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Duman, Seda
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01.01. Units Affiliated to the Rectorate
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Scholarly Output
6
Articles
4
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9001/1872
Supervised MSc Theses
1
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0
WoS Citation Count
59
Scopus Citation Count
63
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0
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0
WoS Citations per Publication
9.83
Scopus Citations per Publication
10.50
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4
Supervised Theses
1
| Journal | Count |
|---|---|
| Bioorganic Chemistry | 1 |
| Phytochemistry | 1 |
| Phytochemistry Letters | 1 |
| Planta Medica | 1 |
| Turkish Journal of Botany | 1 |
Current Page: 1 / 1
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6 results
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Now showing 1 - 6 of 6
Article Citation - WoS: 27Citation - Scopus: 30Biotransformation of Cyclocanthogenol by the Endophytic Fungus Alternaria Eureka 1e1bl1(Elsevier Ltd., 2018) Ekiz, Güner; Duman, Seda; Duman, Seda; Bedir, Erdal; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of EngineeringThe microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus angustifolius was investigated. Hydroxylation, oxidation, epoxidation, O-methylation, ring-expansion and methyl migration reactions were observed on the triterpenoid skeleton. As a result, eight metabolites were isolated and the structures of the previously undescribed compounds were established by 1-D, 2-D NMR and HR-MS analyses.Master Thesis Fungal Biotransformation of Novel 20(27)- Octanor Cycloastragenol and Biological Activities of the Purified Metabolites(Izmir Institute of Technology, 2019) Duman, Seda; Duman, Seda; Bedir, Erdal; Çağır, Ali; Bedir, Erdal; Çağır, Ali; 03.01. Department of Bioengineering; 04.01. Department of Chemistry; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 04. Faculty of ScienceBiotransformation is the chemical modifications performed by enzymes or living organisms. The difficulty and high cost of enzyme isolation and purification makes it more advantageous to use whole cell systems as biocatalysts. Microbial biocatalysts are particularly interesting in the modification of complex molecules such as steroids and triterpenoids, which can catalyze stereo- and regio- selective reactions that are difficult or impossible to perform with chemical reactions. Specially, ability of endophytic microorganisms to produce specific enzymes for adaptation to their environment by tolerating toxic defense metabolites, makes them interesting for biotransformation studies. Telomeres are nucleotide structures located at the end of chromatids shortening with each cell division. Telomerase is a reverse transcriptase enzyme, and it helps to replenish telomere ends that are truncated by aging and stress factors. The telomerase activators (TA) with their potentials are suggested encouraging agents for healthy aging, and they are projected to generate a huge market in the future. Cycloastragenol is the only natural product in the sector marketed as a potent telomerase activator. In this study, by using endophytic fungi, the biotransformation studies were performed on 20(27)-octanor cycloastragenol. As a result, 14 biotransformation products, were isolated by chromatographic studies, and the structures of the metabolites were established by spectral methods. Based on the literature survey, 13 compounds turned out to be new for nature. Seven metabolites were screened for telomerase activation. In these screenings, metabolites showed telomerase activation ranging from 5.43 to 12.36 fold at doses ranging from 0.1 to 30 nM compared to the control cells treated with DMSO.Article Citation - WoS: 5Citation - Scopus: 5Screening of Cytotoxicity and Dna Topoisomerase Iia Inhibitory Activity of Turkish Onosma Species(TÜBİTAK, 2021) Yılmaz, Sinem; Bedir, Erdal; Duman, Seda; Karakoyun, Çiğdem; Kul, Demet; Pirhan, Ademi Fahri; Bedir, Erdal; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of EngineeringOnosma L., the largest genus of Boraginaceae, is represented by 105 species in Turkey with an endemism rate of 52%. Phytochemical studies indicate that Boraginaceae plants mainly comprise naphthoquinones with a wide range of biological activities including anticancer, antiinflammatory, wound healing, and antioxidant effects. However, few taxa of the genus Onosma have been investigated in detail for their bioactivities. Considering the high rate of endemism and an inadequate number