Türker, Esra

Profile URL
https://hdl.handle.net/11147/16305
Name Variants
Turker, Esra
Job Title
Email Address
Main Affiliation
01.01. Units Affiliated to the Rectorate
Status
External
Website
ORCID ID
0000-0002-9328-5513
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
haEaENoAAAAJ
WoS Researcher ID

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
Research Products
GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
0
Research Products
QUALITY EDUCATION4
QUALITY EDUCATION
0
Research Products
GENDER EQUALITY5
GENDER EQUALITY
0
Research Products
CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
1
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
1
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
3
Research Products
REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
Research Products
SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
CLIMATE ACTION13
CLIMATE ACTION
0
Research Products
LIFE BELOW WATER14
LIFE BELOW WATER
0
Research Products
LIFE ON LAND15
LIFE ON LAND
0
Research Products
PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
Research Products
This researcher does not have a Scopus ID.
This researcher does not have a WoS ID.

Publication Collaboration

Affiliation Name Count
Universitätsklinikum Würzburg 7
Friedrich-Alexander-Universität Erlangen-Nürnberg 5
Universitätsklinikum Erlangen 5
Bavarian Polymer Institute 5
Izmir Institute of Technology 4
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Data obtained from OpenAlex
Scholarly Output

6

Articles

3

Views / Downloads

7068/3767

Supervised MSc Theses

1

Supervised PhD Theses

0

WoS Citation Count

157

Scopus Citation Count

169

Patents

0

Projects

0

WoS Citations per Publication

26.17

Scopus Citations per Publication

28.17

Open Access Source

5

Supervised Theses

1

JournalCount
Biomaterials Science2
20th National Biomedical Engineering Meeting1
ACS Biomaterials Science and Engineering1
International Journal of Biological Macromolecules1
Current Page: 1 / 1

Scopus Quartile Distribution

Competency Cloud

GCRIS Competency Cloud
Author of Publication: search.filters.isAuthorOfPublication.f6af5d89-6ad0-494d-a6e0-d0fe4a92d87d

