Batıgün, Ayşegül
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Batigun, Aysegul
Batıgün, A.
Batigun, A.
Batigün, Ayşe Gül
Batıgün, A.
Batigun, A.
Batigün, Ayşe Gül
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03.02. Department of Chemical Engineering
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9
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WoS Citation Count
222
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246
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24.67
Scopus Citations per Publication
27.33
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9
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4
| Journal | Count |
|---|---|
| 14th National Biomedical Engineering Meeting, BIYOMUT 2009 | 1 |
| European Journal of Pharmaceutics and Biopharmaceutics | 1 |
| International Journal of Biological Macromolecules | 1 |
| International Journal of Pharmaceutics | 1 |
| Journal of Thermal Analysis and Calorimetry | 1 |
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9 results
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Now showing 1 - 9 of 9
Master Thesis Use of Fibroin/Hyaluronic Acid Matrices as a Drug Reservoir in Iontophoretic Transdermal Delivery(Izmir Institute of Technology, 2004) Kuduğ, Emre; Batıgün, AyşegülTransdermal drug delivery is gaining importance due to the extensive research in genetics and resulting increase of protein and peptide based drugs in the market. In order to develop materials to be used in iontophoretic transdermal drug delivery systems, various forms of silk fibroin (SF) and blending agents as hyaluronic acid (HA) have been tested for their feasibility as a potential drug reservoir. For this purpose different forms of silk such as raw silk, degummed silk fibroin, insolubilized freezedried fibroin, membranes of fibroin in pure and blended with HA were investigated for their adsorption capacities of timolol maleate, which is used as the model drug. It was found that silk fibroin and derivatives have considerable adsorption capacities for timolol maleate with 0.35 mmol per gram, comparable with commercial membranes. The insolubilization of the membranes was required for drug loading and delivery in aqueous media. Membrane insolubility was achieved by post treatment, manipulation of drying conditions, and blending with different agents. Configurational changes of fibroin protein and interactions between silk fibroin and hyaluronic acid were investigated by Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction analyses. Insoluble fibroin glutaraldehyde membranes were produced. The obtained insoluble membranes were investigated for drug delivery performance in a custom-made diffusion cell under passive diffusion and iontophoretic conditions. It was demonstrated that the silk fibroin glutaraldehyde films could be successfully used for controlled drug delivery. It was found that current densities of 1.5 and 3 mA/cm2 were suitable to accomplish controlled delivery of the drug in a pulsatile manner. The results of this study are expected to be useful in controlled transdermal delivery of positively charged drug molecules.Master Thesis Modelling and Control of Bioprocesses by Using Artificial Neural Networks and Hybridmodel(Izmir Institute of Technology, 2006) Genç, Ömer Sinan; Batıgün, Ayşegül; Batıgün, AyşegülThe aim of this study is modeling and control of bioprocesses by using neural networks and hybrid model techniques. To investigate the modeling techniques, ethanol fermentation with Saccharomyces Cerevisiae and recombinant Zymomonas mobilis and finally gluconic acid fermentation with Pseudomonas ovalis processes are chosen.Model equations of these applications are obtained from literature. Numeric solutions are done in Matlab by using ODE solver. For neural network modeling a part of the numerical data is used for training of the network.In hybrid modeling technique, model equations which are obtained from literature are first linearized then to constitute the hybrid model linearized solution results are subtracted from numerical results and obtained values are taken as nonlinear part of the process. This nonlinear part is then solved by neural networks and the results of the neural networks are summed with the linearized solution results. This summation results constitute the hybrid model of the process. Hybrid and neural network models are compared. In some of the applications hybrid model gives slightly better results than the neural network model. But in all of the applications, required training time is much more less for hybrid model techniques. Also, it is observed that hybrid model obeys the physical constraints but neural network model solutions sometimes give meaningless outputs.In control