Can, Özge

Profile URL
https://hdl.handle.net/11147/16221
Name Variants
Can, O
Can, Ozge
Can, Ö.
Can, Ö
Can, O.
Job Title
Email Address
ocan@iyte.edu.tr
Main Affiliation
03.01. Department of Bioengineering
Status
Current Staff
Website
ORCID ID
0000-0002-3203-645X
Scopus Author ID
57443615500
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
GLN-7377-2022

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
Research Products
GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
1
Research Products
QUALITY EDUCATION4
QUALITY EDUCATION
0
Research Products
GENDER EQUALITY5
GENDER EQUALITY
0
Research Products
CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
2
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
1
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
2
Research Products
REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
Research Products
SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
1
Research Products
RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
1
Research Products
CLIMATE ACTION13
CLIMATE ACTION
1
Research Products
LIFE BELOW WATER14
LIFE BELOW WATER
0
Research Products
LIFE ON LAND15
LIFE ON LAND
0
Research Products
PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
Research Products
Documents

22

Citations

88

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Documents

3

Citations

18

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Scholarly Output

7

Articles

4

Views / Downloads

17389/4710

Supervised MSc Theses

2

Supervised PhD Theses

0

WoS Citation Count

53

Scopus Citation Count

59

Patents

0

Projects

0

WoS Citations per Publication

7.57

Scopus Citations per Publication

8.43

Open Access Source

6

Supervised Theses

2

JournalCount
Desalination1
Journal of Microbiology Biotechnology and Food Sciences1
Macromolecular Bioscience1
Microbial Pathogenesis1
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Scholarly Output Search Results