Scholarly Output Search Results

Now showing 1 - 6 of 6
  • Correction
    Citation - WoS: 2
    Citation - Scopus: 2
    Correction: Scaffold-Free Three-Dimensional Cell Culturing Using Magnetic Levitation
    (Royal Society of Chemistry, 2018) Türker, Esra; Arslan Yıldız, Ahu; Arslan Yıldız, Ahu; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    The authors regret the inclusion of an incorrect figure caption for Fig. 2. The corrected figure caption for Fig. 2 is shown below. Fig. 2 Evaluation of levitation height (z) and density profiles through magnetic levitation. (A) Gd(III) chelates were named as Gx (Gadovist/Gadobutrol), Dx (Dotarem/Gadoteric acid) and Ox (Omniscan/Gadodiamide). (B) Standard curve for PE bead density against levitation height; linear curve fitting gives the standard function for the corresponding curve. (C–E) Levitation height profiles of single NIH 3T3 cells under 30/50/100/200 mM Gd concentrations. Single cell density profiles calculated through standard function of linear fitting.
  • Article
    Citation - WoS: 34
    Citation - Scopus: 36
    Biomimetic Hybrid Scaffold Consisting of Co-Electrospun Collagen and Pllcl for 3d Cell Culture
    (Elsevier Ltd., 2019) Türker, Esra; Yıldız, Ümit Hakan; Yıldız, Ümit Hakan; Arslan Yıldız, Ahu; Arslan Yıldız, Ahu; Türker, Esra; 04.01. Department of Chemistry; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 04. Faculty of Science
    Electrospun collagen is commonly used as a scaffold in tissue engineering applications since it mimics the content and morphology of native extracellular matrix (ECM) well. This report describes "toxic solvent free" fabrication of electrospun hybrid scaffold consisting of Collagen (Col) and Poly(L-lactide-co-epsilon-caprolactone) (PLLCL) for three-dimensional (3D) cell culture. Biomimetic hybrid scaffold was fabricated via co-spinning approach where simultaneous electrospinning of PLLCL and Collagen was mediated by polymer sacrificing agent Polyvinylpyrrolidone (PVP). Acidified aqueous solution of PVP was used to solubilize collagen without using toxic solvents for electrospinning, and then PVP was readily removed by rinsing in water. Mechanical characterizations, protein adsorption, as well as biodegradation analysis have been conducted to investigate feasibility of biomimetic hybrid scaffold for 3D cell culture applications. Electrospun biomimetic hybrid scaffold, which has 3D-network structure with 300-450 nm fiber diameters, was found to be maximizing cell adhesion through assisting NIH 3T3 mouse fibroblast cells. 3D cell culture studies confirmed that presence of collagen in biomimetic hybrid scaffold have created a major impact on cell proliferation compared to conventional 2D systems on long-term, also cell viability increased with the increasing amount of collagen. (c) 2019 Elsevier B.V. All rights reserved.
  • Article
    Citation - WoS: 46
    Citation - Scopus: 57
    Recent Advances in Magnetic Levitation: a Biological Approach From Diagnostics To Tissue Engineering
    (American Chemical Society, 2018) Türker, Esra; Arslan Yıldız, Ahu; Arslan Yıldız, Ahu; Türker, Esra; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    The magnetic levitation technique has been utilized to orientate and manipulate objects both in two dimensions (2D) and three dimensions (3D) to form complex structures by combining various types of materials. Magnetic manipulation holds great promise for several applications such as self-assembly of soft substances and biological building blocks, manipulated tissue engineering, as well as cell or biological molecule sorting for diagnostic purposes. Recent studies are proving the potential of magnetic levitation as an emerging tool in biotechnology. This review outlines the advances of newly developing magnetic levitation technology on biological applications in aqueous environment from the biotechnology perspective.
  • Article
    Citation - WoS: 75
    Citation - Scopus: 74
    Scaffold-Free Three-Dimensional Cell Culturing Using Magnetic Levitation
    (Royal Society of Chemistry, 2018) Türker, Esra; Türker, Esra; Demirçak, Nida; Arslan Yıldız, Ahu; Arslan Yıldız, Ahu; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    Three-dimensional (3D) cell culture has emerged as a pioneering methodology and is increasingly utilized for tissue engineering, 3D bioprinting, cancer model studies and drug development studies. The 3D cell culture methodology provides artificial and functional cellular constructs serving as a modular playground prior to animal model studies, which saves substantial efforts, time and experimental costs. The major drawback of current 3D cell culture methods is their dependency on biocompatible scaffolds, which often require tedious syntheses and fabrication steps. Herein, we report an easy-to-use methodology for the formation of scaffold-free 3D cell culture and cellular assembly via magnetic levitation in the presence of paramagnetic agents. To paramagnetize the cell culture environment, three different Gadolinium(iii) chelates were utilized, which led to levitation and assembly of cells at a certain levitation height. The assembly and close interaction of cells at the levitation height where the magnetic force was equilibrated with gravitational force triggered the formation of complex 3D cellular structures. It was shown that Gd(iii) chelates provided an optimal levitation that induced intercellular interactions in scaffold-free format without compromising cell viability. NIH 3T3 mouse fibroblasts and HCC827 non-small-cell lung cancer cells were evaluated via the magnetic levitation system, and the formation of 3D cell culture models was validated for both cell lines. Hereby, the developed magnetic levitation system holds promises for complex cellular assemblies and 3D cell culture studies.
  • Conference Object
    Üç Boyutlu Hücre Kültürü için Polimer Esaslı Ekstrasellüler Matriks Mimetiği
    (Institute of Electrical and Electronics Engineers Inc., 2017) Türker, Esra; Yıldız, Ümit Hakan; Yıldız, Ümit Hakan; Türker, Esra; Arslan Yıldız, Ahu; 04.01. Department of Chemistry; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 04. Faculty of Science
    Elektro-eğirme metodu gelişmiş üretim teknolojilerindendir ve biyomedikal uygulamalarında yaygın olarak kullanılmaktadır. Özellikle doku mühendisliğinde amaç, çalışılacak doku üzerine doğal veya sentetik destek materyali (iskele) üreterek hücrenin uyum sağlayabileceği bir ortam oluşturmaktır. Bu projenin amacı üç boyutlu (3D) hücre kültürü çalışmaları için elektro-eğirme-metodu ile poli(L-laktik-co-epsilon-kaprolakton) (PLLCL) kullanılarak iskele üretilmesidir. Homojen lifler ve uygun gözenek boyutu elde etmek amacıyla optimizasyon çalışmaları yapılmıştır. Elde edilen liflerin çapı, akış hızı ve voltajın artmasıyla azalmaktadır. Taramalı uç elektron mikroskop incelemeleri (SEM) lif morfolojik yapılarının doku iskelesi fabrikasyonu için ideale yakın olduğunu ortaya çıkarmıştır.
  • Master Thesis
    Polymer Based Extracellular Matrix Mimetics for 3d Cell Culture
    (Izmir Institute of Technology, 2018) Türker, Esra; Türker, Esra; Arslan Yıldız, Ahu; Arslan Yıldız, Ahu; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    Tissue engineering combines engineering principles and knowledge of life sciences to improve biological substituents. Three dimensional (3D) supporting structures, namely scaffolds obtained from biomaterials to mimic extracellular matrix (ECM) that provides suitable microenvironment for cell proliferation, migration and differentiation. In this study, poly (L-lactide-co-ε-caprolactone) (PLLCL) and collagen type I was used to fabricate scaffold by electrospinning method. In literature, collagen was often dissolved in toxic and harmful solvents that creates the major problem for cell culture applications. To overcome this problem “co-spinning” methodology is utilized for the formation of non-toxic collagen-based ECM mimetic scaffold. Collagen mixed with water-soluble carrier materials which is either polyvinylpyrrolidone (PVP) or polyvinyl alcohol (PVA) and co-electrospinning is carried out with PLLCL. Fabricated scaffolds were immersed into water to remove co-spinning agent; PVA or PVP, so only PLLCL/Collagen remained. PLLCL has homogeneous fibers in a diameter of 1.312 ± 0.22μm. The contact angle of PLLCL (136.6° ± 2.6) proved hydrophobic behavior of PLLCL material. The contact angle of the scaffold decreased up to 86.7° ± 0.1 confirming that hydrophobic behavior is decreased with the addition of collagen. Also, collagen-containing scaffolds were saturated at lower amount of protein than PLLCL, PLLCL/PVA and PLLCL/PVP scaffolds. Cytotoxicity analysis of scaffolds showed that PVA containing scaffolds had lower viability than PVP containing scaffolds; so most of the cell studies were carried out with PLLCL/ Collagen scaffolds fabricated by PVP cospinning. Cell proliferation on PLLCL/Collagen scaffolds found to be more favorable than PLLCL and PLLCL/PVP scaffolds.