application, a method is demonstrated for optimization of a bioprocess by using hybrid model with neural network structure. To demonstrate the optimization technique, a well known fermentation process is chosen from the literature.Article Citation - WoS: 16Citation - Scopus: 21Ph- and Electro-Responsive Characteristics of Silk Fibroin-Hyaluronic Acid Polyelectrolyte Complex Membranes(Elsevier Ltd., 2009) Malay, Özge; Batıgün, Ayşegül; Bayraktar, OğuzpH-responsiveness of recently developed silk fibroin (SF) and hyaluronic acid (HA) polyelectrolyte complex (PEC) membranes and their potential use in electro-responsive drug release systems were investigated. PEC membranes were prepared within a narrow pH window (3.0-3.5) for a SF-HA weight ratio of 20 and they were characterized by Atomic Force Microscopy in addition to characterization studies previously reported by our group. Swelling kinetics of the membranes was studied for a pH window of 2.5-7.4 and cyclic swelling test was performed to determine the pH-responsiveness of the membranes. It was shown that membranes swelled more in alkaline conditions and responded to variations in pH of the medium. Electric-stimuli assisted drug permeation and release studies were performed with a custom-made diffusion cell under both passive condition and electric field applied in pulsatile fashion. The instantaneous flux raised as the current was applied and then declined when the current application was terminated, and this process was repeated on subsequent applications. SF-HA complex membranes were found promising for the electric-stimuli-sensitive release of a high molecular weight and charged model drug for a membrane-permeation controlled formulation.Article Citation - WoS: 32Citation - Scopus: 33Characterization of Silk Fibroin/Hyaluronic Acid Polyelectrolyte Complex (pec) Films(Springer Verlag, 2008) Malay, Özge; Yalçın, Dilek; Batıgün, Ayşegül; Bayraktar, OğuzThis study aimed the characterization of the films casted from the aqueous mixtures of the pH induced complexes between silk fibroin (SF) and hyaluronic acid (HA). The insoluble and transparent films were subjected to scanning electron microscopy (SEM) analyses to show the morphological changes. Thermal analysis of complex films was determined by a differential scanning calorimeter (DSC). The changes in the crystalline state were monitored by X-ray diffractometer (XRD) and Fourier transform infrared spectroscopy (FTIR). It was shown that the complexation between HA and SF was dominantly induced by pH. It was shown that the complex films comprised mixtures of crystalline and non-crystalline regions.Conference Object Hidrofobik İlaç Taşıyıcısı Olarak Akrilik Yıldız Blok Kopolimerler(Institute of Electrical and Electronics Engineers Inc., 2009) Genç, Gözde; Batıgün, Ayşegül; Bayraktar, Oğuz; Altıntaş, Özcan; Tunca, Ümit; Hizal, GürkanAmphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.Article Citation - WoS: 68Citation - Scopus: 70Complex Coacervation of Silk Fibroin and Hyaluronic Acid(Elsevier Ltd., 2007) Malay, Özge; Bayraktar, Oğuz; Batıgün, AyşegülThis study aimed to investigate the pH-induced complexation of silk fibroin (SF) and hyaluronic acid (HA). SF-HA complex coacervation was investigated by monitoring turbidity of the SF-HA system under slow acidification. Gravimetric analysis was performed to determine the yield of complex coacervation and viscosity of the system was measured to study the formation of the complexes at different pH values. The influences of total biopolymer concentration and biopolymer weight ratio on complex coacervation were examined during the analyses. Formation of the complexes was evidenced by the minimum viscosity and the maximum turbidity observed in the system. SF-HA complexes were formed within the pH-window of 2.5-3.5 regardless of the total biopolymer concentration or biopolymer ratio. Complex coacervation of SF-HA showed a reversible behavior and coacervation could be handled even in excess amounts of the biopolymers, which pointed out a non-stoichiometric complexation.Doctoral Thesis Synthesis and Characterization of Star Block Copolymer for Controlled Drug Delivery(Izmir Institute of Technology, 2010) Atikler Genç, Gözde; Batıgün, AyşegülAmphiphilic multiarm block copolymers of hydrophobic poly(methyl methacrylate) core and hydrophilic poly(acrylic acid) corona has been synthesized, characterized and proposed for an anticancer drug that is 5 Florouracil (5FU). 