Çömlekçi, Yiğit Ege

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https://hdl.handle.net/11147/16104
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Main Affiliation
01. Izmir Institute of Technology
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WoS Researcher ID

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
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GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
2
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QUALITY EDUCATION4
QUALITY EDUCATION
0
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GENDER EQUALITY5
GENDER EQUALITY
0
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CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
0
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AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
0
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DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
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INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
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REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
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SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
0
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RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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CLIMATE ACTION13
CLIMATE ACTION
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LIFE BELOW WATER14
LIFE BELOW WATER
0
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LIFE ON LAND15
LIFE ON LAND
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
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PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
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Scholarly Output

2

Articles

1

Views / Downloads

4804/548

Supervised MSc Theses

1

Supervised PhD Theses

0

WoS Citation Count

5

Scopus Citation Count

7

Patents

0

Projects

0

WoS Citations per Publication

2.50

Scopus Citations per Publication

3.50

Open Access Source

1

Supervised Theses

1

JournalCount
Phytochemistry Letters1
Current Page: 1 / 1

Scopus Quartile Distribution

Competency Cloud

GCRIS Competency Cloud
Author of Publication: search.filters.isAuthorOfPublication.27557317-e5ea-4723-a7f2-ae6896e9fe25

Scholarly Output Search Results

Now showing 1 - 2 of 2
  • Master Thesis
    Docking Studies on Selected Sapogenins Targeting Androgen and Estrogen Receptors
    (01. Izmir Institute of Technology, 2021) Bedir, Erdal; Çömlekçi, Yiğit Ege; Bedir, Erdal; 01. Izmir Institute of Technology; 03.01. Department of Bioengineering; 03. Faculty of Engineering
    Natural products have been used in the treatment of various diseases in history, and they are still in use today. Sapogenins are natural products derived from plant and animal sources that also have numerous biological activities. Furthermore, some sapogenins have been found to be active in common cancers such as prostate and estrogen alpha-mediated breast cancer and exert their effects via the androgen and estrogen receptors. For this reason, identifying alternative ligands for these receptors may aid in enhancing the benefits or avoiding adverse effects. Traditional or advanced molecular screening techniques are available with their respective applications. However, these applications have some limitations, such as being complicated and costly or requiring a significant amount of time due to the large number of molecules involved. With advancements in technology, in-silico methods such as molecular docking have developed into a highly accurate and cost-effective method for high throughput screening. Additionally, rapid and high-quality in-silico visualization of docked ligands and their interactions serves as a preliminary step toward determining structure-activity relationships. The molecular docking method was used in this study to identify novel androgen and estrogen receptor ligands, and to evaluate the structure-activity relationship of sapogenin molecules, which were selected from our research group's molecule library. Moreover, the Swiss Target Prediction web service was used to determine the probability of bindings prior to molecular docking. The molecular docking results demonstrated that nine of the selected sapogenins were more bindable to the androgen receptor than testosterone, whereas another nine were found to be more bindable to the estrogen receptor than estradiol. Additionally, immunoblotting was utilized to validate the activity of several molecules by examining their effects on PSA levels for androgen receptor binding.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 7
    Five New Cardenolides Transformed From Oleandrin and Nerigoside by Alternaria Eureka 1e1bl1 and Phaeosphaeriasp. 1e4cs-1 and Their Cytotoxic Activities
    (Elsevier Ltd., 2021) Karakoyun, Çiğdem; Bedir, Erdal; Küçüksolak, Melis; Çömlekçi, Yiğit Ege; Bilgi, Eyüp; Bilgi, Eyüp; Doğan, Gamze; Küçüksolak, Melis; Çömlekçi, Yiğit Ege; Bedir, Erdal; 03.01. Department of Bioengineering; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    Biotransformation of oleandrin (1) and nerigoside (2) by endophytic fungi; Alternaria eureka 1E1BL1 and Phaeospheria sp. 1E4CS-1, has led to the isolation of five new metabolites (3, 5, 6, 7 and 8) together with a known compound (4). The structures of the biotransformation products were elucidated by 1D-, 2D NMR and HR-MS. Phaeospheria sp. mainly provided monooxygenation reactions on the A and B rings, whereas A. eureka afforded both monooxygenated and desacetylated derivatives of the substrates. Cytotoxic activity of the compounds was tested against a non-cancerous (HEK-293) and four cancer (PANC-1, MIA PaCa-2, DU 145 and A549) cell lines by MTT cell viability assay. All compounds were less cytotoxic than oleandrin, which had IC50 values ranging between 2.7 and 41.9 nM. Two of the monohydroxylated metabolites, viz. 7(?)-hydroxy oleandrin (3) and 1(?)-hydroxy oleandrin (7), were also potent with IC50 values from 18.45 to 39.0 nM, while desacetylated + monohydroxylated, or dihydroxylated products had much lower cytotoxicity. Additionally, the lesser activity of 2 and its metabolite (6) possessing diginose as sugar residue inferred that oleandrose moiety is important for the toxicity of oleandrin as well as hydrophobicity of the steroid core. © 2020 Phytochemical Society of Europe