Now showing 1 - 7 of 7
  • Article
    Citation - WoS: 8
    Citation - Scopus: 8
    Surface Microbiota and Associated Staphylococci of Houseflies (musca Domestica) Collected From Different Environmental Sources
    (Elsevier, 2022) Sudağıdan, Mert; Özalp, Veli Cengiz; Can, Özge; Eligül, Hakan; Yurt, Mediha Nur Zafer; Tasbasi, Behiye Busra; Acar, Elif Esma; Kavruk, Murat; Koçak, Oner
    Houseflies (Musca domestica) are important mechanical vectors for the transmission of pathogenic microorganisms. In this study, 129 houseflies (69 males and 60 females) were collected from 10 different environmental sources and a laboratory population was used. The surface microbiota of houseflies was identified by Next-Generation Sequencing. Staphylococci from the surfaces of houseflies were selectively isolated and their virulence genes, antibiotic susceptibilities, biofilm formation, and clonal relatedness were determined. Metagenomic analysis results demonstrated that Staphylococcus, Bacillus, and Enterococcus were mostly present on the surface of houseflies at the genus level. Additionally, the isolated 32 staphylococcal strains were identified as Staphylococcus sciuri (n = 11), S. saprophyticus (n = 9), S. arlettae (n = 6), S. xylosus (n = 4), S. epidermidis (n = 1) and S. gallinarum (n = 1). tetK, tetM, tetL, ermC, msrAB, and aad6 genes were found to carry by some of the staphylococcal strains. The strains were mostly resistant to oxacillin, penicillin, and erythromycin and three strains were multi-drug resistant. There was a statistical difference between housefly collection places and antibiotic resistance of isolated staphylococci to penicillin G, gentamicin, and erythromycin (p < 0.05). Biofilm test showed that 17 strains were strong biofilm formers, and it plays important role in the transmission of these bacteria on the surface of houseflies. Staphylococcal strains showed extracellular proteolytic and lipolytic activity in 31 and 12 strains, respectively. Closely related species were found in PFGE analysis from different environmental sources. By this study, surface microbiota and carriage of pathogenic staphylococci on the surfaces of houseflies and their virulence properties were elucidated.
  • Master Thesis
    Secondary Metabolites From Marine Derived Actinobacteria and Their Bioactivities
    (01. Izmir Institute of Technology, 2024) Can, Özge; Bedir, Erdal
    Aktinobakteriler, antibakteriyel ve antikanser bileşikler dahil olmak üzere birçok biyoaktif ikincil metabolit üretebilmesi açısından dikkat çekmektedir. Bu tez kapsamında, İzmir (Türkiye) Ilıca Körfezi'nden Aktinobakteri olduğu öngörülen bakteriler izole edilerek antimikrobiyal potansiyelleri ortaya konmuştur. On iki izolatın fermantasyon sıvıları etil asetat ile ekstre edilerek, disk difüzyon testi ile seçilen patojenlere karşı (Staphylococcus aureus, Escherichia coli ve Candida albicans) taranmıştır. İzolatların çoğunluğu en az bir patojene karşı antimikrobiyal aktivite göstermiştir. Elde edilen izolatların morfolojik özelliklerine dayanarak Streptomyces üyeleri oldukları düşünülmüştür. Antimikrobiyal potansiyel ve ikincil metabolit profillerine dayanarak, 35M1 izolatı ileri çalışmalar için seçilmiştir. İlgili izolatın tüm genom dizilim (WGS) analizi sonucu türü Streptomyces sp. 35M1 olarak netleştirilmiş ve DDBJ/ENA/GenBank sistemine kaydedilmiştir (Erişim numarası: JBCLWP010000000). Preparatif ölçekli fermantasyonu takiben biyoaktivite rehberli izolasyon çalışmaları gerçekleştirilmiş, beş bileşik saflaştırılarak karakterize edilmiştir. Bu bileşikler; Actinomycin D (ActD), Actinomycin X2 (ActX2), Actinomycin XOβ (ActXOβ), Collismycin A (ColA) ve Collismycin C (ColC) olarak tanımlanmıştır. Sonrasında, ilgili moleküllerin antibiyofilm etkileri araştırılmış ve ActD ile ActX2'nin Metisiline dirençli Staphylococcus aureus, Listeria monocytogenes ve Staphylococcus epidermidis 'e karşı biyofilm inhibitör etkileri olduğu ortaya konmuştur. Son olarak, yeterli miktarda bulunan bileşikler ile (ActD, ActX2 ve ActXOβ) bir sinerjizm çalışması yapılmıştır. ActD ile Nalidiksik asit ve ActX2 ile Ampisilin, Nalidiksik asit ve Rifampisin kombinasyonları, gram-negatif E. coli 'ye karşı sinerjik etki göstermiş ve bu durum literatürde ilk kez rapor edilmiştir.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 2
    Bacterial Mirobiota and Chemical Properties of Turkish Tarhana
    (Slovak University of Agriculture, 2023) Al, Rabia; Yurt, Mediha Nur Zafer; Ersoy Ömeroğlu, Esra; Can, Özge; Temiz, Sevval Nur; Altunbas, Osman; Soyucok, Ali
