces and accounts for the deviations from the first-order rate equation. Mmax(t) describes the maximum amount of mass that can be transported to the froth phase by the bubble population in the cell. Screen fractionation of each froth product collected at different time intervals during a single kinetic flotation test is sufficient to generate the data required by the model for analysis. Application of the model to this data yields directly time-dependent functions for the floatability of the particles reporting to froth Kf(t) or remaining in the cell Kp(t) for each size fraction separately, without the need for any empirical parameters. The test of the model was carried out using published kinetic flotation data from the literature.
  • Book Part
    Citation - Scopus: 3
    Tissue Engineering Applications of Marine-Based Materials
    (Springer, 2022) Polat, Hürriyet; Zeybek, Nuket; Polat, Mehmet
    Tissue engineering is a promising approach in replacing or improving tissues lost or has become nonviable due to disease or trauma by the use of scaffold materials by combining engineering and biochemical/physicochemical methods. Its purpose is to create suitable matrices that support cell differentiation and proliferation toward the formation of new and functional tissue. Marine-based natural compounds are potential scaffold feedstock material in tissue engineering owing to their biocompatibility and biodegradability while providing excellent biochemical/physicochemical properties. Numerous application areas and various fabrication routes techniques described in the literature attest to the importance of these materials in tissue regeneration. This review has been carried to merge the information from a large number of studies on the marine-based scaffold materials in tissue engineering into a coherent summary. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 11
    The Effect of Protein Bsa on the Stability of Lipophilic Drug (docetaxel)-Loaded Polymeric Micelles
    (Elsevier, 2021) Polat, Hürriyet; Çevik Eren, Merve; Polat, Mehmet
    Polymeric micelles are promising delivery vehicles for improving the efficacy of anticancer drugs and reducing their side effects. However, considering the binding ability of serum albumin, the possible interaction of micelles with the native plasma components in the bloodstream raises serious questions on micellar stability. The stability of barren or drug-loaded copolymeric micelles was investigated systematically in distilled water (DW) and simulated body fluid (SBF) solutions in the presence of a model protein. The copolymer was a Pluronic® series triblock copolymer (P-123), the drug was strongly lipophilic docetaxel (DOC) and the protein was Bovine Serum Albumin (BSA). The effect of such factors as BSA and DOC concentrations and the aging of the micellar solutions was studied. Both the barren and drug-loaded micelles were quite stable in blank DW and SBF solutions for long times up to 10 days. They lost integrity and showed no inclination to re-assemble when the BSA concentration reached a critical value, which was very close to the plasma Human Serum Albumin (HSA) concentration. The presence of DOC in the micellar cores could not prevent disintegration. The results illustrate clearly that ensuring the stability of polymeric micelles in blood plasma should be an important design factor in their use as drug carriers.
  • Conference Object
    Effect of Some Physical, and Chemical Variables on Flocculation and Sediment Behaviour
    (A.A. Balkema Publishers, 2000) Polat, Hürriyet; Polat, Mehmet; İpekoğlu, Üner
    Effect of some chemical and physical variables on the settling rate, final sediment height, sediment viscosity and supernatant turbidity of a clay sample was studied using various polyacrylamide type flocculants. Increasing flocculant concentration significantly increased both the settling rate and sediment viscosity. More importantly, changes in the final sediment, height, hence the packing density, was minimal for all the conditions tested once the sediment was allowed to consolidate. Also, the mode of addition of the polymer, at once or continuous, did not seem to affect any of the parameters measured. Conditioning time seemed to alter the settling rate at low polymer concentrations, but had no effect at high polymer concentrations. However, increasing the conditioning time caused a decrease in the sediment viscosity. Different types of the polyacrylimides generated different settling rates at a given concentration, but the final sediment height was nearly independent of polymer type.
  • Conference Object
    Use of Ion Flotation To Remove Copper From Waste Waters
    (2006) Erdoğan, Demet; Polat, Hürriyet; İpekoğlu, Üner
    Flotation studies were carried out to investigate the removal of copper from wastewaters. Various parameters such as pH, surfactant and frother concentrations and airflow rate were tested to determine the optimum flotation conditions. Sodium dodecyl sulfate and Hexadecyltrimethyl ammonium bromide were used as collectors. Recoveries as high as 90% could be to obtained under optimum conditions.