of bioactivity screening studies in literature, we aimed to evaluate the cytotoxic effects and topoisomerase inhibitory activities of some Onosma species growing in southwestern Turkey. Here, we describe a comprehensive cytotoxic activity screening study on petroleum ether, dichloromethane, and methanol extracts of the roots of 20 identified and one unidentified Onosma taxa. The MTT cell viability assay has been performed to investigate the cytotoxicity of the extracts against seven cancer cell lines (MCF-7, HeLa > Hep G2, A549, Capan-1, HCC-1937, and DU-145) and a noncancerous cell line (MRC-5), while doxorubicin was served as a positive standard. The petroleum ether extracts of O. aksoyii Aytac&Turkmen, O. isaurica Boiss. and Heldr., O. taurica Pallas ex Willd. var. taurica and O. alborosea Fisch. & C.A. Mey subsp. alborosea var. alborosea were determined as the most active ones based on their IC50 values. DNA topoisomerase Ila inhibition assay was conducted on the petroleum ether and dichloromethane extracts of these four active species, and almost all tested extracts demonstrated strong inhibition on the enzyme at a concentration of 0.1 mg/mL. Our cytotoxicity screening results were consistent with the findings of the topoisomerase Ila inhibition test. This study advocates the significant role of Onosma species in the field of anticancer drug discovery.Article Citation - WoS: 19Citation - Scopus: 21Telomerase Activators From 20(27)-Octanor Via Biotransformation by the Fungal Endophytes(Academic Press, 2021) Duman, Seda; Bedir, Erdal; Yılmaz, Sinem; Yusufoğlu, Hasan; Ballar Kırmızıbayrak, Petek; Bedir, Erdal; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of EngineeringCycloastragenol [20(R),24(S)-epoxy-3 beta,6 alpha,16 beta,25-tetrahydroxycycloartane] (CA), the principle sapogenol of many cycloartane-type glycosides found in Astragalus genus, is currently the only natural product in the anti-aging market as telomerase activator. Here, we report biotransformation of 20(27)-octanor-cycloastragenol (1), a thermal degradation product of CA, using Astragalus species originated endophytic fungi, viz. Penicillium roseopurpureum, Alternaria eureka, Neosartorya hiratsukae and Camarosporium laburnicola. Fifteen new biotransformation products (2-16) were isolated, and their structures were established by NMR and HRESIMS. Endophytic fungi were found to be capable of performing hydroxylation, oxidation, ring cleavage-methyl migration, dehydrogenation and Baeyer-Villiger type oxidation reactions on the starting compound (1), which would be difficult to achieve by conventional synthetic methods. In addition, the ability of the metabolites to increase telomerase activation in Hekn cells was evaluated, which showed from 1.08 to 12.4-fold activation compared to the control cells treated with DMSO. Among the compounds tested, 10, 11 and 12 were found to be the most potent in terms of telomerase activation with 12.40-, 7.89- and 5.43-fold increase, respectively (at 0.1, 2 and 10 nM concentrations, respectively).Article Citation - WoS: 7Citation - Scopus: 7Flavonol Glycosides From Reseda Lutea L(Elsevier Ltd., 2019) Kızıltaş, Hatice; Bedir, Erdal; Küçüksolak, Melis; Küçüksolak, Melis; Duman, Seda; Duman, Seda; Bedir, Erdal; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of EngineeringTwo new flavonol glycosides; kaempferol-3-O-[2-O-(beta-D-xylopyranosyl)-3-O-(beta-D-glucopyranosyl)]-alpha-L-rhamnopyranosyl-7-O-alpha-L-rhamnopyranoside (1) and kaempferol-3-O-[2-O-((6-O-trans-p-coumaryl)-beta-D-glucopyranosyl)-3-O-(beta-D-xylopyranosyl)]-alpha-L-rhamnopyranosyl-7-O-alpha-L-rhamnopyranoside (2) were isolated from the aerial parts of Reseda lutea L., together with five known flavonol glycosides. Structural elucidation of the compounds was based on both spectroscopic evidence and reference data comparison. The new compounds are the first tetrasaccharidic secondary metabolites isolated from Resedaceae family.Conference Object Citation - WoS: 1Telomerase Activators Derived From Astragalus Sapogenins Via Biotransformation With the Recently Discovered Endophytic Fungus Camarosporium Laburnicola(Georg Thieme Verlag, 2019) Küçüksolak, Melis; Yılmaz, Sinem; Ekiz, Güner; Duman, Seda; Duman, Seda; Bedir, Erdal; Yılmaz, Sinem; Küçüksolak, Melis; Ballar Kırmızıbayrak, Petek; Bedir, Erdal; 03.01. Department of Bioengineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of EngineeringTelomeres are nucleotide sequences that are located at the end of chromosomes shortening with each cell division. Telomerase is a reverse transcriptase enzyme, and it helps to replenish telomere ends that are truncated by aging and stress factors.