3 arm, 4 arm and 6 arm PMMA-b-PtBA (poly(methyl methacrylate-block-poly(tertiary butyl acrylate)) copolymers with molecular weights from 18 kDa to 80 kDa were synthesized by Atomic Transfer Radical Polymerization and reacted into PMMA-b-PAA (poly(methyl methacrylate-block-poly(acrylic acid)) by hydrolysis of tBA chains. Optimum molecular weight and hydrophobic core ratio was determined by evaluation of critical micelle concentrations and maximum loading capacities with pyrene. Loading method was selected among simple equilibrium, solvent deposition, salting out and dialysis methods. Dialysis method yielded the highest loading contents of model drug indomethacin. Optimum loading conditions in terms of temperature, duration, pH and polymer concentration were determined with anticancer drug 5FU. 4 arm PMMA-b-PAA with molecular weight 18000 Da and hydrophobic core ratio 0.27 was proposed for controlled delivery of 5FU. Optimum loading conditions were determined as 15C in acidic aqueous medium with pH 1.0-1.5 and loading interval as 4 hours. Minimum polymer concentration was estimated to be 2000 mg/L for an optimum loading. Drug loaded particles were characterized by FTIR, TGA, DTG and DSC. 5FU loaded PMMA-b-PAA samples with drug contents about 14-20 % were investigated by a continuous operation where a diffusion cell was employed to monitor release profiles. Controlled release of 5FU with zero order release kinetics for 18 days was provided by 4 arm PMMA-b-PAA. Biodegradation of loaded particles were monitored through particle size analysis by Dynamic Light Scattering and Atomic Force Microscopy.Article Citation - WoS: 106Citation - Scopus: 122Silk Fibroin as a Novel Coating Material for Controlled Release of Theophylline(Elsevier Ltd., 2005) Bayraktar, Oğuz; Malay, Özge; Özgarip, Yarkın; Batıgün, AyşegülThe aim of this study was to explore potential use of the silk fibroin (SF) as an aqueous coating material for theophylline tablets. We have examined the film forming and coating properties of heat-treated fibroin, SF solution having different amounts of polyethylene glycol (PEG) and 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDC) cross-linked SF. Heat-treated SF material possessed a brittle structure, which resulted in poor film forming and coating properties. The optimum PEG amount in SF solution was determined as 17% (by weight) for an acceptable film forming and zero order release profile. EDC cross-linked SF has shown a very good film forming and coating property with a potential for sustaining the drug release from coated theophylline tablets. Dissolution data for coated theophylline tablets were analyzed using Ritger and Peppas equation to describe the mechanism of drug release. Drug release from the EDC coated tablets followed zero-order kinetics. Release rate constants were found to be 0.26, 0.19, 0.16% min-1 for single-coated, double coated, and triple coated tablets, respectively. These results clearly demonstrated that silk fibroin has high utility as a novel aqueous coating material for controlled release products.Master Thesis Formation and Characterization of Silk Fibroin/Hyaluronic Acid Complexes and Their Use in Iontophoretic Drug Delivery(Izmir Institute of Technology, 2005) Malay, Özge; Batıgün, AyşegülThis study aimed the investigation of the pH-induced complexation of silk fibroin (SF) and hyaluronic acid (HA), and the potential use of the films casted from the aqueous mixtures of the SF-HA complexes in iontophoretic drug delivery applications.In the present study, SF-HA complex coacervation was investigated by turbidimetric, conductometric, gravimetric and viscosimetric analysis with respect to changes in total biopolymer concentration and biopolymer weight ratio. SF-HA complexes were formed within the pH-window of 2.5-3.5 regardless of the totalbiopolymer concentration, biopolymer ratio or mixing order.SF-HA aqueous complex mixtures, prepared under previously determined conditions, were casted and dried under controlled conditions. The resultant insoluble and transparent films were subjected to instrumental analysis such as DSC, XRD, FT-IR,SEM and AFM. Swelling kinetics of the films was studied for pH window of 2.5-7.4 and cyclic swelling test was performed to determine the pH-responsiveness of the films. It was shown that films swelled more in alkaline conditions and responded to the changes in pH of the medium. The permeability of the films were tested with modified-diffusion-vessels method at pH 2.5 and 7.4 and it was demonstrated that the complex films had higher permeability in alkaline condition. Eventually, iontophoretically assisted drug permeation and release studies were performed with a custom-made diffusion cell under both passive condition and electric field applied in pulsatile fashion.In conclusion, SF-HA complex films were found promising for the iontophoretic delivery of high molecular weight and charged drugs for a membrane-permeation controlled formulation. In this study, timolol maleate (TM) was used as the model drug.