Tıhmınlıoğlu, Funda
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Tıhmınlıoğlu, F.
Tihminlioglu, F
Tihminlioglu, F.
Tihminlioglu, Funda
Tıhmınlıoğlu, F
Tihminlioglu, F
Tihminlioglu, F.
Tihminlioglu, Funda
Tıhmınlıoğlu, F
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Email Address
fundatihminlioglu@iyte.edu.tr
Main Affiliation
03.02. Department of Chemical Engineering
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Current Staff
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Sustainable Development Goals
1NO POVERTY
0
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2ZERO HUNGER
5
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3GOOD HEALTH AND WELL-BEING
10
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4QUALITY EDUCATION
2
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5GENDER EQUALITY
0
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6CLEAN WATER AND SANITATION
12
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7AFFORDABLE AND CLEAN ENERGY
16
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8DECENT WORK AND ECONOMIC GROWTH
7
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9INDUSTRY, INNOVATION AND INFRASTRUCTURE
29
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10REDUCED INEQUALITIES
0
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11SUSTAINABLE CITIES AND COMMUNITIES
0
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12RESPONSIBLE CONSUMPTION AND PRODUCTION
15
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13CLIMATE ACTION
16
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14LIFE BELOW WATER
3
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15LIFE ON LAND
0
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16PEACE, JUSTICE AND STRONG INSTITUTIONS
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17PARTNERSHIPS FOR THE GOALS
0
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Documents
67
Citations
2947
h-index
29
Documents
73
Citations
2601
Scholarly Output
93
Articles
54
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126618/46884
Supervised MSc Theses
15
Supervised PhD Theses
5
WoS Citation Count
2500
Scopus Citation Count
2845
Patents
1
Projects
20
WoS Citations per Publication
26.88
Scopus Citations per Publication
30.59
Open Access Source
74
Supervised Theses
20
| Journal | Count |
|---|---|
| Journal of Applied Polymer Science | 7 |
| Helicobacter | 6 |
| International Journal of Biological Macromolecules | 4 |
| Journal of Polymer Science, Part B: Polymer Physics | 4 |
| Materials Science and Engineering C | 3 |
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Conference Object Citation - WoS: 1Citation - Scopus: 1Modification of Surface Morphology of Uhmwpe for Biomedical Implants(Materials Research Society, 2007) Öztarhan, Ahmet; Sokullu Urkaç, Emel; Kaya, Nusret; Yenigül, Mesut; Tıhmınlıoğlu, Funda; Ezdeşir, Ayhan; Zimmerman, Robert; Budak, Satılmış; Muntele, C.; Chhay, Bopha; Ila, Daryush; Oks, Efim; Nikolaev, Alexey; Tek, Zekai; Eltem, RenginUltra High Molecular Weight Polyethylene (UHMWPE) samples were implanted with metal and metal-gas hybrid ions (Ag, Ag+N, C+H, C+H+Ar, Ti+O) by using improved MEVVA Ion implantation technique [1,2]. An extraction voltage of 30 kV and influence of 1017 ions/cm2 were attempted in this experiment, to change their surface morphologies in order to understand the effect of ion implantation on the surface properties of UHMWPEs. Characterizations of the implanted samples with RBS , ATR - FTIR, spectra were compared with the un-implanted ones . Implanted and unimplanted samples were also thermally characterized by TGA and DSC. It was generally observed that C-H bond concentration seemed to be decreasing with ion implantation and the results indicated that the chain structure of UHMWPE were changed and crosslink density and polymer crystallinity were increased compared to unimplanted ones resulting in increased hardness. It was also observed that nano size cracks (approx.10nm) were significantly disappeared after Ag implantation, which also has an improved antibacterial effect. Contact angle measurements showed that wettability of samples increased with ion implantation. Results showed that metal and metal+gas hybrid ion implantation could be an effective way to improve the surface properties of UHMWPE to be used in hip and knee prosthesis.Article Citation - WoS: 17Citation - Scopus: 16Development of Cissus Quadrangularis-Loaded Poss-Reinforced Chitosan-Based Bilayer Sponges for Wound Healing Applications: Drug Release and in Vitro Bioactivity(American Chemical Society, 2023) Değer Aker, Sibel; Tamburacı, Sedef; Tıhmınlıoğlu, FundaNowadays, antibiotic-loaded biomaterials have been widelyusedin wound healing applications. However, the use of natural extractshas come into prominence as an alternative to these antimicrobialagents in the recent period. Among natural sources, Cissus quadrangularis (CQ) herbal extract is usedfor treatment of bone and skin diseases in ayurvedic medicine dueto its antibacterial and anti-inflammatory effects. In this study,chitosan-based bilayer wound dressings were fabricated with electrospinningand freeze-drying techniques. CQ extract-loaded chitosan nanofiberswere coated on chitosan/POSS nanocomposite sponges using an electrospinningmethod. The bilayer sponge is designed to treat exudate wounds whilemimicking the layered structure of skin tissue. Bilayer wound dressingswere investigated with regard to the morphology and physical and mechanicalproperties. In addition, CQ release from bilayer wound dressings and in vitro bioactivity studies were performed to determinethe effect of POSS nanoparticles and CQ extract loading on NIH/3T3and HS2 cells. The morphology of nanofibers was investigated withSEM analysis. Physical characteristics of bilayer wound dressingswere determined with FT-IR analysis, swelling study, open porositydetermination, and mechanical test. The antimicrobial activity ofCQ extract released from bilayer sponges was investigated with a discdiffusion method. Bilayer wound dressings' in vitro bioactivity was examined using cytotoxicity determination, woundhealing assay, proliferation, and the secretion of biomarkers forskin tissue regeneration. The nanofiber layer diameter was obtainedin the range of 77.9-97.4 nm. The water vapor permeabilityof the bilayer dressing was obtained as 4021 to 4609 g/m(2)day, as it is in the ideal range for wound repair. The release ofthe CQ extract over 4 days reached 78-80% cumulative release.The release media were found to be antibacterial against Gram-negativeand Gram-positive bacteria. In vitro studies showedthat both CQ extract and POSS incorporation induced cell proliferationas well as wound healing activity and collagen deposition. As a result,CQ-loaded bilayer CHI-POSS nanocomposites were found as a potentialcandidate for wound healing applications.Doctoral Thesis Natural and Synthetic Silica Incorporated Chitosan Composite Scaffolds for Bone Tissue Engineering Applications(İzmir Institute of Technology, 2016) Tamburacı, Sedef; Tıhmınlıoğlu, Funda; Tıhmınlıoğlu, Funda; Havıtçıoğlu, HasanRecently bone tissue engineering studies have focused on the development of 3D scaffolds that can organize the tissue regeneration in natural way with appropriate porosity and reinforced the structure. Natural polymer-based composites have been focused with more attention than synthetic polymer composites for bone tissue engineering applications because of their biocompatibility and biodegradability. In this work, the goal was to combine the useful biomaterial properties of both chitosan and silica to design biocomposite organic/inorganic biomaterials for bone tissue engineering applications. The composite scaffolds were fabricated by freeze drying method bu using two different silicas; natural silica; Diatomite and synthetic silica, octa (tetramethylammonium) polyhedral oligomeric silsesquioxanes (OctaTMA-POSS). The effects of silica type and loading on the mechanical, morphological, chemical, surface properties, wettability and biocompatibility of composite scaffolds were investigated and characterized by using SEM, AFM, contact angle analysis, swelling study, protein adsorption assay, biodegradation and biomineralization tests. WST-1 cytotoxicity, cell proliferation with rezasurin and alkaline phosphatase activity assays were performed to determine biological activity of the composite scaffolds. In vitro biomineralization on scaffolds was determined by Von Kossa and Alizarin red staining. POSS and diatomite incorporation increased the surface roughness. Chitosansilica composites exhibited 82-90% porosity. Wet chitosan-silica composite scaffolds exhibited higher compression moduli compared to pure chitosan scaffold in 67.3- 81.4kPa and 78.1 to 107.6kPa range respectively. Average pore size range of chitosandiatomite and chitosan-POSS composite scaffolds was obtained as 15-180μm and 220- 300μm, respectively. Results indicated that chitosan-silica composites did not show any cytotoxic effect on 3T3, MG-63 and Saos-2 cell lines. Chitosan-silica composites were found to be favorable for osteoblast proliferation. Diatomite and POSS incorporation showed promising effects with enhancing ALP activity on hFob cells. Therefore, these composite scaffolds could be used for bone tissue engineering applications.Article Citation - WoS: 69Citation - Scopus: 77Novel Zein-Based Multilayer Wound Dressing Membranes With Controlled Release of Gentamicin(John Wiley and Sons Inc., 2019) Kimna, Ceren; Tamburacı, Sedef; Tıhmınlıoğlu, FundaRecently, functional multilayer scaffolds with controlled drug release ability come into prominence for wound healing applications to mimic the layered structure of skin tissue and prevent the possible infections at the defect site. In this study, controlled antibiotic releasing zein bilayer membranes were fabricated for treatment of acute skin infections. Gentamicin loaded fibers were prepared by electrospinning on the membrane surface. Membranes were characterized with scanning electron microscope, atomic force microscopy, Fourier transform infrared spectroscopy, contact angle, mechanical analysis, swelling, degradation, and water vapor permeability studies. In vitro cytotoxicity, cell attachment, and proliferation were investigated. Cell attachment on fiber layer was observed