6-Bicycloaryl Substituted (s)- and (r)-5,6 Asymmetric Synthesis, and Anti-Proliferative Properties
| dc.contributor.author | Kasaplar, Pınar | |
| dc.contributor.author | Yılmazer, Özgür | |
| dc.contributor.author | Çağır, Ali | |
| dc.coverage.doi | 10.1016/j.bmc.2008.10.069 | |
| dc.date.accessioned | 2017-04-03T11:55:04Z | |
| dc.date.available | 2017-04-03T11:55:04Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | (R)-Goniothalamin, is a member of styryl lactones, possesses selective cytotoxicity against cancer cell lines. In this work, replacement of styryl substituent with 2-naphthyl and 3-quinoyl gave new analogues which may have less conformational changes compared to the lead compound. Anti-proliferative tests indicated that 2-naphthyl substituted (R)-5,6-dihydro-2H-pyran-2-one has slightly better cytotoxicity than (R)-goniothalamin. To clarify the effect of 2-naphthyl substituent additional aryl substituted (R)-5,6-dihydro-2H-pyran-2-ones have been synthesized enantioselectively and tested against PC-3 and MCF-7 cell lines. | en_US |
| dc.description.sponsorship | TUBITAK (105T429) | en_US |
| dc.identifier.citation | Kasaplar, P., Yılmazer, Ö. and Çağır, A.(2009). 6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative properties. Bioorganic and Medicinal Chemistry, 17(1), 311-318. doi:10.1016/j.bmc.2008.10.069 | en_US |
| dc.identifier.doi | 10.1016/j.bmc.2008.10.069 | en_US |
| dc.identifier.doi | 10.1016/j.bmc.2008.10.069 | |
| dc.identifier.issn | 0968-0896 | |
| dc.identifier.issn | 0968-0896 | |
| dc.identifier.scopus | 2-s2.0-57649200458 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.bmc.2008.10.069 | |
| dc.identifier.uri | https://hdl.handle.net/11147/5204 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd. | en_US |
| dc.relation.ispartof | Bioorganic and Medicinal Chemistry | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | (R)-Goniothalamin | en_US |
| dc.subject | Cancer cell lines | en_US |
| dc.subject | Conformationally constrained analogues | en_US |
| dc.subject | Cytotoxic activity | en_US |
| dc.title | 6-Bicycloaryl Substituted (s)- and (r)-5,6 Asymmetric Synthesis, and Anti-Proliferative Properties | en_US |
| dc.type | Article | en_US |
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| gdc.author.institutional | Kasaplar, Pınar | |
| gdc.author.institutional | Yılmazer, Özgür | |
| gdc.author.institutional | Çağır, Ali | |
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| gdc.description.department | İzmir Institute of Technology. Chemistry | en_US |
| gdc.description.endpage | 318 | en_US |
| gdc.description.issue | 1 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.startpage | 311 | en_US |
| gdc.description.volume | 17 | en_US |
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| gdc.identifier.pmid | 19022676 | |
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| gdc.oaire.keywords | Cytotoxic activity | |
| gdc.oaire.keywords | Cancer cell lines | |
| gdc.oaire.keywords | Antineoplastic Agents | |
| gdc.oaire.keywords | Ketones | |
| gdc.oaire.keywords | Structure-Activity Relationship | |
| gdc.oaire.keywords | (R)-Goniothalamin | |
| gdc.oaire.keywords | Pyrones | |
| gdc.oaire.keywords | Cell Line, Tumor | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Conformationally constrained analogues | |
| gdc.oaire.keywords | Cell Proliferation | |
| gdc.oaire.keywords | Pyrans | |
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