Chemistry / Kimya

Permanent URI for this collectionhttps://hdl.handle.net/11147/4072

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Now showing 1 - 5 of 5
  • Book Part
    Citation - Scopus: 3
    Tissue Engineering Applications of Marine-Based Materials
    (Springer, 2022) Polat, Hürriyet; Zeybek, Nuket; Polat, Mehmet
    Tissue engineering is a promising approach in replacing or improving tissues lost or has become nonviable due to disease or trauma by the use of scaffold materials by combining engineering and biochemical/physicochemical methods. Its purpose is to create suitable matrices that support cell differentiation and proliferation toward the formation of new and functional tissue. Marine-based natural compounds are potential scaffold feedstock material in tissue engineering owing to their biocompatibility and biodegradability while providing excellent biochemical/physicochemical properties. Numerous application areas and various fabrication routes techniques described in the literature attest to the importance of these materials in tissue regeneration. This review has been carried to merge the information from a large number of studies on the marine-based scaffold materials in tissue engineering into a coherent summary. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
  • Research Project
    Uçucu kül ve doğal zeolitin beraber kullanılarak borun atık sulardan uzaklaştırılması
    (2008) Polat, Hürriyet; Polat, Mehmet; Şekeroğlu, Koray
    Bu proje kapsamında, Yeniköy, Kemerköy, Soma ve Yatağan termik santrallerinden alınan uçucu küllerin, sıcaklık, katı / sıvı oranı ve başlangıç konsantrasyonu gibi parametler kullanılarak bor adsorpsiyon kapasiteleri incelenmiştir. Bor adsorpsiyon deneyleri laboratuvarda hazırlanan simültane sular (10, 25, 50, 100 ve 300 ppm Bor) ve Kızıldere (Denizli) jeotermal tesislerinden (25-30 ppm Bor) alınan borlu sularla yapılmıştır. Yapılan “batch” deneylere dayanarak, uçucu küllerin boru adsopladığı ve özellikle yüzey alanı en geniş olan Yeniköy külü yeterli zaman ve yüzey alanı sağlandığında %99 ‘a varan adsorpsiyon miktarına ulaştığı gözlenmiştir. Tüm küllerin deney sonuçları tek katmanlı adsorpsiyonu belirten “Langmuir” izotermine ve Kaydırılmış İkinci Mertebe parametresine daha uygun olduğu tespit edilmiştir. Yapılan sıcaklık çalışmalarında, Yeniköy ve Kemerköy külleriyle 25o C, 45o C ve 65o C koşullarında yapılan deneylerin verileri kullanılarak, o ΔH ,o ΔG , o ΔS değerleri hesaplanmıştır. Sıcaklıkla azalan adsorpsiyon kapasitesi ve negatif o ΔH değerleri, ekzotermik adsorpsiyon olduğunu belirtmektedir. Aynı zamanda -40,0 kJ / mol’ün altında çıkan (-52,89 ve -48,55 kJ / mol) entalpi ( o ΔH ) değerleri kimyasal adsorpsiyon olduğunu belirtmektedir. Soma ve Yatağan külleri için de Langmuir izotermlerinin uygun olması kimyasal bir adsorpsiyon olduğunu önermektedir.
  • Article
    Solunabilir Tozun Su Spreyleri Kullanılarak Bastırılmasında Son Gelişmeler
    (2000) Polat, Hürriyet; Polat, Mehmet; Gürgen, Sabit
    Türkiye'de görülen meslek hastalıklarının çoğunu tozun solunmasından kaynaklanan pnömokonyoz oluşturmaktadır. Bu yazının amacı, yeraltı ocaklarında işçi sağlığı açısından sakıncalı olan havada asılı tozların, su spreyleri kullanılarak bastırılması konusunda gelinen aşamayı sunmaktır. Bu amaçla, havada asılı toz ve su damlalarıyla yapılan detaylı çalışmalar ışığında, sprey suyuna katılan yüzey aktif maddelerin istenen verim artışını sağlayamama nedenleri ele alınmakta ve su spreylerinin Türkiye'deki maden ocaklarında kullanım olanakları tartışılmaktadır.
  • Conference Object
    Effect of Some Physical, and Chemical Variables on Flocculation and Sediment Behaviour
    (A.A. Balkema Publishers, 2000) Polat, Hürriyet; Polat, Mehmet; İpekoğlu, Üner
    Effect of some chemical and physical variables on the settling rate, final sediment height, sediment viscosity and supernatant turbidity of a clay sample was studied using various polyacrylamide type flocculants. Increasing flocculant concentration significantly increased both the settling rate and sediment viscosity. More importantly, changes in the final sediment, height, hence the packing density, was minimal for all the conditions tested once the sediment was allowed to consolidate. Also, the mode of addition of the polymer, at once or continuous, did not seem to affect any of the parameters measured. Conditioning time seemed to alter the settling rate at low polymer concentrations, but had no effect at high polymer concentrations. However, increasing the conditioning time caused a decrease in the sediment viscosity. Different types of the polyacrylimides generated different settling rates at a given concentration, but the final sediment height was nearly independent of polymer type.
  • Book Part
    Citation - Scopus: 6
    Recent Advances in Chitosan-Based Systems for Delivery of Anticancer Drugs
    (Springer, 2020) Polat, Mehmet; Polat, Hürriyet
    Problems in transporting drug molecules to tumor sites in required dose or constitution lead to low efficacy and significant side effects. Shielding the drug molecules in micelles, liposomes, or nanoparticles is a major line of investigation to improve chemotherapeutic treatment. Though compatibility for proper envelopment of the drug and timely release at the tumor site are required of such a carrier, protecting its own physicochemical and morphological integrity during transport is another precondition. Because of its superior polymerization capability, biocompatibility, pH dependence, and charging characteristics, chitosan has been in the forefront of potential drug carriers. Numerous synthesis routes for chitosan-based nanocarriers have been suggested to the extent that a search of the literature published since 2000 with the keywords “novel + nano + chitosan” in the title results in 527 articles, indicating the bewildering quality and quantity of the new information. This review was carried out not only to peruse this large amount of work on chitosan-based anticancer drug delivery but also to extract manageable patterns from numerous synthesis routes. The main conclusion is that the synthesis methods suggested in literature can be combined into two main routes, and the degree of hydrophobicity of the drug determines which route should be followed. © Springer Nature Singapore Pte Ltd. 2019.