    Tarhana is one of the traditional Turkish fermented food and it is served as a soup. In this study, bacterial microbiota and chemical properties (acidity, salt, and moisture content) of tarhana samples (n=96) were examined. The metagenomic analysis revealed that Firmicutes were the dominant phylum and Bacillaceae, Enterococcaceae, Paenibacillaceae, Enterobacteriaceae, and Clostridiaceae were the dominant bacterial families. In the samples, Bacillus, Enterococcus, and Paenibacillus were mostly identified at the genus level. Alpha diversity and evenness showed that sample 30 had the highest diversity collected from Izmir. Principal Coordinate Analysis was used to identify relationships of samples at different taxonomic levels and it was found that most of the samples were closely related at the phylum level. Chemical analysis indicated that the acidity of tarhana samples varied between 5.00% and 42.5%, moisture contents were 4.39- 18.66% and salt values were from 0.32% to 6.64%. The results of this study extensively demonstrated the chemical properties and the dominant bacterial communities present in tarhana samples collected from different parts of Turkiye.
  • Book
    Pandemi Döneminde Yükseköğretimde Engelli Öğrenci El Kitabı
    (Izmir Üniversiteler Platformu, 2020) Akmeşe, Pelin; Aslan, Soner; Tenikler, Gökhan; Varlıklı, Canan; Şahan, Gizem; Gedik, Zümrüt; Toker, Huriye; Can, Özge; Hıdır, Melis; Danacı, Miray Özözen; Görgün, Bora; Altun, Delal Gamze; Oral, Ezgi
    Covid-19 kısaltması ile bilinen ve tüm dünyayı etkisi altına alan virüs salgını nedeniyle ülkemizde 16 Mart 2020 tarihinde yüz yüze eğitime ara veren üniversiteler, Yükseköğretim Kurulu’nun (YÖK) aldığı kararla 2020-2021 eğitim-öğretim yılına uzaktan eğitim yöntemi ile başlamış olup salgının hala tehlikeli yayılışını sürdürmesi nedeniyle bu eğitim yöntemini kullanmaya devam etmektedir. John Hopkins Üniversitesi’nin verilerine göre dünya genelinde 52 milyon 824 bin kişinin yakalandığı, 1 milyon 294 binden fazla kişinin yaşamını yitirdiği küresel salgın (John Hopkins Üniversitesi, 13.11.2020), etkisini arttırarak ikinci kış döneminde sağlığımızı tehdit etmeye devam etmektedir. Üniversiteler eğitim-öğretim açısından diğer kademelere göre daha esnek ve çeşitlendirilmiş çalışma yöntemlerine sahip olsalar da üniversite öğrencileri yaşanan salgından etkilenmektedir. Üniversite öğrencilerinin arasında bulunan engelli öğrenci grubu da etkilenen kesimlerin başında gelmektedir. Türkiye’de nüfusun yüzde 12’sini oluşturan engelli bireyler, yükseköğretimde YÖK’ün 2019 yılı verilerine göre 47 bin 751 öğrenciden oluşmaktadır. Engelli öğrencilerin 38 bin 895’ini engel durumu bilinmeyenler, 2 bin 705’ini fiziksel engelli, 2 bin 316’sını kronik sağlık sorunu olanlar, 2 bin 31’ini görme ve bin 103’ünü işitme engelli öğrenciler oluşturmaktadır. Engel gruplarının temsilinde otizm spektrum bozukluğu, Asperger sendromu, öğrenme güçlüğü, dikkat eksikliği ve zihinsel yetersizliği olan öğrenciler az temsil edilmekteyse de ülkemizde 119 zihinsel engelli, 31 öğrenme güçlüğü olan, 58 dikkat eksikliği ve otizm tanısı alan, 21 de Asperger sendromu olan öğrenci yükseköğretimden yararlanmaktadır. Covid-19 salgını bizlere engelli öğrencilerin fiziksel erişim, eğitim içeriği gibi halihazırda var olan eşitsizliklerine eğitim içeriğine ulaşım ve özel gereksinimlerin karşılanması gibi ek önlemlerin alınması, uyarlamaların yapılması ve bu düzenlemelerin hızla gerçekleştirilmesi sorumluluğunu yükledi. İzmir Üniversiteler Platformu altında engellilik alanında üniversite öğrencilerinin yaşamını kolaylaştırmak adına çalışan alt çalışma grubumuz, Covid-19 salgını döneminde engelli öğrencilerin yaşadığı sorunlara değinmek ve uygulanan çözüm yollarını yaygınlaştırmak için bir el kitabı hazırlamıştır.
  • Article
    Citation - WoS: 35
    Citation - Scopus: 41
    Batch and Column Studies on Heavy Metal Removal Using a Local Zeolitic Tuff
    (Elsevier Ltd., 2010) Balköse, Devrim; Ülkü, Semra; Can, Özge
    Ion exchange is considered to be one of the most cost effective methods if low cost ion exchangers such as natural zeolites are used in waste water treatment. In this study, a zeolitic tuff rich in clinoptilolite from Gördes Manisa Turkey was examined to evaluate its ion exchange performance for the removal of copper, nickel and cobalt ions from metal (II) nitrate solutions at various concentrations by performing both batch and packed column experiments. A clinoptilolite tuff with purity around 60% was used in ion exchange experiments. Copper, nickel and cobalt exchange capacities of the tuff were determined as 8.3mg (0.26meq) Cu2+/g, 6.6mg (0.23meq) Ni2+/g and 4.5mg (0.15meq) Co2+/g, respectively. The equilibrium behavior of the system was best described by classical Langmuir model. The experimental breakthrough curves from the column experiments were fitted to solid diffusion control model. The study showed that efficient metal ion removal can be done by using the local clinoptilolite rich tuff. © 2010 Elsevier B.V.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 8