with fluorescence imaging. Fabricated fibers showed structural similarity to the skin tissue layers with a fiber diameter range of 350-425 nm and film thickness in the range of 311-361 mu m. Mechanical properties were found compatible with the skin tissue. In addition, membranes showed antimicrobial activity against Staphylococcus aureus and Escherichia coli. The sustained release was achieved with a cumulative release of 94%. Membranes did not show any cytotoxic effect. NIH/3T3 and HS2 cell lines were proliferated on each layer mimicking the multilayer skin tissue. Hence, zein-based bilayer membrane showed promising properties to be used as a potential antimicrobial wound dressing for skin tissue regeneration. (c) 2018 Wiley Periodicals, Inc.Master Thesis Manufacturing of Starch-Based Bioplastic From Waste Potato Starch by Extrusion and Energy Analysis of the Production(2023) Tıhmınlıoğlu, Funda; Gökyıldız, Yasemin; Alsoy Altınkaya, Sacide; Altınkaya, Sacide; Tıhmınlıoğlu, FundaPlastic materials are an essential part of our daily lives and annual plastic production is higher than 380 million tons with a 4% annual increasing rate. Since the 1950s, 8.3 billion tons of plastic have been produced, 9% of these plastics have been recycled, 12% have been incinerated and the rest 79% have been dumped to landfills. Therefore, the development of biodegradable polymers obtained from renewable raw materials has become a priority to reduce the environmental impact and dependency on fossil resources. Thermoplastic starch (TPS) is a starch-based bioplastic obtained by the disruption of the starch granules with thermal and mechanical forces in the presence of plasticizer. In this thesis, production of TPS from residual potato starch by extrusion was investigated. The extrusion trials were conducted in a single-screw extruder. Glycerol was selected as plasticizer and added to starch with 20, 30 and 40 wt.%. Extrusion temperature profiles were 50-90oC, 60-90oC and 70-90oC. The pretreatment conditions for the residual starch were drying to 10 wt.% moisture content and sieving with 131μm mesh size. Specific mechanical energy values ranged between 7.89 kWhkg-1 and 43.27 kWhkg-1. The optimum product formation was selected according to processability with lower energy consumption and mechanical properties as TPS303 which has 30 wt.% glycerol content and processed between 70-90oC. Specific mechanical energy consumption for TPS303 was found to be 23.78 kWhkg-1. The mechanical properties of TPS303 were 4.48 MPa tensile strength, 59.74 MPa Young's modulus and 57.33% elongation at break. Consequently, residual potato starch was found to be a promising raw material for thermoplastic starch production with proper pretreatment.Article Citation - WoS: 23Citation - Scopus: 27Novel Poss Reinforced Chitosan Composite Membranes for Guided Bone Tissue Regeneration(Springer Verlag, 2018) Tamburacı, Sedef; Tıhmınlıoğlu, FundaIn this study, novel composites membranes composed of chitosan matrix and polyhedral oligomeric silsesquioxanes (POSS) were fabricated by solvent casting method. The effect of POSS loading on the mechanical, morphological, chemical, thermal and surface properties, and cytocompatibility of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively. Swelling studies were also performed by water absorption capacity determination. Results showed that incorporation of Octa-TMA POSS® nanofiller to the chitosan matrix increased the surface roughness, protein adsorption and swelling capacity of membranes. The addition of POSS enhanced significantly the ultimate tensile strength and strain at break of the composite membranes up to 3 wt% POSS loaded samples. An increase of about 76% in tensile strength and of strain at break 1.28% was achieved for 3 wt% POSS loaded nanocomposite membranes compared with chitosan membranes. The presence of POSS filler into polymer matrix increased the plasma protein adsorption on the surface. Maximum protein capacity and swelling was obtained for 10 wt% loaded samples. High cell viability results were obtained with indirect extraction of chitosan/POSS composites. Besides, cell proliferation and ALP activity results showed that POSS incorporation significantly increased the ALP activity of Saos-2 cells cultured on chitosan membranes. This novel composite membranes with tunable properties could be considered as a potential candidate for guided bone regeneration applicationsArticle Citation - WoS: 96Citation - Scopus: 113Hypericum Perforatum Incorporated Chitosan Films as Potential Bioactive Wound Dressing Material(Elsevier Ltd., 2017) Güneş, Seda; Tıhmınlıoğlu, FundaRecent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John's Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan films were successfully prepared by solvent casting method in different oil concentrations (0.25–1.5%v/v). Water vapor permeability (WVP), mechanical test, swelling behavior and surface hydrophobicity were performed in order to characterize the prepared films. Antimicrobial test was performed by disc diffusion method and the growth inhibition effects of the films including different amount of H. perforatum oil were