  • Book Part
    Citation - Scopus: 6
    Recent Advances in Chitosan-Based Systems for Delivery of Anticancer Drugs
    (Springer, 2020) Polat, Mehmet; Polat, Hürriyet
    Problems in transporting drug molecules to tumor sites in required dose or constitution lead to low efficacy and significant side effects. Shielding the drug molecules in micelles, liposomes, or nanoparticles is a major line of investigation to improve chemotherapeutic treatment. Though compatibility for proper envelopment of the drug and timely release at the tumor site are required of such a carrier, protecting its own physicochemical and morphological integrity during transport is another precondition. Because of its superior polymerization capability, biocompatibility, pH dependence, and charging characteristics, chitosan has been in the forefront of potential drug carriers. Numerous synthesis routes for chitosan-based nanocarriers have been suggested to the extent that a search of the literature published since 2000 with the keywords “novel + nano + chitosan” in the title results in 527 articles, indicating the bewildering quality and quantity of the new information. This review was carried out not only to peruse this large amount of work on chitosan-based anticancer drug delivery but also to extract manageable patterns from numerous synthesis routes. The main conclusion is that the synthesis methods suggested in literature can be combined into two main routes, and the degree of hydrophobicity of the drug determines which route should be followed. © Springer Nature Singapore Pte Ltd. 2019.
  • Article
    Citation - WoS: 2
    Reduction of Carbon Dioxide During the Synthesis of Metal Nano-Particles in Water
    (Elsevier Ltd., 2003) Polat, Hürriyet; Cohen, H; Meyerstein, D; Rusonik, I.
    An effort was made to synthesize "carbon-free" metal (Fe-0, Co-0, Ni-0) nano-particles via the reduction of their salts with BH4- in aqueous solutions. Surprisingly it was found that when the synthesis is carried out in the presence of CO2, e.g., in aerated solutions, the CO2 is catalytically reduced by BH(4)(-)on the surface of the metal particles. Carbon-free metals can be prepared by reduction under an inert atmosphere. Thus metal surfaces might have acted as catalysts for CO2 fixation, probably via the initial formation of carbon clusters, in the reductive atmosphere in the prebiotic era. (C) 2003 Elsevier B.V. All rights reserved.
  • Correction
    Erratum To: Tannery Wastewater Sediments Produced by Clinoptiolite/Polyacrylamide-aided Flocculation as a Clay Additive in Brick Making
    (Australian Ceramic Society, 2017) Israil, L. I.; Köseoğlu, Kemal; Cengizler, H.; Polat, Hürriyet
    [No abstract available]
  • Article
    Citation - WoS: 13
    Citation - Scopus: 15
    Analysis of Dilution Induced Disintegration of Micellar Drug Carriers in the Presence of Inter and Intra Micellar Species
    (Elsevier, 2020) Polat, Hürriyet; Kutluay, Gülistan; Polat, Mehmet
    Micelles of self-assembling polymeric surfactant molecules are promising nanoscopic carriers for lipophilic and toxic drugs, genes, and imaging molecules. Though it is a must for successful transport, ensuring micelle integrity is a challenge during intravenous injection where micelles must endure abrupt dilutional effects and encounters with native molecules. Therefore, direct observational evidence of how micelles behave during dilution is valuable in manipulating the designs of these carriers for a succesful drug delivery. Morphology and stability of the barren and a drug-loaded (lipophilic probucol) micelles of a polymeric surfactant (Pluronic® P123) were monitored during systematic re-dilution in distilled water and simulated body fluid in the presence of a model protein (bovine serum albumin). It was observed through surface tension, dynamic light scattering, laser velocimetry, transmission scanning and transmission electron microscopy, and atomic force microscopy analyses that the micelles disintegrated to various degrees in all cases upon dilution. The results indicate that dilution effects must be taken into account in designing micellar drug carriers. The assistance of some other means of protection such as encapsulation should be considered for ensuring micelle integrity within the bloodstream. © 2020 Elsevier B.V.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Tannery Wastewater Sediments Produced by Clinoptiolite/Polyacrylamide-aided Flocculation as a Clay Additive in Brick Making
    (Springer Verlag, 2017) Köseoğlu, Kemal; Cengizler, H.; İsrail, L. İ.; Polat, Hürriyet
    Toxic tannery wastewater(s) (TWW) pose(s) a great risk to the environment. This study explores the potential of mitigating the harmful effects of TWW through sedimentation using clinoptiolite in the presence of various anionic, cationic and non-ionic flocculants with different molecular weights and charge densities followed by encapsulation in a brick structure for stability. Compressive strength (CS), size reduction after firing (SRAF), water absorption (WA) and colouring parameters of bricks were determined. X-Ray diffraction (XRD) and scanning electron microscopy (SEM)-energy dispersive X-ray (EDX) analyses were conducted on brick bodies. Kinetic leaching experiments were conducted for possible heavy metal release from the bricks. Bricks containing 10 wt% leather waste and 5 wt% clinoptiolite sintered at 800 °C instead of 920 °C possessed similar properties to the standard brick (SB).