    Bioinspired Multi-Layer Biopolymer-Based Dental Implant Coating for Enhanced Osseointegration
    (Wiley, 2023) Üzülmez, Betül; Demirsoy, Zeynep; Can, Özge; Gülseren, Gulcihan
    The major drawbacks of metal-based implants are weak osseointegration and post-operational infections. These limitations restrict the long-term use of implants that may cause severe tissue damage and replacement of the implant. Recent strategies to enhance the osseointegration process require an elaborate fabrication process and suffer from post-operative complications. To address the current challenges taking inspiration from the extracellular matrix (ECM), the current study is designed to establish enhanced osseointegration with lowered risk of infection. Natural biopolymer pectin, peptide amphiphiles, and enzyme-mimicking fullerene moieties are governed to present an ECM-like environment around the implant surfaces. This multifunctional approach promotes osseointegration via inducing biomineralization and osteoblast differentiation. Application of the biopolymer-based composite to the metal surfaces significantly enhances cellular attachment, supports the mineral deposition, and upregulates osteoblast-specific gene expression. In addition to the osteoinductive properties of the constructed layers, the inherent antimicrobial properties of multilayer coating are also used to prevent infection possibility. The reported biopolymer-artificial enzyme composite demonstrates antimicrobial activity against Escherichia coli and Bacillus subtilis as a multifunctional surface coating.
  • Master Thesis
    Ion exchange in natural zeolite packed column
    (Izmir Institute of Technology, 2004) Can, Özge; Ülkü, Semra
    Turkish natural clinoptilolites were examined to evaluate their ion exchange performance for the removal of copper, nickel and cobalt ions by performing both batch and packed column experiments.Initial metal solutions were prepared using metal nitrate solutions at various concentrations.All of the experiments were carried out at 29oC.Before performing the ion exchange experiments zeolites were characterized and their clinoptilolite contents were determined quantitatively as 80 and 64 % for zeolites named as CP1 and CP2, respectively.The copper exchange capacities of CP1 and CP2 were determined from equilibrium studies as 10.01 mg (0.32 meq) Cu2+ / g CP1 and 8.33 mg (0.262 meq) Cu2+ / g CP2. Ion exchange capacity of CP2 zeolite was determined as 6.64 mg (0.226 meq) Ni2+ / g and 4.55 mg (0.154 meq) Co2+ / g.The equilibrium behaviour of the system was best described by Langmuir model.Experiments were designed to investigate the optimum parameters and significance of the interactions between these parameters.In column studies, the parameters such as packing height, inlet metal concentration and flow rate were investigated.The concentration of the metals in the sample solutions which were taken from the exit of the ion exchange column at specific time intervals were analyzed by using Optical Emission Spectrometry (ICP-OES).Afterwards, by making use of the data obtained from ICP-OES, breakthrough curves were constructed.By the help of these curves, breakthrough capacity and ion exchange capacity of natural zeolites were calculated.The ion exchange capacity of CP2 zeolite was calculated as 8.04 mg Cu2+/g CP2, which was consistent with the capacity calculated from batch experiments, 8.33 mg Cu2+/g CP2.Also, breakthrough points were determined. Furthermore, solid phase was also analysed for determining its crystal structure and chemical composition using Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray (EDX) devices (Philips XL 30S FEG).In addition to these, natural zeolite particles which have been ion exchanged throughout this process were regenerated using 0.2M and 1.7M of NaCl solutions.According to regeneration studies, it was determined that 94 and 95% of copper were recovered within the first 100 minutes for both experiments.After the experiments were performed, model equations were applied to the system in order to be able to investigate the dynamic behavior of the system.As a result of this simulation, breakthrough was well predicted.