investigated on Escherichia coli and Staphylococcus aureus. WVP increased with oil incorporation and the highest value was obtained for 0.25% oil concentration.The highest strain value was obtained in 0.25% oil content films although tensile stress decreased with increasing oil content. H. perforatum oil incorporated films had antimicrobial effect on both microorganisms. Chitosan based films had no cytotoxic effects on NIH3T3fibroblast cells and provided a good surface for cell attachment and proliferation. The results showed that the H. perforatum incorporated chitosan films seems to be a potential and novel biomaterial for wound healing applications.Article Citation - WoS: 30Citation - Scopus: 31Water and Water Vapor Sorption Studies in Polypropylene-Zeolite Composites(Wiley, 2003) Pehlivan, Hilal; Özmıhçı, Filiz; Tıhmınlıoğlu, Funda; Balköse, Devrim; Ülkü, SemraWater and water vapor sorption to porous polypropylene-zeolite composites prepared by hot pressing have been studied as a function of zeolite loading. This work presents the first report on the effect of the zeolite as a filler on the water-sorption properties of PP composites. Water swelling experiments were conducted at 25°C using pure PP and PP-zeolite films samples having different zeolite loadings (6-40 wt %). Because PP is a hydrophobic polymer, it does not sorp any water, but the composites having 10, 20, 30, and 40% zeolites have sorbed 0.63, 1.00, 1.72 and 3.74% water, respectively. The zeolite itself at the same conditions sorbed 24.5% water. As the filler loading in the composites increased, equilibrium uptake values increased also. On the other hand, water vapor sorption and kinetics has been studied using a Cahn 2000 gravimetric sorption system. Within in the range of 0.35-0.95% water vapor was adsorbed by the composites containing 10-40 wt % zeolites. Experimental effective water vapor diffusivities of the composite films was about one order of magnitude higher (10-fold) than the experimental water diffusion coefficient in composites. The transport of water in composites was slower than that in the liquid water due to the longer diffusion pathway and adsorption on the surface of the composites. Although the liquid water may fill all the voids in the composite, water vapor is adsorbed on the surface of the zeolite only.Article Citation - WoS: 347Citation - Scopus: 397Physical, Antibacterial and Antioxidant Properties of Chitosan Films Incorporated With Thyme Oil for Potential Wound Healing Applications(Springer Verlag, 2010) Altıok, Duygu; Altıok, Evren; Tıhmınlıoğlu, FundaChitosan films incorporated with thyme oil for potential applications of wound dressing were successfully prepared by solvent casting method. The water vapor permeability, oxygen transmission rate, and mechanical properties of the films were determined. Surface and cross-section morphologies and the film thicknesses were determined by Scanning Electron Microscopy (SEM). Fourier transform infrared (FT-IR) spectroscopy was conducted to determine functional group interactions between the chitosan and thyme oil. Thermal behaviors of the films were analyzed by Thermal Gravimetry (TGA) and Differential Scanning Calorimetry (DSC). In addition, the antimicrobial and the antioxidant activities of the films were investigated. The antimicrobial test was carried by agar diffusion method and the growth inhibition effects of the films including different amount of thyme oil were tested on the gram negative microorganisms of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and a gram positive microorganism of Staphylococcus aureus. The minimum thyme oil concentration in chitosan films showing the antimicrobial activity on all microorganisms used in the study was found as 1.2 % (v/v). In addition, this concentration showed the highest antioxidant activity due to mainly the carvacrol in thyme oil. Water vapor permeability and oxygen transmission rate of the films slightly increased, however, mechanical properties decreased with thyme oil incorporation. The results revealed that the thyme oil has a good potential to be incorporated into chitosan to make antibacterial and permeable films for wound healing applications. © 2010 Springer Science+Business Media, LLC.Article Citation - WoS: 18Citation - Scopus: 22Application of Inverse Gas Chromatography To the Measurement of Diffusion and Phase Equilibria in Polyacrylate-Solvent Systems(Elsevier Ltd., 1999) Tıhmınlıoğlu, Funda; Danner, Ronald P.The inverse gas chromatography technique (IGC) was used to determine the partition and diffusion coefficients of ethyl acetate and 2-ethylhexyl acrylate in polyacrylate for both infinite dilution and finite concentrations of solvent. Experiments were performed over a temperature range of 60 to 100°C, more than 100°C above the glass transition temperature of the polymer. The capillary column IGC model previously developed for determining partition and diffusion coefficients of infinitely dilute solvent has been modified to account for the concentration of the solvent in the polymer phase. Thermodynamic data obtained from retention theory and the modified capillary column IGC model are compared